Dual Specificity Phosphatase 27 Regulates Pluripotency and Meso-Endodermal Differentiation by Interacting with Transcription Factor CP2 Like-1 in Embryonic Stem Cells [0.03%]
转录因子CP2_like_1的相互作用调控胚胎干细胞的多能性和中内胚层分化
Sujin Song,Jinbeom Heo,Siwon Lee et al.
Sujin Song et al.
Transcription factor CP2-like protein 1 (Tfcp2l1), a naïve pluripotency transcription factor, is expressed in both early embryonic and adult tissues, where it enforces pluripotency of embryonic stem cells (ESCs) and stemness features of ca...
The Generation of an Induced Pluripotent Stem Cell Line from a Patient with Phenylketonuria [0.03%]
苯酮尿症患者的诱导多能干细胞系的建立
Inseon Yu,Heebin Park,Jeongho Lee et al.
Inseon Yu et al.
Phenylketonuria (PKU), an autosomal recessive genetic disorder, has been documented to exhibit over 950 distinct mutations. This condition primarily affects the metabolism of phenylalanine, which is affected by a deficiency in the hepatic e...
Unraveling Optimal Dose and Responsive Markers for Human Cord Blood Derived Mononuclear Cells in Alleviating Bronchopulmonary Dysplasia in Neonatal Mice [0.03%]
人脐带血单个核细胞缓解新生小鼠支气管肺发育不良的最优剂量及反应标志物筛选
Jia Chen,Yuhan Chen,Xue Du et al.
Jia Chen et al.
Bronchopulmonary dysplasia (BPD), characterized by impaired alveolarization and dysregulated vascularization, is a severe health burden for neonates worldwide. Hyperoxia induced acute lung injury is a major contributor to the progression an...
Organoid Technology as a Promising Frontier in Organ Transplantation and Regenerative Medicine [0.03%]
类器官技术：器官移植与再生医学的前沿方向展望
Aeri Shin,Min Kyu Yum,Woong Sun
Aeri Shin
The advent of medical advances has resulted in the development of an array of treatments aimed at restoring damaged organs in humans. However, when chemical treatments, such as drug therapies, are constrained, organ transplantation may ulti...
Hyun Jin Baek,Yoojun Nam,Yeri Alice Rim et al.
Hyun Jin Baek et al.
A rare disease is generally defined as a medical condition that affects a small proportion of the population, though specific thresholds vary across countries. Despite regional differences, these definitions consistently reflect the low pre...
Anti-Obesity Effects of Pear Extract (Pyrus pyrifolia): Clinical Implications and Therapeutic Potential [0.03%]
雪梨提取物的抗肥胖效果：临床意义和治疗潜力
Yong Kyun Roh,Yoon-Su Ha,Taek-Kyong Kim et al.
Yong Kyun Roh et al.
Mitigating obesity is a pivotal strategy for addressing metabolic diseases, including cardiovascular diseases, liver diseases, and diabetes. Although pear extract exhibits various pharmacological effects in regenerative diseases, such as sk...
Induced Pluripotent Stem Cells derived CD71＋CD235a＋ Erythroblasts Were Increased by Sirtuin 1 Activator [0.03%]
诱导多能干细胞来源的CD71+CD235a+红系细胞由沉默信息调节因子1激活剂诱导增多
Changyeong Kim,Kyung Hwan Park,Soo-Been Jeon et al.
Changyeong Kim et al.
Induced pluripotent stem cells (iPSCs) are a promising cell source for regenerative medicine. Clinical applications require a large number of functional red blood cells (RBCs), making it essential to ensure the proliferation of actively div...
Kap1 Regulates Protein Stability of Nanog by Interfering with Fbxw8-Dependent Ubiquitination [0.03%]
kap1通过干扰fbxw8依赖性的泛素化调节nanog蛋白稳定性
Hye Ji Moon,Nayeon Lee,Bo Seok Lee et al.
Hye Ji Moon et al.
Nanog is a key transcription factor that regulates the self-renewal and pluripotency of embryonic stem cells (ESCs). Although Kap1 has been demonstrated to regulate the stability of stemness factors, including Oct4 and Lin28A, its role in r...
Beyond Structure: Next-Generation Electrophysiological Platforms for Functional Brain Organoids [0.03%]
超越结构：功能性脑类器官下一代电生理平台
Ji-Hyoung Cha,Keuntae Kim,Il-Joo Cho
Ji-Hyoung Cha
Brain organoids have emerged as transformative models for studying human neurodevelopment, neurological disorders, and personalized therapeutics. Central to their utility is the ability to monitor neural activity with high spatial and tempo...
Recent Applications of Lung Organoid and Lung-on-a-Chip Technologies for Evaluating the Toxicity of Fine Particulate Matter [0.03%]
肺器官体和肺芯片技术在评估细颗粒物毒理学中的最新应用
Minje Kang,Ji-Young Kim,Chan Woo Kwon et al.
Minje Kang et al.
There is mounting epidemiologic and experimental evidence of the harmful effects of exposure to fine particulate matter (PM2.5) on human lung health. However, the current utilization of in vitro two-dimensional (2D) cell culture and in vivo...