Co-delivery of SN38 and rapamycin albumin bound nanoparticles against breast Cancer [0.03%]
白蛋白结合型纳米颗粒联合递送SN38和雷帕霉素用于乳腺癌治疗
Sanaz Jamshidfar,Marzieh Ebrahimi,Reyhaneh Varshochian et al.
Sanaz Jamshidfar et al.
Background: The co-delivery of two therapeutic agents within a single nanoparticle platform offers a potential strategy to improve treatment efficacy while minimizing adverse effects. Albumin as a biocompatible carrier co...
Evaluation and comparison of the anti-proliferative and anti-metastatic effects of urolithin A and urolithin B against esophageal cancer cells: an in vitro and in silico study [0.03%]
基于体外和分子对接研究的去氢松香酸抗肝癌活性及其机制探讨
Maryam Shojaee,Mehdi Rostami,Mohammad Soukhtanloo et al.
Maryam Shojaee et al.
Introduction: Esophageal squamous cell carcinoma (ESCC) is a prevalent and lethal cancer, with traditional treatments often ineffective. This study investigates the anti-proliferative and anti-metastatic effects of natura...
The effect of Fe3O4 biosynthesized through the green synthesis of Silybum marianum and HA in the targeted delivery of 5-Fluorouracil to HCT116 cell line [0.03%]
通过乳蓟和HA绿色合成Fe3O4对HCT116细胞系靶向递送5-氟尿嘧啶的影响
Atefeh Mansuryar,Shima Bourang,Mehran Noruzpour et al.
Atefeh Mansuryar et al.
Background and objectives: The administration of 5-FU as the first chemotherapeutic agent for colorectal cancer, showed difficulties including short half-life and the development of resistance. One prominent approach to o...
Pre-emptive hydrocortisone therapy in early septic shock: a double-blind, allocation-concealed, pilot randomized controlled trial [0.03%]
早期脓毒症性休克患者使用氢化可的松治疗的先行研究：双盲随机对照临床试验
Ehsan Emami,Emad Molaei,Samrand Fattah Ghazi et al.
Ehsan Emami et al.
Background: Sepsis, a major global health issue, often progresses to septic shock with high morbidity and mortality. Corticosteroids especially low-dose hydrocortisone have shown promise in septic shock management. Howeve...
Randomized Controlled Trial
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2025 Jul 23;33(2):25. DOI:10.1007/s40199-025-00571-0 2025
Drug repositioning: examining antipsychotic drugs and their anticancer effects [0.03%]
药物再定位：抗精神病药物的抗癌作用分析
Aysen Sagnak,Ferda Ari
Aysen Sagnak
Cancer leads the list of causes of death worldwide, and the search for new and rapid treatment options for this disease has accelerated. New chemotherapeutic agents that inhibit tumor growth and proliferation are being introduced to the mar...
From code to cure: AI-Driven innovation in monoclonal antibody development [0.03%]
从代码到治愈：人工智能驱动的单克隆抗体开发创新
Mohammad Shafiei,Mohammad Ali Faramarzi,Somayeh Mojtabavi
Mohammad Shafiei
Efficacy of dostarlimab in recurrent or advanced mismatch Repair-Deficient endometrial Cancer as a Single-Agent therapy: A systematic review and Meta-Analysis [0.03%]
单一药物治疗错配修复缺陷型子宫内膜癌复发或晚期病例的有效性：一项系统综述和荟萃分析
Ramazan Rezaei,Hedieh Haji Khodaverdi Khani
Ramazan Rezaei
Background: The effectiveness of PD-1 inhibitors for treating endometrial cancer (EC) remains a topic of debate. Guidelines lack consistency regarding the preferred treatments for advanced cases, as well as for patients e...
Glucocorticoid withdrawal syndrome: Disproportionality analysis of cases using VigiBase data [0.03%]
糖皮质激素撤药综合征：基于VigiBase数据的 disproportionality 分析病例
Lütfi Mangal,Burcu Eda Arda,Hande Sipahi
Lütfi Mangal
Background: Glucocorticoids are associated with withdrawal syndrome, but specific glucocorticoid types that cause severe conditions remain unclear. Object...
Behrouz Seyfinejad,Kimiya Jouyban,Jalil Houshyar et al.
Behrouz Seyfinejad et al.
Background: Metoprolol, a widely used β-blocker, is administered as a racemic mixture, with (S)-metoprolol being more pharmacologically active. Its metabolism by CYP2D6 exhibits significant inter-individual variability d...
Cleaning validation in pharmaceutical quality control laboratories: a structured protocol for contamination risk mitigation [0.03%]
制药质量控制实验室的清洁验证：一种有组织的操作规程以降低污染风险
Maria J Moura,André D Pereira,Daniel J F Santos et al.
Maria J Moura et al.
Background: Cleaning activities are critical in pharmaceutical manufacturing to prevent cross-contamination of Active Pharmaceutical Ingredients (APIs). Traditionally, cleaning validation protocols have focused on product...