Advanced Animal Replacement Testing Strategies Using Stem Cell and Organoids [0.03%]
使用干细胞和类器官进行高级动物替代测试策略
Chang-Jin Lee,Yoojun Nam,Yeri Alice Rim et al.
Chang-Jin Lee et al.
The increasing ethical concerns and regulatory restrictions surrounding animal testing have accelerated the development of advanced in vitro models that more accurately replicate human physiology. Among these, stem cell-based systems and or...
PML Regulated HIF1AN Ubiquitination and Activated PI3K/AKT Pathway to Promote Bone Marrow Mesenchymal Stem Cells Osteogenic Differentiation [0.03%]
PML调控HIF1AN泛素化及激活PI3K/AKT通路促进骨髓间充质干细胞成骨分化
Xian-Pei Zhou,Qi-Wei Li,Zi-Zhen Shu et al.
Xian-Pei Zhou et al.
Osteoporosis (OP) is a metabolic disease caused by osteogenesis and bone resorption disorders. Promyelocytic leukemia protein (PML) was a vital regulator of cellular functions. However, the function of PML in OP remains unknown. Our researc...
Juhyeon Nam,Byungkuk Min,Areum Baek et al.
Juhyeon Nam et al.
Regeneration is a process that restores the structure and function of injured tissues or organs. Regenerative capacities vary significantly across species, with amphibians and fish demonstrating a high regenerative capacity even after sever...
Collagen Scaffold Augments the Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells in a Rat Model of Intrauterine Adhesion [0.03%]
胶原支架提高了人脐源间充质干细胞在宫腔粘连大鼠模型中的治疗效果
Linzhi Gao,Guifang Jiang,Enming Liang et al.
Linzhi Gao et al.
Intrauterine adhesion (IUA) caused by endometrial injury is the most common cause of female uterine infertility. Current treatments offer limited clinical benefits. In this study, we investigated the role of human umbilical cord mesenchymal...
Mesenchymal Stem Cells Mediated Suppression of GREM2 Inhibits Renal Epithelial-Mesenchymal Transition and Attenuates the Progression of Diabetic Kidney Disease [0.03%]
间充质干细胞介导的GREM2抑制调控肾上皮细胞间充质转化并延缓糖尿病肾脏疾病进展
Myoung Seok Ko,Ji-Young Yun,Serin Kim et al.
Myoung Seok Ko et al.
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide. Despite advancements in various treatments, the prevalence of DKD continues to rise, leading to a significant increase in the demand for dialysis and k...
The Effect of Nerve Growth Factor on Cartilage Fibrosis and Hypertrophy during In Vitro Chondrogenesis Using Induced Pluripotent Stem Cells [0.03%]
神经生长因子对诱导多能干细胞体外软骨分化过程中纤维化和肥大的影响
Se In Jung,Si Hwa Choi,Jang-Woon Kim et al.
Se In Jung et al.
Nerve growth factor (NGF) is a neurotrophic factor usually involved in the survival, differentiation, and growth of sensory neurons and nociceptive function. Yet, it has been suggested to play a role in the pathogenesis of osteoarthritis (O...
Probiotic-Derived P8 Protein: Promoting Proliferation and Migration in Stem Cells and Keratinocytes [0.03%]
益生菌衍生的P8蛋白促进干细胞和角质形成细胞增殖及迁移
Soo Bin Jang,Yoojung Kim,Han Ceol Yeo et al.
Soo Bin Jang et al.
Probiotics exert various effects on the body and provide different health benefits. Previous reports have demonstrated that the P8 protein (P8), isolated from Lactobacillus rhamnosus, has anticancer properties. However, its efficacy in stem...
Thermostable bFGF Improves Cell Lifespan by Enhancing Cell Activity in the Long-Term Culture of Human Orbicularis Oculi Stem Cells [0.03%]
热稳定bFGF通过增强长期培养的人眼轮匝肌干细胞活性来改善细胞寿命
Geun-Ho Kang,Yeo Kyung Shin,Kyung Min Lim et al.
Geun-Ho Kang et al.
Stem cells derived from human orbicularis oculi muscle (hOOM) are a valuable resource for cell therapy. However, when stem cells are continuously cultured, their abilities tend to deteriorate over time. One method to address this issue is t...
Efficient Treatment of Psoriasis Using Conditioned Media from Mesenchymal Stem Cell Spheroids Cultured to Produce Transforming Growth Factor- β 1-Enriched Small-Sized Extracellular Vesicles [0.03%]
高效治疗银屑病的条件培养基中含有的由间充质干细胞球体产生并富含转化生长因子- β 1的小尺寸细胞外囊泡
Myeongjin Song,Kyung Min Lim,Kwonwoo Song et al.
Myeongjin Song et al.
Psoriasis is a common chronic inflammatory disease in which keratinocytes proliferate abnormally due to excessive immune action. Psoriasis can be associated with various comorbidities and has a significant impact on health-related quality o...
Application of Deep Neural Networks in the Manufacturing Process of Mesenchymal Stem Cells Therapeutics [0.03%]
深度神经网络在间充质干细胞治疗产品制造过程中的应用研究
Dat Ngo,Jeongmin Lee,Sun Jae Kwon et al.
Dat Ngo et al.
Current image-based analysis methods for monitoring cell confluency and status depend on individual interpretations, which can lead to wide variations in the quality of cell therapeutics. To overcome these limitations, images of mesenchymal...