An Efficient Endothelial Cell Differentiation Protocol Using Bioactive Lipid O-Cyclic Phytosphingosine-1-Phosphate in Human Embryonic Stem Cells [0.03%]
一种在人胚胎干细胞中利用生物活性脂质O-环法尼基鞘氨醇-1-磷酸高效诱导内皮细胞分化的方案
Ki-Sang Jo,Won-Jun Jo,Ainsley Mike Antao et al.
Ki-Sang Jo et al.
Bioactive lipids like sphingosine-1-phosphate (S1P) and lysophosphatidic acid have gained significant attention as signaling molecules with regulatory roles in stem cell proliferation and differentiation. The novel chemically synthesized sp...
Seongje Hong,Dong-Sung Lee,Geun-Woo Bae et al.
Seongje Hong et al.
Published Erratum
International journal of stem cells. 2024 Nov 30;17(4):449. DOI:10.15283/23045C 2024
Generation of an Isogenic Hereditary Hemorrhagic Telangiectasia Model via Prime Editing in Human Induced Pluripotent Stem Cells [0.03%]
基于人诱导多能干细胞的基因组 prime 编辑技术建立遗传性出血性毛细血管扩张症同源模型
Min Woo Kim,Kyu Sik Jeong,Jin Kim et al.
Min Woo Kim et al.
Prime editing (PE) is a recently developed genome-editing technique that enables versatile editing. Despite its flexibility and potential, applying PE in human induced pluripotent stem cells (hiPSCs) has not been extensively addressed. Gene...
Applications of Single-Cell Omics Technologies for Induced Pluripotent Stem Cell-Based Cardiovascular Research [0.03%]
单细胞组学技术在基于诱导多能干细胞的心血管疾病研究中的应用
Hyunjoon Kim,Sohee Choi,HyoJung Heo et al.
Hyunjoon Kim et al.
Single-cell omics technologies have transformed our investigation of genomic, transcriptomic, and proteomic landscapes at the individual cell level. In particular, the application of single-cell RNA sequencing has unveiled the complex trans...
The Characterization and Regulation of Schwann Cells in the Tooth Germ Development and Odontogenic Differentiation [0.03%]
牙胚发生及牙原发分化中施万细胞的特征及时空调控机制研究
Jing He,Ting Wang,Danyang Liu et al.
Jing He et al.
Schwann cells (SCs), a type of glial cell in the peripheral nervous system, can serve as a source of mesenchymal stem cells (MSCs) to repair injured pulp. This study aimed to investigate the role of SCs in tooth germ development and repair ...
Eun Jin Seo,Soyoung Park,Eungyung Lee et al.
Eun Jin Seo et al.
Mesenchymal stem cells in the dental tissue indicate a disposition for differentiation into diverse dental lineages and contain enormous potential as the important means for regenerative medicine in dentistry. Among various dental tissues, ...
The Differential Developmental Neurotoxicity of Valproic Acid on Anterior and Posterior Neural Induction of Human Pluripotent Stem Cells [0.03%]
人多能干细胞前、后神经诱导的分化型发育神经毒物的区别化发展神经毒性瓦尔普酸
Jeongah Kim,Si-Hyung Park,Woong Sun
Jeongah Kim
Valproic acid (VPA), widely used as an antiepileptic drug, exhibits developmental neurotoxicity when exposure occurs during early or late pregnancy, resulting in various conditions ranging from neural tube defects to autism spectrum disorde...
Usp7 Regulates Glial Lineage Cell-Specific Transcription Factors by Modulating Histone H2B Monoubiquitination [0.03%]
Usp7通过调节组蛋白H2B单泛素化来调控神经胶质谱系特异性转录因子
Dong-Ho Kim,Sammy L Kim,Vijai Singh et al.
Dong-Ho Kim et al.
Histone H2B monoubiquitination (H2Bub1) is a dynamic posttranslational modification which are linked to DNA damage and plays a key role in a wide variety of regulatory transcriptional programs. Cancer cells exhibit a variety of epigenetic c...
Glutathione Dynamics in the Tumor Microenvironment: A Potential Target of Cancer Stem Cells and T Cells [0.03%]
肿瘤微环境中谷胱甘肽的动态变化：癌症干细胞和T细胞的潜在靶点
Youngjun Park,Eui Man Jeong
Youngjun Park
Glutathione (GSH), the main cellular antioxidant, dynamically influences tumor growth, metastasis, and resistance to therapy in the tumor microenvironment (TME), which comprises cancer cells, immune cells, stromal cells, and non-cellular co...
Lung Cancer Organoid System to Evaluate the Cytotoxicity of Natural Killer Cells [0.03%]
肺癌类器官系统评估自然杀伤细胞的细胞毒性
Byungmoo Oh,Jeongmin Kim,Namwoog Kim et al.
Byungmoo Oh et al.
Natural killer (NK) cells are gaining growing attention due to their promise for immunotherapy. A fast and accurate system is needed to test NK cell biology and their therapeutic application. Here, we report a lung cancer organoid-based sys...