Pre-emptive hydrocortisone therapy in early septic shock: a double-blind, allocation-concealed, pilot randomized controlled trial [0.03%]
早期脓毒症性休克患者使用氢化可的松治疗的先行研究：双盲随机对照临床试验
Ehsan Emami,Emad Molaei,Samrand Fattah Ghazi et al.
Ehsan Emami et al.
Background: Sepsis, a major global health issue, often progresses to septic shock with high morbidity and mortality. Corticosteroids especially low-dose hydrocortisone have shown promise in septic shock management. Howeve...
Randomized Controlled Trial
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2025 Jul 23;33(2):25. DOI:10.1007/s40199-025-00571-0 2025
Drug repositioning: examining antipsychotic drugs and their anticancer effects [0.03%]
药物再定位：抗精神病药物的抗癌作用分析
Aysen Sagnak,Ferda Ari
Aysen Sagnak
Cancer leads the list of causes of death worldwide, and the search for new and rapid treatment options for this disease has accelerated. New chemotherapeutic agents that inhibit tumor growth and proliferation are being introduced to the mar...
From code to cure: AI-Driven innovation in monoclonal antibody development [0.03%]
从代码到治愈：人工智能驱动的单克隆抗体开发创新
Mohammad Shafiei,Mohammad Ali Faramarzi,Somayeh Mojtabavi
Mohammad Shafiei
Efficacy of dostarlimab in recurrent or advanced mismatch Repair-Deficient endometrial Cancer as a Single-Agent therapy: A systematic review and Meta-Analysis [0.03%]
单一药物治疗错配修复缺陷型子宫内膜癌复发或晚期病例的有效性：一项系统综述和荟萃分析
Ramazan Rezaei,Hedieh Haji Khodaverdi Khani
Ramazan Rezaei
Background: The effectiveness of PD-1 inhibitors for treating endometrial cancer (EC) remains a topic of debate. Guidelines lack consistency regarding the preferred treatments for advanced cases, as well as for patients e...
Glucocorticoid withdrawal syndrome: Disproportionality analysis of cases using VigiBase data [0.03%]
糖皮质激素撤药综合征：基于VigiBase数据的 disproportionality 分析病例
Lütfi Mangal,Burcu Eda Arda,Hande Sipahi
Lütfi Mangal
Background: Glucocorticoids are associated with withdrawal syndrome, but specific glucocorticoid types that cause severe conditions remain unclear. Object...
Behrouz Seyfinejad,Kimiya Jouyban,Jalil Houshyar et al.
Behrouz Seyfinejad et al.
Background: Metoprolol, a widely used β-blocker, is administered as a racemic mixture, with (S)-metoprolol being more pharmacologically active. Its metabolism by CYP2D6 exhibits significant inter-individual variability d...
Cleaning validation in pharmaceutical quality control laboratories: a structured protocol for contamination risk mitigation [0.03%]
制药质量控制实验室的清洁验证：一种有组织的操作规程以降低污染风险
Maria J Moura,André D Pereira,Daniel J F Santos et al.
Maria J Moura et al.
Background: Cleaning activities are critical in pharmaceutical manufacturing to prevent cross-contamination of Active Pharmaceutical Ingredients (APIs). Traditionally, cleaning validation protocols have focused on product...
Synthesis and optimization of fluoxetine-loaded polymeric nanoparticles for dual therapeutic applications in cancer and depression [0.03%]
一种用于癌症和抑郁症的双重治疗的氟西汀载药聚合物纳米颗粒的合成与优化
Muhammad Shoaib,Hira Arif,Asia Naz Awan et al.
Muhammad Shoaib et al.
Background: Fluoxetine, an antidepressant, has shown potential anticancer effects. However, its therapeutic efficacy is limited by its poor bioavailability and rapid metabolism. Nanotechnology is advancing medicine, parti...
The impact of Rosa dmascena Mill. on gastrointestinal disorders: a comprehensive analysis through clinical trials, systematic review, and meta-analysis [0.03%]
Rosa dmascena Mill. 对胃肠疾病的影响：通过临床试验、系统回顾和荟萃分析的全面分析
Nader Behgam,Sobhan Rahimi Esbo,Hossein-Ali Nikbakht et al.
Nader Behgam et al.
Objectives: Rosa damascena Mill. has been studied in clinical trials for the treatment of diverse gastrointestinal diseases. The aim of this study is to conduct a systematic review and meta-analysis of clinical trials usi...
Efficacy and safety of different dosages of rituximab for myasthenia gravis: a single-arm meta-analysis [0.03%]
不同剂量的利妥昔单抗治疗重症肌无力的有效性和安全性：一项单臂荟萃分析
Jianchun Li,Di Chen,Fei Zhao et al.
Jianchun Li et al.
Background: Rituximab (RTX) is one of the treatment options for refractory myasthenia gravis (MG), yet the optimal dosing schedule remains undetermined. Our study aims to explore this issue and offer a valuable reference ...