Dispersive micro-solid phase extraction based on two MOFs as highly effective adsorbents for analysis of nilotinib in plasma and wastewater [0.03%]
一种基于两种MOF吸附剂的分散微固相萃取法用于测定血浆和废水中的尼洛替尼
Azra Takhvar,Somaye Akbari,Effat Souri et al.
Azra Takhvar et al.
Background: Nilotinib (NIL) is a prescription medication employed in the treatment of specific types of leukemia, namely chronic myelogenous leukemia (CML). The determination of NIL levels in patients undergoing treatment...
Hybrid derivatives containing dimethyl fumarate and benzothiazole scaffolds for the potential treatment of multiple sclerosis; in silico & in vivo study [0.03%]
含富马酸二甲酯和苯并噻唑支架的杂合衍生物作为潜在多发性硬化症治疗药物的体内及体外研究
Seyedeh Azin Mirmotahari,Mehdi Aliomrani,Farshid Hassanzadeh et al.
Seyedeh Azin Mirmotahari et al.
Background: Multiple Sclerosis (MS) is a chronic autoimmune, inflammatory neurological disease of the CNS. Riluzole and dimethyl fumarate (DMF) are two FDA-approved drugs to treat amyotrophic lateral sclerosis (ALS) and M...
Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication [0.03%]
COVID-19治疗药物的耐药机制及副作用与其根除瓶颈关系的假设机制探讨
Swarnali Das,Sreyashi Nath,Shahjahan et al.
Swarnali Das et al.
Background: COVID-19 pandemic has turned our world upside down by meddling with our normal lives. While there is no definitive drug against SARS-CoV-2, antiviral drugs that are already in the market, are being repurposed ...
Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish [0.03%]
对乙酰氨基酚、 metamizol和尼美舒利混合物对斑马鱼早期发育的毒性效应
Wellington Fernandes de Carvalho,Ednalva de Souza Pereira Lima,Whocely Victor de Castro et al.
Wellington Fernandes de Carvalho et al.
Background: Several countries' most incorrectly discarded medicines are acetaminophen (ACM), metamizole (MTZ), and nimesulide (NMS). These xenobiotics easily reach the aquatic environment; such contamination is very impor...
Preparation of poly(vinyl alcohol) nanofibers containing disulfiram-copper complex by electrospinning: a potential delivery system against melanoma [0.03%]
电纺聚乙烯醇纳米纤维中含二硫仑-铜复合物的制备及其作为黑色素瘤防治递送系统的潜力研究
Gomaa F El Fawal,Marwa M Abu-Serie
Gomaa F El Fawal
Background: Melanoma poses a significant threat to human health, making the development of a safe and effective treatment a crucial challenge. Disulfiram (DS) is a proven anticancer drug that has shown effectiveness when ...
Evaluating the effect of sodium alginate and sodium carboxymethylcellulose on pulmonary delivery of levofloxacin spray-dried microparticles [0.03%]
评价藻酸钠和羧甲基纤维素钠对左氧氟沙星喷雾干燥微粒肺部递送的影响
Hanieh Alizadeh,Peyman Khoshhal,Maryam Sadat Mirmoeini et al.
Hanieh Alizadeh et al.
Background: Patients with cystic fibrosis commonly suffer from lung infections caused by Pseudomonas aeruginosa. Recently, the Levofloxacin (LVF) nebulizing solution (Quinsair®) has been prescribed for the antimicrobial ...
Structure-activity relationship of pharmacophores and toxicophores: the need for clinical strategy [0.03%]
药效团单元和毒性单元的结构活性关系及临床策略的需求
Saganuwan Alhaji Saganuwan
Saganuwan Alhaji Saganuwan
Objectives: Sometimes clinical efficacy and potential risk of therapeutic and toxic agents are difficult to predict over a long period of time. Hence there is need for literature search with a view to assessing cause of t...
Repurposing metformin as a potential anticancer agent using in silico technique [0.03%]
利用计算机模拟技术重新定位二甲双胍作为潜在的抗癌药物
Mona Mahfauz,Ozel Yuruker,Rasime Kalkan
Mona Mahfauz
Background: The focus on repurposing readily available, well-known drugs for new, creative uses has grown recently. One such medication is metformin, a drug commonly used to manage diabetes, which shows a favorable correl...
Public interest in drug-related problems reflected in information search trends: an infodemiological study [0.03%]
有关药物问题的公众利益反映在信息搜索趋势中：一项信息流行病学研究
Laura Martínez-Aguilar,María Sanz-Lorente,Fernando Martínez-Martínez et al.
Laura Martínez-Aguilar et al.
Background: The analysis of how people search and "navigate" the internet to obtain health-related information and how they communicate and share this information can provide valuable knowledge about the disease patterns ...
Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin [0.03%]
探究喂食果糖的雌雄大鼠肠道组织中炎症与菌群的关系：二甲双胍的调节作用
Azimet Yalçın Buğdaycı,Saadet Özen Akarca Dizakar,Mürşide Ayşe Demirel et al.
Azimet Yalçın Buğdaycı et al.
Background: It has been reported that High-Fructose (HF) consumption, considered one of the etiological factors of Metabolic Syndrome (MetS), causes changes in the gut microbiota and metabolic disorders. There is limited ...