Hyun Mi Kang,Dong Sung Kim,Yong Kyun Kim et al.
Hyun Mi Kang et al.
Recent advancements in organoid technology have led to a vigorous movement towards utilizing it as a substitute for animal experiments. Organoid technology offers versatile applications, particularly in toxicity testing of pharmaceuticals o...
Sun-Ju Ahn,Sungin Lee,Dayeon Kwon et al.
Sun-Ju Ahn et al.
An organoid is a self-organized three-dimensional structure derived from stem cells that mimics the structure, cell composition, and functional characteristics of specific organs and tissues and is used for evaluating the safety and effecti...
Guidelines for Packaging, Transport, and Storage of Source Cells for Organoids [0.03%]
器官oid源细胞的包装、运输和储存指南
Sungin Lee,Dayeon Kwon,Han Byeol Lee et al.
Sungin Lee et al.
This paper presents guidelines for the systematic management of packaging, storage, transportation, and traceability of source cells used for organoid research. Given the important role of source cells in organoid studies, it is important t...
Gastric Organoid, a Promising Modeling for Gastric Stem Cell Homeostasis and Therapeutic Application [0.03%]
胃类器官在胃干细胞稳态及治疗应用中的研究展望
Subin Lee,Jang-Hyun Choi,So-Yeon Park et al.
Subin Lee et al.
The elucidation of the pathophysiology underlying various diseases necessitates the development of research platforms that faithfully mimic in vivo conditions. Traditional model systems such as two-dimensional cell cultures and animal model...
Energy Metabolism in Human Pluripotent Stem and Differentiated Cells Compared Using a Seahorse XF96 Extracellular Flux Analyzer [0.03%]
人多能干细胞及其分化细胞的能量代谢比较研究——基于赛贝奇XF96细胞能量分析仪的方法
Hyun Kyu Kim,Yena Song,Minji Kye et al.
Hyun Kyu Kim et al.
Evaluating cell metabolism is crucial during pluripotent stem cell (PSC) differentiation and somatic cell reprogramming as it affects cell fate. As cultured stem cells are heterogeneous, a comparative analysis of relative metabolism using e...
Pancreatic Diseases: Genetics and Modeling Using Human Pluripotent Stem Cells [0.03%]
基于人多能干细胞的遗传性和胰腺疾病建模性研究
Yuri Lee,Kihyun Lee
Yuri Lee
Pancreas serves endocrine and exocrine functions in the body; thus, their pathology can cause a broad range of irreparable consequences. Endocrine functions include the production of hormones such as insulin and glucagon, while exocrine fun...
IGF-1 Induces Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells by Promoting SOX4 via the MAPK/ERK Pathway [0.03%]
胰岛素样生长因子通过MAPK/ERK信号促进SOX4的表达从而诱导大鼠骨髓间充质干细胞成骨分化
Jingjun Zeng,Jun Deng,Chong He et al.
Jingjun Zeng et al.
Tissue engineering envisions functional substitute creation for damaged tissues. Insulin-like growth factor-1 (IGF-1) plays roles in bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation (OD), and we investigated its specific ...
Assessment of the Therapeutic Effectiveness of Glutathione-Enhanced Mesenchymal Stem Cells in Rat Models of Chronic Bladder Ischemia-Induced Overactive Bladder and Detrusor Underactivity [0.03%]
评估谷胱甘肽增强的间充质干细胞治疗慢性膀胱缺血诱导的过度活跃膀胱和膀胱逼尿肌低合同效性的疗效
Jung Hyun Shin,Hwan Yeul Yu,Hyungu Kwon et al.
Jung Hyun Shin et al.
Overactive bladder (OAB) and detrusor underactivity (DUA) are representative voiding dysfunctions with a chronic nature and limited treatment modalities, and are ideal targets for stem cell therapy. In the present study, we investigated the...
Impaired Osteogenesis in Human Induced Pluripotent Stem Cells with Acetaldehyde Dehydrogenase 2 Mutations [0.03%]
乙醛脱氢酶2基因突变型诱导多能干细胞成骨分化功能受损
Jooyoung Lim,Heeju Han,Se In Jung et al.
Jooyoung Lim et al.
Acetaldehyde dehydrogenase 2 (ALDH2) is the second enzyme involved in the breakdown of acetaldehyde into acetic acid during the process of alcohol metabolism. Roughly 40% of East Asians carry one or two ALDH2*2 alleles, and the presence of ...
Suppression of Glioblastoma Stem Cell Potency and Tumor Growth via LRRK2 Inhibition [0.03%]
通过LRRK2抑制作用压制胶质母细胞瘤干细胞活性和肿瘤生长
Saewhan Park,Kyung-Hee Kim,Yun-Hee Bae et al.
Saewhan Park et al.
Leucine-rich repeat kinase 2 (LRRK2), a large GTP-regulated serine/threonine kinase, is well-known for its mutations causing late-onset Parkinson's disease. However, the role of LRRK2 in glioblastoma (GBM) carcinogenesis has not yet been fu...