Induced Pluripotent Stem Cells derived CD71＋CD235a＋ Erythroblasts Were Increased by Sirtuin 1 Activator [0.03%]
诱导多能干细胞来源的CD71+CD235a+红系细胞由沉默信息调节因子1激活剂诱导增多
Changyeong Kim,Kyung Hwan Park,Soo-Been Jeon et al.
Changyeong Kim et al.
Induced pluripotent stem cells (iPSCs) are a promising cell source for regenerative medicine. Clinical applications require a large number of functional red blood cells (RBCs), making it essential to ensure the proliferation of actively div...
Kap1 Regulates Protein Stability of Nanog by Interfering with Fbxw8-Dependent Ubiquitination [0.03%]
kap1通过干扰fbxw8依赖性的泛素化调节nanog蛋白稳定性
Hye Ji Moon,Nayeon Lee,Bo Seok Lee et al.
Hye Ji Moon et al.
Nanog is a key transcription factor that regulates the self-renewal and pluripotency of embryonic stem cells (ESCs). Although Kap1 has been demonstrated to regulate the stability of stemness factors, including Oct4 and Lin28A, its role in r...
Beyond Structure: Next-Generation Electrophysiological Platforms for Functional Brain Organoids [0.03%]
超越结构：功能性脑类器官下一代电生理平台
Ji-Hyoung Cha,Keuntae Kim,Il-Joo Cho
Ji-Hyoung Cha
Brain organoids have emerged as transformative models for studying human neurodevelopment, neurological disorders, and personalized therapeutics. Central to their utility is the ability to monitor neural activity with high spatial and tempo...
Recent Applications of Lung Organoid and Lung-on-a-Chip Technologies for Evaluating the Toxicity of Fine Particulate Matter [0.03%]
肺器官体和肺芯片技术在评估细颗粒物毒理学中的最新应用
Minje Kang,Ji-Young Kim,Chan Woo Kwon et al.
Minje Kang et al.
There is mounting epidemiologic and experimental evidence of the harmful effects of exposure to fine particulate matter (PM2.5) on human lung health. However, the current utilization of in vitro two-dimensional (2D) cell culture and in vivo...
Proteomic Profiling of Exosomes Derived from Endometrial Stem Cells and Adipose-Derived Stem Cells [0.03%]
来源于子宫内膜干细胞和脂肪间充质干细胞的外泌体蛋白质组学分析
Jungwon Park,Jeongmin Lee,Yeon-Suk Kim et al.
Jungwon Park et al.
Endometrial stem cells (EnSCs) are mesenchymal stem cells (MSCs) derived from endometrial tissue and serve as a valuable MSC source, as they are naturally replenished during menstruation. Exosomes, vesicles secreted by cells, contain variou...
Regulatory Landscapes of Muscle Satellite Cells: From Mechanism to Application [0.03%]
肌卫星细胞的调控景观：从机制到应用
Jeong Eun Lee,Sang Hoon Yoon,Kwan Seob Shim et al.
Jeong Eun Lee et al.
Muscle satellite cells (SCs), also known as muscle stem cells, are crucial for the regeneration, maintenance, and growth of skeletal muscles. SCs possess a distinctive capability to self-renew and differentiate, rendering them highly promis...
Establishment of a Human Induced Pluripotent Stem Cell-Derived Cerebral Cortex Organoid Model for Neurotoxicity Assessment [0.03%]
建立一种用于神经毒性评估的人类诱导性多能干细胞来源的大脑皮层类器官模型
Seohee Park,Chang Hwan Yoon,Haeun Kim et al.
Seohee Park et al.
Human pluripotent stem cell (hPSC)-derived brain organoids have emerged as innovative models for drug screening and cytotoxicity evaluation. However, their inherent cellular heterogeneity presents challenges in isolating targeted neuronal p...
Assessment of Stem Cell Viability through Visual Analysis Coupled with Teachable Machine [0.03%]
基于视觉分析和Teachable Machine细胞存活率评估方法
Chanhyung Kim,Jisu Son,Dinesh Chaudhary et al.
Chanhyung Kim et al.
Cell viability is an indispensable aspect of cells in the field of drug discovery, cell biology, and biomedical research to assess the physiological conditions of cells such as healthiness, functionality, survivability, etc. Recently, there...
Temporal Regulation of Cytokines and Growth Factors for Optimized Hematopoietic-Lineage Specification from Human Pluripotent Stem Cells [0.03%]
人多能干细胞归 Fate向血液谱系的细胞因子和生长因子的时间调控
Jisoo Park,Hyebin Koh,Eunsu Jeon et al.
Jisoo Park et al.
Human pluripotent stem cells (hPSCs) can be used to investigate hematopoietic development and have the potential to advance cell-based therapies and to facilitate developmental biology studies. However, efficient ex vivo differentiation int...
Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches [0.03%]
利用基因编辑和诱导多能干细胞技术验证与酒精依赖相关的FYN变异的功能效应
Bilal Cakir,Yoshiaki Tanaka,Mu Seog Choe et al.
Bilal Cakir et al.
Alcohol dependence (AD) is one of the most prevalent neuropsychiatric disorders. Multiple polymorphisms in the Fyn tyrosine kinase gene (FYN) were found to be associated with AD. The function of AD-associated FYN variants remains largely un...