The effect of physical activity on epileptic seizures and consequentlearning and memory impairment in electrical amygdala kindling model [0.03%]
运动对电惊厥诱导的大鼠海马痫性发作及学习记忆障碍的影响
Abbas Kebriaeezadeh,Reza Zaferi,Mohammad Sharifzadeh et al.
Abbas Kebriaeezadeh et al.
Background: A recent body of evidence has suggested regular exercise as a promising complementary therapeutic strategy in the management of epilepsy and its related cognitive impairments. ...
Falcarindiol induces apoptosis, ROS accumulation, and cell cycle arrest via EGFR/mTOR pathway modulation: an integrated in silico and in vitro study in cervical cancer [0.03%]
法卡令醇通过调节EGFR/mTOR途径诱导宫颈癌细胞凋亡、ROS积累和细胞周期停滞：一种集成的体内体外研究
Ganesh Timalsina,Bishnu Prasad Parida,Megha Radhakrishnan et al.
Ganesh Timalsina et al.
Background: Falcarindiol, a bioactive polyacetylene, has shown cytotoxic effects in several cancers including breast, colorectal, and oral squamous carcinoma, but its pharmacological actions in cervical cancer are not wel...
Unveiling the multitarget anticancer potential of Cochlospermum religiosum: phytochemical profiling, molecular docking, and in vitro/in vivo validation [0.03%]
Cochlospermum religiosum的多靶抗肿瘤潜力：植物化学分析、分子对接及体内外验证
SaiPrasanna Rasamalla,Jayhind Bharti,Priyadharshini Gogu et al.
SaiPrasanna Rasamalla et al.
Background: Cochlospermum religiosum (CR) is a traditionally valued medicinal plant, but its anticancer constituents and mechanisms remain poorly understood. ...
Comparative efficacy of obicetrapib and anacetrapib in reducing low-density lipoprotein (LDL) levels: a network meta-analysis of clinical trials [0.03%]
obicetrapib与anacetrapib降低低密度脂蛋白(LDL)水平疗效的网络Meta分析研究
Abdel Rahman Jaber,Jihad Abu Zayed,Zaid Alabed et al.
Abdel Rahman Jaber et al.
Background: Cholesteryl ester transfer protein (CETP) inhibitors, specifically anacetrapib and obicetrapib, have shown strong lipid-modifying effects by lowering low-density lipoprotein cholesterol (LDL-C) and altering ot...
Development and evaluation of chitosan-xanthan gum-based controlled release nanoparticles of mebeverine hydrochloride for targeted IBS therapy: in silico, in vitro, and in vivo investigations [0.03%]
基于壳聚糖-黄原胶的羟氯曲美布丁缓释纳米颗粒的开发及评价：针对IBS治疗的模拟、体外和体内研究
V V Siva Krishna Pushadapu,Grandhi Srikar
V V Siva Krishna Pushadapu
Background: Irritable bowel syndrome (IBS) requires long-term, site-specific therapy. Mebeverine hydrochloride is effective but limited by rapid metabolism and frequent dosing. This study aimed to develop colon-targeted, ...
Resveratrol and caffeic acid attenuate diet-induced obesity by inhibiting the SREBP-1/ACLY lipogenic axis in adipose tissue of rats [0.03%]
白藜芦醇和咖啡酸通过抑制SREBP-1/ACLY脂生成轴减少大鼠脂肪组织中高脂饮食诱导的肥胖作用
Mohamed M Elseweidy,Dalia G Hagraous,Abdelmoniem A Ali et al.
Mohamed M Elseweidy et al.
Obesity is a health problem with an economic burden. This study examined the anti-obesogenic impact of caffeic acid (Caf) or resveratrol (Res) and their effect on lipogenic enzymes. Wister albino rats received high-fat diet (HFD) for 16 wee...
Harnessing therapeutic potential of bromelain and its nanoformulations: sojourn of pineapple from food to nanomedicine [0.03%]
菠萝蛋白酶及其纳米递送制剂的治疗潜力探索——从食物到药物的旅程
Rajge Rahul Ravindra,Jaskiran Kaur,Sukriti Vishwas et al.
Rajge Rahul Ravindra et al.
Background: Bromelain is a proteolytic enzyme obtained from pineapple stems, possessing diverse pharmacological properties such as antioxidant, antidiabetic, anticancer, anti-inflammatory, anthelmintic, cardioprotective, ...
Synergistic effects of Calebin A and docetaxel on apoptosis and migration in prostate cancer cells [0.03%]
钙叶林A和多西他赛对前列腺癌细胞凋亡和迁移的协同作用
MohammadMostafa Askarnia Faal,Tandiseh Tasbandi,Mahdieh Aliyari et al.
MohammadMostafa Askarnia Faal et al.
Background: Resistance to docetaxel (DTX), a frontline chemotherapeutic agent for prostate cancer (PC), remains a major therapeutic challenge, often driven by impaired apoptosis and enhanced metastatic potential. Calebin ...
Advances in nanostructured drug delivery systems for cardiovascular therapeutics [0.03%]
心血管治疗的纳米结构药物输送系统进展
Mohamed J Saadh,Omer Qutaiba B Allela,Radhwan Abdul Kareem et al.
Mohamed J Saadh et al.
Background: Cardiovascular diseases (CVDs) remain the leading cause of death globally, necessitating innovative therapeutic strategies. Nanoparticles have emerged as a promising tool due to their unique properties, includ...
An expert criticism on post-publication peer review platforms: the case of pubpeer [0.03%]
对发表后同行评审平台的专家批评——以pubpeer为例
Aristidis Tsatsakis,Michael Aschner,Dimosthenis Sarigiannis et al.
Aristidis Tsatsakis et al.
While traditional peer review offers advantages in academic publishing, it is often hampered by significant weaknesses, leading to frustration among many authors. Scientific discoveries after publication depend on thorough discussions and c...