Inducing Pluripotency in Somatic Cells: Historical Perspective and Recent Advances [0.03%]
诱导体细胞多能性：历史回顾与最新进展
Junmyeong Park,Jueun Kim,Borami Shin et al.
Junmyeong Park et al.
Inducing pluripotency in somatic cells is mediated by the Yamanaka factors Oct4, Sox2, Klf4, and c-Myc. The resulting induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine by virtue of their ability to differen...
Navigating the Landscape of Intestinal Regeneration: A Spotlight on Quiescence Regulation and Fetal Reprogramming [0.03%]
肠道再生领域的探索：静息调控与胎儿重编程的焦点
Su-Jeong Oh,Yoojin Seo,Hyung-Sik Kim
Su-Jeong Oh
Tissue-specific adult stem cells are pivotal in maintaining tissue homeostasis, especially in the rapidly renewing intestinal epithelium. At the heart of this process are leucine-rich repeat-containing G protein-coupled receptor 5-expressin...
Exosomes Reshape the Osteoarthritic Defect: Emerging Potential in Regenerative Medicine-A Review [0.03%]
外泌体重塑骨关节炎缺陷：在再生医学中的新兴潜力-评论
Jaishree Sankaranarayanan,Seok Cheol Lee,Hyung Keun Kim et al.
Jaishree Sankaranarayanan et al.
Osteoarthritis (OA) is a joint disorder caused by wear and tear of the cartilage that cushions the joints. It is a progressive condition that can cause significant pain and disability. Currently, there is no cure for OA, though there are tr...
Human Pluripotent Stem Cell-Derived Retinal Organoids: A Viable Platform for Investigating the Efficacy of Adeno-Associated Virus Gene Therapy [0.03%]
人多能干细胞衍生的视网膜类器官：研究腺相关病毒基因疗法功效的可行平台
Hyeon-Jin Na,Jae-Eun Kwon,Seung-Hyun Kim et al.
Hyeon-Jin Na et al.
With recent advances in adeno-associated virus (AAV)-based gene therapy, efficacy and toxicity screening have become essential for developing gene therapeutic drugs for retinal diseases. Retinal organoids from human pluripotent stem cells (...
Cytoplasmatic Localization of Six1 in Male Testis and Spermatogonial Stem Cells [0.03%]
Six1在雄性睾丸和精原干细胞中的细胞质定位
Mingming Qin,Linzi Ma,Wenjing Du et al.
Mingming Qin et al.
Sine oculis homeobox 1 (Six1) is an important factor for embryonic development and carcinoma malignancy. However, the localization of Six1 varies due to protein size and cell types in different organs. In this study, we focus on the express...
Immune-Epithelial Cell Interactions during Epidermal Regeneration, Repair, and Inflammatory Diseases [0.03%]
表皮再生、修复及炎症疾病中的免疫上皮细胞相互作用
Axel D Schmitter-Sánchez,Sangbum Park
Axel D Schmitter-Sánchez
The multiple layers of the skin cover and protect our entire body. Among the skin layers, the epidermis is in direct contact with the outer environment and serves as the first line of defense. The epidermis functions as a physical and immun...
Human Endometrial Regenerative Cells for Neurological Disorders: Hype or Hope? [0.03%]
人子宫内膜再生细胞对神经性疾病治疗的应用：炒作还是希望？
Javad Momeni,Elnaz Naserzadeh,Ali Sepehrinezhad et al.
Javad Momeni et al.
Despite enormous efforts, no effective medication has been found to significantly halt or even slow the progression of neurological diseases, such as acquired (e.g., traumatic brain injury, spinal cord injury, etc.) and chronic (e.g., Parki...
Unleashing the Power of Undifferentiated Induced Pluripotent Stem Cell Bioprinting: Current Progress and Future Prospects [0.03%]
未分化诱导多能干细胞生物打印的力量释放：当前进展与未来展望
Boyoung Kim,Jiyoon Kim,Soah Lee
Boyoung Kim
Induced pluripotent stem cell (iPSC) technology has revolutionized various fields, including stem cell research, disease modeling, and regenerative medicine. The evolution of iPSC-based models has transitioned from conventional two-dimensio...
Host-Microbe Interactions Regulate Intestinal Stem Cells and Tissue Turnover in Drosophila [0.03%]
宿主-微生物相互作用调节果蝇的肠道干细胞和组织更新
Ji-Hoon Lee
Ji-Hoon Lee
With the activity of intestinal stem cells and continuous turnover, the gut epithelium is one of the most dynamic tissues in animals. Due to its simple yet conserved tissue structure and enteric cell composition as well as advanced genetic ...
Amna Rashid Tariq,Mijung Lee,Manho Kim
Amna Rashid Tariq
An enormous amount of current data has suggested involvement of endothelial progenitor cells (EPCs) in neovasculogenesis in both human and animal models. EPC level is an indicator of possible cardiovascular risk such as Alzheimer disease. E...