Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish [0.03%]
对乙酰氨基酚、 metamizol和尼美舒利混合物对斑马鱼早期发育的毒性效应
Wellington Fernandes de Carvalho,Ednalva de Souza Pereira Lima,Whocely Victor de Castro et al.
Wellington Fernandes de Carvalho et al.
Background: Several countries' most incorrectly discarded medicines are acetaminophen (ACM), metamizole (MTZ), and nimesulide (NMS). These xenobiotics easily reach the aquatic environment; such contamination is very impor...
Preparation of poly(vinyl alcohol) nanofibers containing disulfiram-copper complex by electrospinning: a potential delivery system against melanoma [0.03%]
电纺聚乙烯醇纳米纤维中含二硫仑-铜复合物的制备及其作为黑色素瘤防治递送系统的潜力研究
Gomaa F El Fawal,Marwa M Abu-Serie
Gomaa F El Fawal
Background: Melanoma poses a significant threat to human health, making the development of a safe and effective treatment a crucial challenge. Disulfiram (DS) is a proven anticancer drug that has shown effectiveness when ...
Evaluating the effect of sodium alginate and sodium carboxymethylcellulose on pulmonary delivery of levofloxacin spray-dried microparticles [0.03%]
评价藻酸钠和羧甲基纤维素钠对左氧氟沙星喷雾干燥微粒肺部递送的影响
Hanieh Alizadeh,Peyman Khoshhal,Maryam Sadat Mirmoeini et al.
Hanieh Alizadeh et al.
Background: Patients with cystic fibrosis commonly suffer from lung infections caused by Pseudomonas aeruginosa. Recently, the Levofloxacin (LVF) nebulizing solution (Quinsair®) has been prescribed for the antimicrobial ...
Structure-activity relationship of pharmacophores and toxicophores: the need for clinical strategy [0.03%]
药效团单元和毒性单元的结构活性关系及临床策略的需求
Saganuwan Alhaji Saganuwan
Saganuwan Alhaji Saganuwan
Objectives: Sometimes clinical efficacy and potential risk of therapeutic and toxic agents are difficult to predict over a long period of time. Hence there is need for literature search with a view to assessing cause of t...
Repurposing metformin as a potential anticancer agent using in silico technique [0.03%]
利用计算机模拟技术重新定位二甲双胍作为潜在的抗癌药物
Mona Mahfauz,Ozel Yuruker,Rasime Kalkan
Mona Mahfauz
Background: The focus on repurposing readily available, well-known drugs for new, creative uses has grown recently. One such medication is metformin, a drug commonly used to manage diabetes, which shows a favorable correl...
Public interest in drug-related problems reflected in information search trends: an infodemiological study [0.03%]
有关药物问题的公众利益反映在信息搜索趋势中：一项信息流行病学研究
Laura Martínez-Aguilar,María Sanz-Lorente,Fernando Martínez-Martínez et al.
Laura Martínez-Aguilar et al.
Background: The analysis of how people search and "navigate" the internet to obtain health-related information and how they communicate and share this information can provide valuable knowledge about the disease patterns ...
Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin [0.03%]
探究喂食果糖的雌雄大鼠肠道组织中炎症与菌群的关系：二甲双胍的调节作用
Azimet Yalçın Buğdaycı,Saadet Özen Akarca Dizakar,Mürşide Ayşe Demirel et al.
Azimet Yalçın Buğdaycı et al.
Background: It has been reported that High-Fructose (HF) consumption, considered one of the etiological factors of Metabolic Syndrome (MetS), causes changes in the gut microbiota and metabolic disorders. There is limited ...
Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies [0.03%]
干粉吸入剂设计与颗粒技术在改善肺部药物沉降中的作用：挑战和未来策略
Nazrul Islam,Tan Suwandecha,Teerapol Srichana
Nazrul Islam
Objectives: The efficient delivery of drugs from dry powder inhaler (DPI) formulations is associated with the complex interaction between the device design, drug formulations, and patient's inspiratory forces. Several cha...
Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report [0.03%]
治疗缺铁性贫血对慢性难治性咳嗽的影响——罕见病例报告
Fatemeh Akbari,Lale Vahedi Larijani,Ehsan Rajabi Visroodi et al.
Fatemeh Akbari et al.
Background: A persistent difficult-to-treat cough can be exhausting. Iron is an essential element that plays an important role in regulating the production of pro-inflammatory cytokines, and its deficiency may potentiate ...
Prediction of naloxone dose in opioids toxicity based on machine learning techniques (artificial intelligence) [0.03%]
基于机器学习技术（人工智能）预测阿片类药物中毒的纳洛酮剂量
Seyed Ali Mohtarami,Babak Mostafazadeh,Shahin Shadnia et al.
Seyed Ali Mohtarami et al.
Background: Treatment management for opioid poisoning is critical and, at the same time, requires specialized knowledge and skills. This study was designed to develop and evaluate machine learning algorithms for predictin...