Altered Properties of Bone Marrow-Derived Mesenchymal Stem Cells Exposed to Serum from Patients with Acute-On-Chronic Liver Failure [0.03%]
慢性急性肝功能衰竭患者血清暴露对骨髓间充质干细胞的影响
Wenxin Zhang,Shurong Liu,Zhiru Wang et al.
Wenxin Zhang et al.
Acute-on-chronic liver failure (ACLF) is a high-mortality syndrome characterized by acute decompensation of liver function. Oxidative stress exerts a pivotal regulatory role in ACLF. Mesenchymal stem cell (MSC)-based therapy is a promising ...
Retraction Notice to: Improvement of Human Sperm Vacuolization and DNA Fragmentation Co-Cultured with Adipose-Derived Mesenchymal Stem Cell Secretome: In Vitro Effect [0.03%]
撤稿通知：改善人源精子 vacuum和DNA片段与脂肪来源间充质干细胞分泌组共培养的体外效应
Robert Bader,José-Noel Ibrahim,Ali Mourad et al.
Robert Bader et al.
Targeting Oxidative Stress during the Post-Thawing Recovery Window Improves Cryopreservation Outcomes in Human Neural Organoids [0.03%]
冻融后 targeting 氧化应激可改善人神经器官体的 cryopreservation 结果
Yejin Kwon,Aeri Shin,Garam Kim et al.
Yejin Kwon et al.
Neural organoids serve as critical in vitro models for recapitulating the structural and functional complexities of the human nervous system. However, the transition toward high-throughput drug screening and industrial-scale applications is...
Multiscale Convergence of Signaling, Epigenetic, and Environmental Networks in Mammalian Palatogenesis and Cleft Palate Pathogenesis [0.03%]
哺乳动物腭发育和腭裂发生过程中信号通路、表观遗传及环境网络的多尺度汇聚模式研究进展
Hyung-Jin Won,Beomjong Song,Yujeong Song et al.
Hyung-Jin Won et al.
Palatogenesis is tightly regulated at cellular and molecular levels. Cranial neural crest cells (CNCCs), multipotent stem cells that generate most palatal mesenchyme, self-renew, decide fate, and differentiate under cues from their stem cel...
Sang Hyeon Woo,Sehyun Chae,Byung-Ho Rhie et al.
Sang Hyeon Woo et al.
Long-term culture of human pluripotent stem cells (hPSCs) can lead to spontaneous mutations, genomic abnormalities, and alterations in gene expression, thereby compromising their self-renewal and pluripotency. Thus, optimizing the long-term...
Stem Cell-Based Regeneration of Atrophied Vocal Folds after Recurrent Laryngeal Nerve Injury [0.03%]
喉返神经损伤后声带萎缩的干细胞再生疗法
Min Ji Lee,Se-Young Oh,Soo Yeon Jung et al.
Min Ji Lee et al.
This study evaluated the therapeutic potential of calcium hydroxylapatite (CaHA) and tonsil-derived mesenchymal stem cells (TMSCs) suspended in hyaluronic acid (HA) for regenerating atrophied vocal fold in a rabbit model of recurrent laryng...
Neuroprotective Effects of Transplanted Induced Pluripotent Stem Cell-Derived Neural Precursors in Huntington's Disease Models [0.03%]
诱导多能干细胞来源的神经前体细胞移植在亨廷顿舞蹈病模型中的神经保护作用
Hyeonjoong Jeon,Il-Shin Lee,Dong Gyu Lee et al.
Hyeonjoong Jeon et al.
Huntington's disease (HD) is characterized by progressive striatal degeneration associated with mutant huntingtin (mHTT)-related proteostatic disruption and chronic neuroinflammation. Although mHTT-lowering approaches hold therapeutic promi...
Exploring the Potential of Wharton's Jelly-Derived Mesenchymal Stem Cells as a Therapeutic Approach for Preterm Premature Rupture of Membranes [0.03%]
威坛胶原干细胞作为治疗胎膜早破的潜在疗法研究
Hyeongseop Kim,Hyunju Kim,Suyeon Jeon et al.
Hyeongseop Kim et al.
Preterm premature rupture of membranes (PPROM) is a major cause of preterm birth and neonatal morbidity, with no established treatment to restore membrane integrity. Mesenchymal stem cells (MSCs), known for their regenerative and immunomodu...
Investigating the Causal Links between the Aging Process and Alzheimer's Disease Pathogenesis [0.03%]
探究衰老过程与阿尔茨海默病发病机制之间的因果关系
Jaewoo Seok,Hyein Lee,Jinsoo Seo
Jaewoo Seok
As global societies age, the prevalence of neurodegenerative disorders, such as Alzheimer's disease, is rapidly increasing, intensifying the need to understand the mechanisms of aging and their contribution to these conditions. Consequently...
PRPS1 (p.V42L) Mutation in Arts Syndrome Induces Aberrant Neural Stem Cell Development and Neuronal Senescence-Like Phenotype: Rescue by Nicotinamide Mononucleotide Supplementation [0.03%]
PRPS1(p.V42L)基因突变通过异常的神经干细胞发育和神经元衰老样表型诱导ARTS综合征：烟酸单核苷酸补充对其有治疗作用
Ji-Hee Kim,Su-Jung Park,Jeong-A Lee et al.
Ji-Hee Kim et al.
Arts syndrome is a rare X-linked recessive neurodevelopmental disorder arising from pathogenic variants in PRPS1, which encodes phosphoribosyl pyrophosphate synthetase 1-an enzyme essential for de novo nucleotide biosynthesis. Affected indi...