Chemically Derived Hepatic Progenitors Are Reprogrammed through Autophagy Suppression by A83-01 [0.03%]
通过自噬抑制A83-01化学诱导肝祖细胞重编程
Hayoon Kim,Seunghee Kim,Soraya Salas-Silva et al.
Hayoon Kim et al.
Human chemically derived hepatic progenitors (hCdHs) reprogrammed using three chemicals-HGF, A83-01, and CHIR99021 (collectively denoted as "HAC")-have been suggested as a novel therapeutic for patients with severe liver diseases in our pre...
Protective Effect of Brain Derived Neurotrophic Factor-Overexpressing Wharton's Jelly-Derived Mesenchymal Stromal Cells in Severe Intraventricular Hemorrhage in Newborn Rats [0.03%]
过表达脑源性神经营养因子的沃顿胶间充质干细胞对新生大鼠重度脑室内出血的保护作用
So Yeon Jung,Misun Yang,Young Eun Kim et al.
So Yeon Jung et al.
The brain-derived neurotrophic factor (BDNF) plays a crucial role in neuroprotection, and we have previously demonstrated BDNF-mediated neuroprotective effects in mesenchymal stromal cells (MSCs). The present study aimed to investigate whet...
Stem Cell R&D in Korea: Yesterday, Today, and Tomorrow - A Paradigm Shift from Therapeutics to Bio-Platforms [0.03%]
韩国的干细胞研发：过去、现在与未来——从治疗到生物平台的范式转变
Moo Woong Kim,Jeong Tae Do,Yun Sil Chang
Moo Woong Kim
Stem Cell-Derived Embryo Models: Potential Platforms for Investigating Early Development and Embryotoxicity [0.03%]
基于干细胞的胚胎模型：研究早期发育和胚胎毒性的潜在平台
Yeji Lee,Jeong Tae Do
Yeji Lee
Stem cell-derived embryo models (SCDEMs) create opportunities to investigate the morphological dynamics and underlying mechanisms of embryonic development, implantation, and post-implantation progression by recapitulating pre-and peri-impla...
Dual Specificity Phosphatase 27 Regulates Pluripotency and Meso-Endodermal Differentiation by Interacting with Transcription Factor CP2 Like-1 in Embryonic Stem Cells [0.03%]
转录因子CP2_like_1的相互作用调控胚胎干细胞的多能性和中内胚层分化
Sujin Song,Jinbeom Heo,Siwon Lee et al.
Sujin Song et al.
Transcription factor CP2-like protein 1 (Tfcp2l1), a naïve pluripotency transcription factor, is expressed in both early embryonic and adult tissues, where it enforces pluripotency of embryonic stem cells (ESCs) and stemness features of ca...
The Generation of an Induced Pluripotent Stem Cell Line from a Patient with Phenylketonuria [0.03%]
苯酮尿症患者的诱导多能干细胞系的建立
Inseon Yu,Heebin Park,Jeongho Lee et al.
Inseon Yu et al.
Phenylketonuria (PKU), an autosomal recessive genetic disorder, has been documented to exhibit over 950 distinct mutations. This condition primarily affects the metabolism of phenylalanine, which is affected by a deficiency in the hepatic e...
Unraveling Optimal Dose and Responsive Markers for Human Cord Blood Derived Mononuclear Cells in Alleviating Bronchopulmonary Dysplasia in Neonatal Mice [0.03%]
人脐带血单个核细胞缓解新生小鼠支气管肺发育不良的最优剂量及反应标志物筛选
Jia Chen,Yuhan Chen,Xue Du et al.
Jia Chen et al.
Bronchopulmonary dysplasia (BPD), characterized by impaired alveolarization and dysregulated vascularization, is a severe health burden for neonates worldwide. Hyperoxia induced acute lung injury is a major contributor to the progression an...
Organoid Technology as a Promising Frontier in Organ Transplantation and Regenerative Medicine [0.03%]
类器官技术：器官移植与再生医学的前沿方向展望
Aeri Shin,Min Kyu Yum,Woong Sun
Aeri Shin
The advent of medical advances has resulted in the development of an array of treatments aimed at restoring damaged organs in humans. However, when chemical treatments, such as drug therapies, are constrained, organ transplantation may ulti...
Hyun Jin Baek,Yoojun Nam,Yeri Alice Rim et al.
Hyun Jin Baek et al.
A rare disease is generally defined as a medical condition that affects a small proportion of the population, though specific thresholds vary across countries. Despite regional differences, these definitions consistently reflect the low pre...
Anti-Obesity Effects of Pear Extract (Pyrus pyrifolia): Clinical Implications and Therapeutic Potential [0.03%]
雪梨提取物的抗肥胖效果：临床意义和治疗潜力
Yong Kyun Roh,Yoon-Su Ha,Taek-Kyong Kim et al.
Yong Kyun Roh et al.
Mitigating obesity is a pivotal strategy for addressing metabolic diseases, including cardiovascular diseases, liver diseases, and diabetes. Although pear extract exhibits various pharmacological effects in regenerative diseases, such as sk...