The Differential Developmental Neurotoxicity of Valproic Acid on Anterior and Posterior Neural Induction of Human Pluripotent Stem Cells [0.03%]
人多能干细胞前、后神经诱导的分化型发育神经毒物的区别化发展神经毒性瓦尔普酸
Jeongah Kim,Si-Hyung Park,Woong Sun
Jeongah Kim
Valproic acid (VPA), widely used as an antiepileptic drug, exhibits developmental neurotoxicity when exposure occurs during early or late pregnancy, resulting in various conditions ranging from neural tube defects to autism spectrum disorde...
Usp7 Regulates Glial Lineage Cell-Specific Transcription Factors by Modulating Histone H2B Monoubiquitination [0.03%]
Usp7通过调节组蛋白H2B单泛素化来调控神经胶质谱系特异性转录因子
Dong-Ho Kim,Sammy L Kim,Vijai Singh et al.
Dong-Ho Kim et al.
Histone H2B monoubiquitination (H2Bub1) is a dynamic posttranslational modification which are linked to DNA damage and plays a key role in a wide variety of regulatory transcriptional programs. Cancer cells exhibit a variety of epigenetic c...
Glutathione Dynamics in the Tumor Microenvironment: A Potential Target of Cancer Stem Cells and T Cells [0.03%]
肿瘤微环境中谷胱甘肽的动态变化：癌症干细胞和T细胞的潜在靶点
Youngjun Park,Eui Man Jeong
Youngjun Park
Glutathione (GSH), the main cellular antioxidant, dynamically influences tumor growth, metastasis, and resistance to therapy in the tumor microenvironment (TME), which comprises cancer cells, immune cells, stromal cells, and non-cellular co...
Lung Cancer Organoid System to Evaluate the Cytotoxicity of Natural Killer Cells [0.03%]
肺癌类器官系统评估自然杀伤细胞的细胞毒性
Byungmoo Oh,Jeongmin Kim,Namwoog Kim et al.
Byungmoo Oh et al.
Natural killer (NK) cells are gaining growing attention due to their promise for immunotherapy. A fast and accurate system is needed to test NK cell biology and their therapeutic application. Here, we report a lung cancer organoid-based sys...
Sun-Ju Ahn
Sun-Ju Ahn
Seunghee Lee,Yeri Alice Rim,Juryun Kim et al.
Seunghee Lee et al.
To address the limitations of animal testing, scientific research is increasingly focused on developing alternative testing methods. These alternative tests utilize cells or tissues derived from animals or humans for in vitro testing, as we...
Taehwan Kwak,Si-Hyung Park,Siyoung Lee et al.
Taehwan Kwak et al.
This study offers a comprehensive overview of brain organoids for researchers. It combines expert opinions with technical summaries on organoid definitions, characteristics, culture methods, and quality control. This approach aims to enhanc...
Hyang-Ae Lee,Dong-Hun Woo,Do-Sun Lim et al.
Hyang-Ae Lee et al.
Cardiac organoids have emerged as invaluable tools for assessing the impact of diverse substances on heart function. This report introduces guidelines for general requirements for manufacturing cardiac organoids and conducting cardiac organ...
Kyungtae Lim,Mi-Ok Lee,Jinwook Choi et al.
Kyungtae Lim et al.
The objective of standard guideline for utilization of human lung organoids is to provide the basic guidelines required for the manufacture, culture, and quality control of the lung organoids for use in non-clinical efficacy and inhalation ...
Hye-Ran Moon,Seon Ju Mun,Tae Hun Kim et al.
Hye-Ran Moon et al.
Recent amendments to regulatory frameworks have placed a greater emphasis on the utilization of in vitro testing platforms for preclinical drug evaluations and toxicity assessments. This requires advanced tissue models capable of accurately...