Energy Metabolism in Human Pluripotent Stem and Differentiated Cells Compared Using a Seahorse XF96 Extracellular Flux Analyzer [0.03%]
人多能干细胞及其分化细胞的能量代谢比较研究——基于赛贝奇XF96细胞能量分析仪的方法
Hyun Kyu Kim,Yena Song,Minji Kye et al.
Hyun Kyu Kim et al.
Evaluating cell metabolism is crucial during pluripotent stem cell (PSC) differentiation and somatic cell reprogramming as it affects cell fate. As cultured stem cells are heterogeneous, a comparative analysis of relative metabolism using e...
Pancreatic Diseases: Genetics and Modeling Using Human Pluripotent Stem Cells [0.03%]
基于人多能干细胞的遗传性和胰腺疾病建模性研究
Yuri Lee,Kihyun Lee
Yuri Lee
Pancreas serves endocrine and exocrine functions in the body; thus, their pathology can cause a broad range of irreparable consequences. Endocrine functions include the production of hormones such as insulin and glucagon, while exocrine fun...
IGF-1 Induces Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells by Promoting SOX4 via the MAPK/ERK Pathway [0.03%]
胰岛素样生长因子通过MAPK/ERK信号促进SOX4的表达从而诱导大鼠骨髓间充质干细胞成骨分化
Jingjun Zeng,Jun Deng,Chong He et al.
Jingjun Zeng et al.
Tissue engineering envisions functional substitute creation for damaged tissues. Insulin-like growth factor-1 (IGF-1) plays roles in bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation (OD), and we investigated its specific ...
Assessment of the Therapeutic Effectiveness of Glutathione-Enhanced Mesenchymal Stem Cells in Rat Models of Chronic Bladder Ischemia-Induced Overactive Bladder and Detrusor Underactivity [0.03%]
评估谷胱甘肽增强的间充质干细胞治疗慢性膀胱缺血诱导的过度活跃膀胱和膀胱逼尿肌低合同效性的疗效
Jung Hyun Shin,Hwan Yeul Yu,Hyungu Kwon et al.
Jung Hyun Shin et al.
Overactive bladder (OAB) and detrusor underactivity (DUA) are representative voiding dysfunctions with a chronic nature and limited treatment modalities, and are ideal targets for stem cell therapy. In the present study, we investigated the...
Impaired Osteogenesis in Human Induced Pluripotent Stem Cells with Acetaldehyde Dehydrogenase 2 Mutations [0.03%]
乙醛脱氢酶2基因突变型诱导多能干细胞成骨分化功能受损
Jooyoung Lim,Heeju Han,Se In Jung et al.
Jooyoung Lim et al.
Acetaldehyde dehydrogenase 2 (ALDH2) is the second enzyme involved in the breakdown of acetaldehyde into acetic acid during the process of alcohol metabolism. Roughly 40% of East Asians carry one or two ALDH2*2 alleles, and the presence of ...
Suppression of Glioblastoma Stem Cell Potency and Tumor Growth via LRRK2 Inhibition [0.03%]
通过LRRK2抑制作用压制胶质母细胞瘤干细胞活性和肿瘤生长
Saewhan Park,Kyung-Hee Kim,Yun-Hee Bae et al.
Saewhan Park et al.
Leucine-rich repeat kinase 2 (LRRK2), a large GTP-regulated serine/threonine kinase, is well-known for its mutations causing late-onset Parkinson's disease. However, the role of LRRK2 in glioblastoma (GBM) carcinogenesis has not yet been fu...
Human Endometrium Derived Mesenchymal Stem Cells with Aberrant NOD1 Expression Are Associated with Ectopic Endometrial Lesion Formation [0.03%]
人子宫内膜源间充质干细胞中异位表达的NOD1与病灶形成有关
Chunmei Li,Suiyu Luo,Ai Guo et al.
Chunmei Li et al.
Nucleotide-binding oligomerization domain 1 (NOD1), a cytosolic pattern recognition receptor protein, plays a crucial role in innate immune responses. However, the functional expression of NOD1 in mesenchymal stem cells (MSCs) derived from ...
A Roadmap for Selecting and Utilizing Optimal Features in scRNA Sequencing Data Analysis for Stem Cell Research: A Comprehensive Review [0.03%]
单细胞RNA测序数据在干细胞研究中的特征选择和利用综述性文章：面向应用的路线图
Maath Alani,Hamza Altarturih,Selin Pars et al.
Maath Alani et al.
Stem cells and the cells they produce are unique because they vary from one cell to another. Traditional methods of studying cells often overlook these differences. However, the development of new technologies for studying individual cells ...
Crosstalk between Signaling Pathways and Energy Metabolism in Pluripotency [0.03%]
多能性中信号通路与能量代谢之间的相互作用
Keun-Tae Kim,Seong-Min Kim,Hyuk-Jin Cha
Keun-Tae Kim
The sequential change from totipotency to multipotency occurs during early mammalian embryo development. However, due to the lack of cellular models to recapitulate the distinct potency of stem cells at each stage, their molecular and cellu...
Min Seong Kim,Subeen Yoon,Jiwoo Choi et al.
Min Seong Kim et al.
Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of midbrain dopaminergic neurons, leading to motor symptoms. While current treatments provide limited relief, they don't alter disease progression. Stem cel...