Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies [0.03%]
干粉吸入剂设计与颗粒技术在改善肺部药物沉降中的作用：挑战和未来策略
Nazrul Islam,Tan Suwandecha,Teerapol Srichana
Nazrul Islam
Objectives: The efficient delivery of drugs from dry powder inhaler (DPI) formulations is associated with the complex interaction between the device design, drug formulations, and patient's inspiratory forces. Several cha...
Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report [0.03%]
治疗缺铁性贫血对慢性难治性咳嗽的影响——罕见病例报告
Fatemeh Akbari,Lale Vahedi Larijani,Ehsan Rajabi Visroodi et al.
Fatemeh Akbari et al.
Background: A persistent difficult-to-treat cough can be exhausting. Iron is an essential element that plays an important role in regulating the production of pro-inflammatory cytokines, and its deficiency may potentiate ...
Prediction of naloxone dose in opioids toxicity based on machine learning techniques (artificial intelligence) [0.03%]
基于机器学习技术（人工智能）预测阿片类药物中毒的纳洛酮剂量
Seyed Ali Mohtarami,Babak Mostafazadeh,Shahin Shadnia et al.
Seyed Ali Mohtarami et al.
Background: Treatment management for opioid poisoning is critical and, at the same time, requires specialized knowledge and skills. This study was designed to develop and evaluate machine learning algorithms for predictin...
Comparative evaluation of different oral iron salts in the management of iron deficiency anemia [0.03%]
不同口服铁剂在缺铁性贫血管理中疗效的比较评估
Manoj A Suva,Pravin R Tirgar
Manoj A Suva
Background: Anemia affects one-fourth of the world's population and is caused mostly by iron deficiency. Iron supplementation is the most essential strategy for preventing iron deficiency anemia. Conventional oral iron sa...
Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles [0.03%]
壳聚糖微粒包封油橄榄素靶向三维培养模型中的耐药性乳腺癌干细胞
Ozlem Altundag-Erdogan,Rumeysa Tutar,Elif Yüce et al.
Ozlem Altundag-Erdogan et al.
Background: Cancer stem cells (CSCs) are a subpopulation of cancer cells that are believed to be responsible for tumor initiation, progression, metastasis, and resistance to conventional therapies. Oleuropein as a natural...
Royal jelly and its hormonal effects in breast cancer: a literature review [0.03%]
royal jelly及其在乳腺癌中的激素作用：文献综述
Farzaneh Aavani,Roja Rahimi,Pouya Goleij et al.
Farzaneh Aavani et al.
Background: Breast cancer is the most common cancer in women which can be cured in most individuals with early-stage non-metastatic disease. Imbalance in estrogen signaling pathways and propagating levels of estrogens has...
Evaluation of 1,10-phenanthroline-based hydroxamate derivative as dual histone deacetylases/ribonucleotide reductase inhibitor with antitumor activities [0.03%]
基于邻菲啰啉羟胺衍生物作为组蛋白去乙酰酶/核糖核苷酸还原酶双抑制剂的抗肿瘤活性评价研究
Manasa Gangadhar Shetty,Padmini Pai,Bipasa Dey et al.
Manasa Gangadhar Shetty et al.
Background: Aberrant expression of histone deacetylases (HDACs) and ribonucleotide reductase (RR) enzymes are commonly observed in various cancers. Researchers are focusing on these enzymes in cancer studies with the aim ...
Evaluation of time-to-onset and outcome of cardiac adverse events related to pembrolizumab using post-marketing surveillance in Japanese patients [0.03%]
利妥昔替尼相关心脏不良事件的时距及结果：基于日本患者上市后监测数据的评价
Yuko Kanbayashi,Eren Tsuchiya,Tadashi Shimizu et al.
Yuko Kanbayashi et al.
Background: Pembrolizumab has been widely used in patients since its release, but information on cardiac Adverse Events (AEs) related to pembrolizumab remains lacking, particularly in Japanese populations. ...
Zaruhi Kalikyan,Armine Hakobyan
Zaruhi Kalikyan
Drug hypersensitivity reactions (DHRs) manifested as vasculitis are rare. Antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), sulphonamides, diuretics, immunosupressants and anticonvulsants are the most common culprits for drug-ind...
Deciphering the similarities and disparities of molecular mechanisms behind respiratory epithelium response to HCoV-229E and SARS-CoV-2 and drug repurposing, a systems biology approach [0.03%]
基于系统生物学的方法解读人类冠状病毒229E和SARS-CoV-2感染下呼吸道上皮细胞应答机制的异同及老药新用研究
Zeinab Dehghan,Seyed Amir Mirmotalebisohi,Maryam Mozafar et al.
Zeinab Dehghan et al.
Purpose: Identifying the molecular mechanisms behind SARS-CoV-2 disparities and similarities will help find new treatments. The present study determines networks' shared and non-shared (specific) crucial elements in respo...