Zvanaka Mazhandu,Tebogo Mashifana
Zvanaka Mazhandu
Global water availability has been affected by a variety of factors, including climate change, water pollution, urbanization, and population growth. These issues have been particularly acute in many parts of the world, where access to clean...
Structure based exploration of mitochondrial alpha carbonic anhydrase inhibitors as potential leads for anti-obesity drug development [0.03%]
基于结构的线粒体α碳酸酐酶抑制剂抗肥胖药物研发中的作用及其机制研究
Ipsa Padhy,Tripti Sharma,Biswajit Banerjee et al.
Ipsa Padhy et al.
Background: Obesity has emerged as a major health challenge globally in the last two decades. Dysregulated fatty acid metabolism and de novo lipogenesis are prime causes for obesity development which ultimately trigger ot...
Fatemeh Rahimi,Ali Massoudifar,Roya Rahimi
Fatemeh Rahimi
Objectives: Tobacco smoking is a worldwide health problem and one of the leading causes of premature deaths in last years. As there are lots of researches focusing on cessation strategies with attention to pharmacotherapy...
Lipid management strategies for diabetic patients align with an evidence-based guideline [0.03%]
糖尿病患者的血脂管理策略符合基于证据的指南
Mona Kargar,Noushid Zare,Aarefeh Jafarzadeh Kohneloo et al.
Mona Kargar et al.
Background: Diabetes mellitus (DM) increases the risk of cardiovascular diseases (CVD) significantly. Statins are recommended for all diabetic patients aged ≥ 40 years to alleviate this risk. ...
Glatiramer acetate in situ forming gel, a new approach for multiple sclerosis treatment [0.03%]
一种新的治疗多发性硬化症的方法：原位凝胶成型的醋酸格拉默注射液
Anahita Shobeirean,Hossein Attar,Reyhaneh Varshochian et al.
Anahita Shobeirean et al.
Background: Glatiramer acetate (GA), a commonly used treatment for multiple sclerosis (MS), requires long-term frequent injections to ensure its effectiveness. This often leads to adverse effects, patient noncompliance, a...
A review of the ethnomedicinal, phytochemical, and pharmacological properties of the Ferulago genus based on Structure-Activity Relationship (SAR) of coumarins [0.03%]
基于香豆素的结构活性关系（SAR），对Ferulago属草药、次生代谢产物和药理特性的综述研究
Farid Dabaghian,Shokoufeh Aalinezhad,Alaleh Riazati Kesheh et al.
Farid Dabaghian et al.
Background: The Ferluago W.D.J. Koch genus includes 48 accepted perennial herbs that are distributed in the Mediterranean region, Southeast Europe, Central and Middle East of Asia. These plants are widely used in folk and...
Population Pharmacokinetics of Loxoprofen and its alcoholic metabolites in healthy Korean men [0.03%]
韩国健康男性患者体内柳氮酚和其酒精代谢产物的群体药代动力学分析
Ji-Hun Jang,Ho-Suk Kang,Seung-Hyun Jeong
Ji-Hun Jang
Background: Loxoprofen has been actively used clinically to relieve musculoskeletal pain and inflammatory symptoms. However, there are few reports on quantitative pharmacokinetic (PK) prediction tools and diversity analyz...
Dispersive micro-solid phase extraction based on two MOFs as highly effective adsorbents for analysis of nilotinib in plasma and wastewater [0.03%]
一种基于两种MOF吸附剂的分散微固相萃取法用于测定血浆和废水中的尼洛替尼
Azra Takhvar,Somaye Akbari,Effat Souri et al.
Azra Takhvar et al.
Background: Nilotinib (NIL) is a prescription medication employed in the treatment of specific types of leukemia, namely chronic myelogenous leukemia (CML). The determination of NIL levels in patients undergoing treatment...
Hybrid derivatives containing dimethyl fumarate and benzothiazole scaffolds for the potential treatment of multiple sclerosis; in silico & in vivo study [0.03%]
含富马酸二甲酯和苯并噻唑支架的杂合衍生物作为潜在多发性硬化症治疗药物的体内及体外研究
Seyedeh Azin Mirmotahari,Mehdi Aliomrani,Farshid Hassanzadeh et al.
Seyedeh Azin Mirmotahari et al.
Background: Multiple Sclerosis (MS) is a chronic autoimmune, inflammatory neurological disease of the CNS. Riluzole and dimethyl fumarate (DMF) are two FDA-approved drugs to treat amyotrophic lateral sclerosis (ALS) and M...
Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication [0.03%]
COVID-19治疗药物的耐药机制及副作用与其根除瓶颈关系的假设机制探讨
Swarnali Das,Sreyashi Nath,Shahjahan et al.
Swarnali Das et al.
Background: COVID-19 pandemic has turned our world upside down by meddling with our normal lives. While there is no definitive drug against SARS-CoV-2, antiviral drugs that are already in the market, are being repurposed ...