Network analysis-guided drug repurposing: IGF1R as a novel melanoma target and therapeutic potential of dapagliflozin [0.03%]
Fatemeh Hajipour,Melika Alesheikh,Maliheh Safavi et al.
Fatemeh Hajipour et al.
Background: Skin Cutaneous Melanoma (SKCM) is an aggressive malignancy requiring novel therapeutic targets. Objectives: This study aime...
Amorphous solid dispersions as a strategy to enhance the bioavailability and stability of formulations containing plant active ingredients: An integrative review [0.03%]
无定形固态分散技术增强植物药用成分药物制剂溶解度和稳定性的整合评价综述
Maria Eduarda de Oliveira Cardoso Melo,Camila Castro da Silva,Thainá Dos Santos Dantas et al.
Maria Eduarda de Oliveira Cardoso Melo et al.
Objectives: Plant-derived active pharmaceutical ingredients (APIs), including crude extracts, phytocomplexes, and isolated compounds, have been extensively investigated due to their therapeutic potential. However, their p...
Assessment of potential drug interactions in rheumatology: a comparative study of decision support software [0.03%]
风湿病药物相互作用评估：决策支持软件的比较研究
Yeliz Şahin,Huri Beyza Yildirim,Helin Okumuş et al.
Yeliz Şahin et al.
Background: Rheumatologic diseases often require long-term, complex pharmacotherapy involving immunosuppressive and anti-inflammatory agents. This complexity leads to a high prevalence of polypharmacy and increases the ri...
Proposed echocardiography-guided flowchart for calcium channel blocker overdose: distinguishing vasoplegia from cardiogenic shock [0.03%]
基于床旁超声心动图的钙离子拮抗剂中毒流程分析：血管麻痹与心源性休克的区别
Omid Mehrpour,Jeffrey Brent
Omid Mehrpour
Background: Calcium channel blocker (CCB) overdose can present as vasoplegic or cardiogenic shock, but current guidance does not operationalize bedside echocardiography to direct therapy. ...
Exploring the efficacy of a novel cannabidiol and bevacizumab combination in non-small cell lung cancer [0.03%]
探究大麻二酚与贝伐单抗联合治疗非小细胞肺癌的疗效研究
Abdul Qadir,Zurqa Khalid,Ayesha Kashmala Ghauri et al.
Abdul Qadir et al.
Background: Lung cancer remains the leading cause of cancer-related mortality worldwide. Despite advances in therapeutic strategies, the 5-year survival rate for patients with non-small cell lung cancer (NSCLC) remains ap...
Exploring the potential of cinnamic acid analogues in alzheimer's disease [0.03%]
肉桂酸类似物在阿尔茨海默病中的潜在作用研究
Padmaja Patil,Shreyash Jaiswal,Arati Prabhu
Padmaja Patil
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Oxidative stress, exacerbated by mitoc...
Unveiling the therapeutic potential of Farnesol against Parkinson's disease: insights from molecular Docking and animal studies [0.03%]
法尼醇治疗帕金森病的潜力：来自分子对接和动物研究的新见解
Hirok Jyoti Baishya,Jyutia Nargish,Piyong Sola
Hirok Jyoti Baishya
Background: Parkinson's disease (PD) is a chronic neurodegenerative disorder that progressively worsens over an individual's lifetime. Current treatments primarily address the symptoms rather than the underlying cause of ...
Clinical, humanistic, and economic outcomes of Passiflora alata Curtis use in participants with mild to moderate anxiety: a non-randomized experimental study [0.03%]
柯里辛香藤治疗轻中度焦虑的临床、人文和经济效益：一项实验性研究
Thatiane Bárbara de Barros,Astrid Wiens,Tiago Marques Dos Reis
Thatiane Bárbara de Barros
Background: Anxiety is a disorder treated through psychotherapy and/or pharmacotherapy. Passiflora alata Curtis is a herbal medicine used as a therapeutic alternative, although clinical evidence supporting its effectivene...
Plant-derived compounds as potential candidates for atrial fibrillation drug discovery: A review on phytochemicals with atrial-selective activity [0.03%]
植物源化合物作为心房颤动药物发现的潜在候选物：具有心房选择性活性的植物化学物质综述
Bayan Azizi,Danesh Soltani,Arian Tavasol et al.
Bayan Azizi et al.
Evaluation of metformin's effect on 5-fluorouracil-induced cardiotoxicity through cellular protection [0.03%]
评估二甲双胍对5-氟尿嘧啶致心肌毒性的细胞保护效应
Nahlah Fahad Alreshidi,Reham Abdullah Al-Dhelaan,Amjad Yousuf et al.
Nahlah Fahad Alreshidi et al.
Background: 5-Fluorouracil (5-FU) is a chemotherapeutic agent used primarily to treat various cancers. While it has been successful in improving cancer survival rates, 5-FU is also known to be cardiotoxic. Treatment optio...