Novel 3,3'-diindolylmethane derivatives as multi-pathway modulators: targeting estrogen-dependent and independent breast cancer carcinogenesis [0.03%]
新型3,3'-二吲哚甲烷衍生物作为多通路调节剂：靶向雌激素依赖性和非依赖性乳腺癌发生发展
Elif Ince-Erguc,Bita Entezari,Hanif Sirinzade et al.
Elif Ince-Erguc et al.
Purpose: Breast cancer remains a leading cause of cancer-related mortality among women, with prolonged exposure to endogenous estrogens recognized as a major risk factor. This study aimed to design, synthesize, and pharma...
Solid nano-lipoidal intelligent premix (SNIP): designing, optimization, and characterization [0.03%]
固体纳米脂质智能预混剂（SNIP）的设计、优化和特征分析
Hardik Rana,Noopur Patel,Vaishali Thakkar et al.
Hardik Rana et al.
Background: Bicalutamide possesses very low oral bioavailability due to its low water solubility and p-gp efflux. The present invention aimed to improve the solubility and availability of Bicalutamide at the absorption si...
Biosynthesis, characterization, and antiproliferative activity of gold nanoparticles synthesized using Artemisia chamaemelifolia extract against cisplatin-resistant ovarian cancer cells [0.03%]
牻牛儿苗提取物合成的金纳米颗粒的生物合成，表征及其对顺铂耐药卵巢癌细胞的抗增殖活性
Ali Shirafkan,Mohammad Sadegh Hashemzadeh,Mozafar Mohammadi
Ali Shirafkan
Background: Ovarian cancer remains a major clinical challenge, largely because many patients eventually develop resistance to cisplatin. In this study, gold nanoparticles (AuNPs) were synthesized using Artemisia chamaemel...
Cost-Effectiveness of olaparib plus bevacizumab versus bevacizumab monotherapy as first-line maintenance for patients with advanced ovarian cancer: a analysis from a Chinese healthcare perspective [0.03%]
奥拉帕利联合贝伐单抗对比贝伐单抗维持治疗晚期卵巢癌的 cost-effectiveness分析：中国人群的经济学分析视角
Pengxiang Cai,Jin Liu,Caifen Yu et al.
Pengxiang Cai et al.
Objective: The PAOLA-1 trial demonstrated that olaparib plus bevacizumab (OB) significantly prolonged progression-free survival (PFS) and overall survival (OS) compared to bevacizumab monotherapy (BM) as first-line mainte...
Deep fused explainable neural architecture for the automatic recognition of therapeutic medicinal plants [0.03%]
深度融合可解释神经架构在药用植物自动识别中的应用
Pooja Govindaraj,N Sasikaladevi
Pooja Govindaraj
Background: Medicinal plants have been utilized for centuries for their beneficial properties and significant impact on traditional medical systems worldwide. Indian medicinal plants and their therapeutic properties have ...
Poly (lactic-co-glycolic acid) nanoplatforms for triple-negative breast cancer: current progress, advances, and future outlook [0.03%]
用于三阴性乳腺癌的聚乳酸-丙交酯纳米平台：目前的研究进展、展望及未来前景
Aakash Sharma,Ashwini Kumar Mishra,Pooja Mathur et al.
Aakash Sharma et al.
Triple-negative breast cancer (TNBC) is a highly aggressive subtype with the poorest prognosis and the highest recurrence rates. PLGA nanoplatforms show great potential as delivery systems for treating aggressive TNBC. A wide variety of nan...
Circadian-guided asthma therapy: compressed-coated chronotherapeutic tablets for precision early-morning drug delivery [0.03%]
基于昼夜节律的哮喘疗法：压缩包衣的按时间治疗片剂实现精确的清晨用药
Kumari Sindhu,Parveen Kumar,Amit Kumar et al.
Kumari Sindhu et al.
Background: Early-morning worsening of asthma, most often observed between 03:00 and 06:00 am, arises from circadian regulation of airway smooth muscle tone, enhanced nocturnal release of inflammatory mediators, and the p...
Therapeutic targeting of COX-2 in head and neck cancer: Mechanistic and clinical perspectives [0.03%]
从机制和临床角度探讨环氧化酶-2在头颈部肿瘤治疗中的作用
Reena Gupta,Bilal Khaleel Midhin,Sabir Ali Siddiqui et al.
Reena Gupta et al.
Cyclooxygenase-2 (COX-2) is a key player in inflammation; it is often over-activated in HNSCC, which consequently increases the levels of prostaglandin E2 (PGE2) (an inflammatory mediator) leading to tumor proliferation, angiogenesis, epith...
Chitosan-carboxymethyl tara gum polyelectrolyte complex matrix tablets for sustained gastrointestinal drug dissolution using paracetamol as a model drug [0.03%]
基于氯化胆碱改性刺槐豆胶的壳聚糖/刺槐豆胶多电解质复合作为控制药物释放载体的研究（以扑热息痛为例）
Md Sahil Shanawaz Alam,Tapan Kumar Giri,Kaushik Mukherjee
Md Sahil Shanawaz Alam
Background: Natural polysaccharides are extensively used for delivery of bioactives because of its eco-friendly, biocompatible and biodegradable characteristics. However, substantial swelling and poor rheological characte...
Wistar rat model experiments for increasing intraocular pressure: a systematic review [0.03%]
用于增加眼内压的威斯特大鼠模型实验：系统评价研究
Anush Nayak,Deveswaran R,Swati Sinha et al.
Anush Nayak et al.
Background: Glaucoma is a leading cause of irreversible vision loss, with elevated intraocular pressure (IOP) being the primary modifiable risk factor. Experimental models that reliably induce ocular hypertension (OHT) ar...