Therapeutic Effect of Pioglitazone-Pretreated Human Wharton's Jelly-Derived Mesenchymal Stem Cells in a Rat Tendon Injury Model [0.03%]
二甲双胍预处理的人胎盘华通胶间充质干细胞对大鼠肌腱损伤的治疗作用研究
Won Kim,Soo Kim,Seul Ki Lee et al.
Won Kim et al.
The clinical application of mesenchymal stem cells (MSCs) has several limitations owing to their less therapeutic efficacy. Effect enhancement and MSCs from new sources might help in overcoming these limitations. The aim of the present stud...
Efficacy and Safety of Low-Molecular-Weight Collagen Peptide GT for Improving Hair Condition in Individuals with Damaged Hair: A Randomized, Double-Blind, Placebo-Controlled Trial [0.03%]
低分子量胶原肽GT改善受损发质功效性和安全性研究：随机、双盲、安慰剂对照试验
Taek-Kyong Kim,Jintaek Oh,Yoon-Su Ha et al.
Taek-Kyong Kim et al.
Addressing hair damage is essential for maintaining overall hair and scalp health. Previous studies have suggested that low-molecular-weight collagen peptides may support hair follicle biology through regulation of extracellular matrix home...
Human-Relevant Microphysiological Systems: Evidence for Defined Contexts of Use [0.03%]
人体相关的微生理系统：使用情境的依据
Minseo Byeon,Eunseo Park,Jihoon Ko
Minseo Byeon
The FDA Modernization Act has accelerated the transition from animal-based testing toward human-relevant new approach methodologies in drug development, shifting attention from technological feasibility to regulatory implementation. Among t...
Fibroblast Growth Factor Signaling in Lung Diseases: From Biological Roles to Therapeutic Delivery Strategies [0.03%]
肺部疾病中的成纤维细胞生长因子信号通路：从生物学功能到治疗递送策略
Se Bi Lee,Young Her,Dae-Hee Lee et al.
Se Bi Lee et al.
As human longevity continues to increase globally, the prevalence of age-related deterioration and associated chronic lung diseases has risen in parallel. Unlike many organs, the lung is continuously exposed to environmental insults, leadin...
Lineage-Driven Understanding of Human Pericyte Heterogeneity in Vascular Modeling and Regeneration [0.03%]
谱系驱动的人类周细胞异质性在血管建模和再生中的作用理解
Seungyeon Lee,Chan Mi Baek,Somin Lee et al.
Seungyeon Lee et al.
Pericytes are mural cells embedded within the microvascular wall that regulate endothelial stabilization, angiogenesis, and vascular permeability. Once regarded as a relatively uniform vascular support population, pericytes are now recogniz...
A Cerebral Organoid Model of Familial Alzheimer's Disease Using Amyloid Precursor Protein Mutation, Val669Leu (APPSeoul) [0.03%]
包含β淀粉样蛋白前体蛋白谷氨酸693赖氨酰变异的人类阿尔茨海默病脑类器官模型（APPSeoul）
Won Hee Jung,Seung Tack Oh,Mu Seog Choe et al.
Won Hee Jung et al.
Various animal and cellular Alzheimer's disease (AD) models harboring familial AD (fAD) mutations have been developed and widely used for AD research. In this study, we established an AD cerebral organoid (CO) model using a novel Val669Leu ...
CXCL14 Enhances Myocyte Fusion and Activates the FAK-ERK5 Signaling Pathway in Skeletal Muscle Stem Cells and Myoblasts [0.03%]
CXCL14通过激活FAK-ERK5信号通路促进骨骼肌干细胞和肌管细胞融合
Nurkyz Alymkulova,Younjeong Oh,Jennifer Fransisca et al.
Nurkyz Alymkulova et al.
Skeletal muscle regeneration is essential for maintaining muscle function throughout life and is regulated by numerous growth factors, cytokines and their associated signaling pathways. In this study, we investigated the role of C-X-C motif...
Genome-Wide Characterization of Recombinant AAV6 Vector Integration in Human CD34＋ Cells [0.03%]
人CD34＋细胞中重组AAV6载体整合的全基因组表征
Hyeon Jeong Lee,Nayoung Park,In-Byung Park et al.
Hyeon Jeong Lee et al.
Several viral vectors have been developed for gene therapy due to their high transduction efficiency, but some integrate into the host genome, raising safety concerns. Recent studies have identified recombinant adeno-associated virus seroty...
Recent Advances in Genetically Engineered Mouse Models of Melanoma: Insights into Tumor Initiation and Oncogenic Signaling Pathways [0.03%]
近期黑色素瘤基因工程小鼠模型的研究进展：肿瘤发生及致癌信号转导途径的启示
Hyeonji Choi,Jung Hyun Lee,Hye Ji Cha et al.
Hyeonji Choi et al.
Genetically engineered mouse (GEM) models are essential for elucidating the cellular and molecular mechanisms underlying various human diseases. Because mouse skin closely resembles the structure and lineage organization of human skin, mela...
Vascularized Brain Organoids: Advances in Engineering Human Neurovascular Models [0.03%]
血管化脑类器官：工程人体神经血管模型的新进展
Hee Young Kim,Jung Eun Lee,Seung Ho Yang et al.
Hee Young Kim et al.
Brain organoids have emerged as an important platform for studying human neurodevelopment and neurological disorders, yet their physiological relevance remains limited by the absence of a functional vascular network. Recent efforts therefor...