Proteomic Profiling of Exosomes Derived from Endometrial Stem Cells and Adipose-Derived Stem Cells [0.03%]
来源于子宫内膜干细胞和脂肪间充质干细胞的外泌体蛋白质组学分析
Jungwon Park,Jeongmin Lee,Yeon-Suk Kim et al.
Jungwon Park et al.
Endometrial stem cells (EnSCs) are mesenchymal stem cells (MSCs) derived from endometrial tissue and serve as a valuable MSC source, as they are naturally replenished during menstruation. Exosomes, vesicles secreted by cells, contain variou...
Regulatory Landscapes of Muscle Satellite Cells: From Mechanism to Application [0.03%]
肌卫星细胞的调控景观：从机制到应用
Jeong Eun Lee,Sang Hoon Yoon,Kwan Seob Shim et al.
Jeong Eun Lee et al.
Muscle satellite cells (SCs), also known as muscle stem cells, are crucial for the regeneration, maintenance, and growth of skeletal muscles. SCs possess a distinctive capability to self-renew and differentiate, rendering them highly promis...
Establishment of a Human Induced Pluripotent Stem Cell-Derived Cerebral Cortex Organoid Model for Neurotoxicity Assessment [0.03%]
建立一种用于神经毒性评估的人类诱导性多能干细胞来源的大脑皮层类器官模型
Seohee Park,Chang Hwan Yoon,Haeun Kim et al.
Seohee Park et al.
Human pluripotent stem cell (hPSC)-derived brain organoids have emerged as innovative models for drug screening and cytotoxicity evaluation. However, their inherent cellular heterogeneity presents challenges in isolating targeted neuronal p...
Assessment of Stem Cell Viability through Visual Analysis Coupled with Teachable Machine [0.03%]
基于视觉分析和Teachable Machine细胞存活率评估方法
Chanhyung Kim,Jisu Son,Dinesh Chaudhary et al.
Chanhyung Kim et al.
Cell viability is an indispensable aspect of cells in the field of drug discovery, cell biology, and biomedical research to assess the physiological conditions of cells such as healthiness, functionality, survivability, etc. Recently, there...
Temporal Regulation of Cytokines and Growth Factors for Optimized Hematopoietic-Lineage Specification from Human Pluripotent Stem Cells [0.03%]
人多能干细胞归 Fate向血液谱系的细胞因子和生长因子的时间调控
Jisoo Park,Hyebin Koh,Eunsu Jeon et al.
Jisoo Park et al.
Human pluripotent stem cells (hPSCs) can be used to investigate hematopoietic development and have the potential to advance cell-based therapies and to facilitate developmental biology studies. However, efficient ex vivo differentiation int...
Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches [0.03%]
利用基因编辑和诱导多能干细胞技术验证与酒精依赖相关的FYN变异的功能效应
Bilal Cakir,Yoshiaki Tanaka,Mu Seog Choe et al.
Bilal Cakir et al.
Alcohol dependence (AD) is one of the most prevalent neuropsychiatric disorders. Multiple polymorphisms in the Fyn tyrosine kinase gene (FYN) were found to be associated with AD. The function of AD-associated FYN variants remains largely un...
Loss of Ubiquitin-Specific Protease 11 Mitigates Pulmonary Fibrosis in Human Pluripotent Stem Cell-Derived Alveolar Organoids [0.03%]
人多能干细胞来源的肺泡类器官中泛素特异性蛋白酶11失活可减轻肺纤维化
Sripriya Rajkumar,Ji-Hye Jung,Ji-Young Kim et al.
Sripriya Rajkumar et al.
The etiology of chronic and lethal interstitial lung disease, termed idiopathic pulmonary fibrosis (IPF), remains unidentified. IPF induces pathological lung scarring that results in rigidity and impairs gas exchange, eventually resulting i...
A Phase 1/2a Clinical Trial to Evaluate the Efficacy and Safety of Allogenic Adipose Tissue-Derived Mesenchymal Stem Cell Clusters in Patients with Critical Limb Ischemia [0.03%]
同种异体脂肪来源间充质干细胞聚集体在肢体缺血患者中有效性和安全性评估的I/IIa期临床试验
Yong-Man Park,Joon-Kee Park,Hyo-Shin Kim et al.
Yong-Man Park et al.
Critical limb ischemia (CLI) is a severe manifestation of peripheral arterial disease, often resulting in ischemic rest pain, non-healing ulcers, or gangrene. Due to the limited effectiveness of conventional revascularization techniques in ...
Effects of Dexamethasone and Tacrolimus on Mesenchymal Stem Cell Characteristics and Gene Expression [0.03%]
地塞米松和他克莫司对间充质干细胞特性及基因表达的影响
Na Kyung Lee,Duk L Na,Su Hyeon Myeong et al.
Na Kyung Lee et al.
Mesenchymal stem cells (MSCs) are frequently used for therapeutic applications in both pre-clinical and clinical settings owing to their capacity for immune modulation and neuroprotective effects. However, transient fever is commonly observ...
Extracellular Vesicles from Induced Mesenchymal Stem Cells Inhibit Acute Kidney Injury to Chronic Kidney Disease Transition [0.03%]
来自诱导间充质干细胞的细胞外囊泡可抑制急性肾损伤向慢性肾病过渡
Hongduk Kim,Sungok Hong,Soo Kim et al.
Hongduk Kim et al.
Compared with conventional mesenchymal stem cells (MSCs), induced mesenchymal stem cells (iMSCs) from induced pluripotent stem cells are unique cell sources for tissue regeneration. The effect of extracellular vesicles (EVs) secreted from i...