Neuroprotective Effects of Transplanted Induced Pluripotent Stem Cell-Derived Neural Precursors in Huntington's Disease Models [0.03%]
诱导多能干细胞来源的神经前体细胞移植在亨廷顿舞蹈病模型中的神经保护作用
Hyeonjoong Jeon,Il-Shin Lee,Dong Gyu Lee et al.
Hyeonjoong Jeon et al.
Huntington's disease (HD) is characterized by progressive striatal degeneration associated with mutant huntingtin (mHTT)-related proteostatic disruption and chronic neuroinflammation. Although mHTT-lowering approaches hold therapeutic promi...
Exploring the Potential of Wharton's Jelly-Derived Mesenchymal Stem Cells as a Therapeutic Approach for Preterm Premature Rupture of Membranes [0.03%]
威坛胶原干细胞作为治疗胎膜早破的潜在疗法研究
Hyeongseop Kim,Hyunju Kim,Suyeon Jeon et al.
Hyeongseop Kim et al.
Preterm premature rupture of membranes (PPROM) is a major cause of preterm birth and neonatal morbidity, with no established treatment to restore membrane integrity. Mesenchymal stem cells (MSCs), known for their regenerative and immunomodu...
Investigating the Causal Links between the Aging Process and Alzheimer's Disease Pathogenesis [0.03%]
探究衰老过程与阿尔茨海默病发病机制之间的因果关系
Jaewoo Seok,Hyein Lee,Jinsoo Seo
Jaewoo Seok
As global societies age, the prevalence of neurodegenerative disorders, such as Alzheimer's disease, is rapidly increasing, intensifying the need to understand the mechanisms of aging and their contribution to these conditions. Consequently...
PRPS1 (p.V42L) Mutation in Arts Syndrome Induces Aberrant Neural Stem Cell Development and Neuronal Senescence-Like Phenotype: Rescue by Nicotinamide Mononucleotide Supplementation [0.03%]
PRPS1(p.V42L)基因突变通过异常的神经干细胞发育和神经元衰老样表型诱导ARTS综合征：烟酸单核苷酸补充对其有治疗作用
Ji-Hee Kim,Su-Jung Park,Jeong-A Lee et al.
Ji-Hee Kim et al.
Arts syndrome is a rare X-linked recessive neurodevelopmental disorder arising from pathogenic variants in PRPS1, which encodes phosphoribosyl pyrophosphate synthetase 1-an enzyme essential for de novo nucleotide biosynthesis. Affected indi...
STOML2 Maintains Pluripotency and Cell Cycle Integrity in Human Pluripotent Stem Cells via PHB-ERK Signaling [0.03%]
STOML2通过PHB-ERK信号通路维持人多能干细胞的多能性和细胞周期完整性
Yena Song,Bomi Kim,Ahyeon Kim et al.
Yena Song et al.
Human pluripotent stem cells (hPSCs) can self-renew indefinitely and differentiate into all three germ layers. However, the primary regulators of hPSC cell cycle dynamics remain unclear. To identify novel regulators of hPSC proliferation, t...
Integrated Electrophysiological and Optical Analysis of Human iPSC-Derived Cardiomyocytes Using Transparent ITO Microelectrode Chip [0.03%]
透明ITO微电极芯片在人诱导多能干细胞源心脏细胞中的电生理和光学综合分析研究
Seul-Gi Lee,Shinhye Park,C-Yoon Kim et al.
Seul-Gi Lee et al.
Cardiotoxicity assessment is a crucial step in the drug development process. With growing interest in alternatives to animal testing, preclinical cardiotoxicity evaluation has become increasingly important. Human-induced pluripotent stem ce...
Evaluation of Pyrene Induced Cardiotoxicity Using Dual-Cardiotoxicity Evaluation Method [0.03%]
应用双重心脏毒性评价方法评价荧蒽诱导的心脏毒性
Hyewon Shin,C-Yoon Kim,Hyung Min Chung et al.
Hyewon Shin et al.
Pyrene (Pyr), a representative subtype of polycyclic aromatic hydrocarbons, is primarily generated during the incomplete combustion of organic matter. As an environmental pollutant, Pyr has been reported to exert adverse effects on various ...
Exosomes from Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells Protect Lung Epithelium and Attenuate Fibrosis [0.03%]
人胚胎干细胞来源的间充质干细胞外泌体对肺上皮具有保护作用并能减轻纤维化
Sangryul Cha,Jooyeon Lee,Jimin Jang et al.
Sangryul Cha et al.
Idiopathic pulmonary fibrosis (IPF) is characterized by maladaptive epithelial-mesenchymal crosstalk and progressive extracellular matrix accumulation, whereas currently available antifibrotic agents merely decelerate functional decline. Th...
hiPSC-Derived M1 Macrophages Exhibit Synergistic Therapeutic Effects with Paclitaxel in Ovarian Cancer [0.03%]
人诱导多能干细胞来源的M1巨噬细胞与紫杉醇在卵巢癌治疗中具有协同效应
Suji Jeong,Seho Cha,Haengseok Song et al.
Suji Jeong et al.
Ovarian cancer remains one of the most lethal gynecologic malignancies, with limited responsiveness to standard chemotherapy and poor long-term prognosis. Tumor-associated macrophages, particularly M2-polarized populations, play a crucial r...
Extracellular Vesicles in Liver Disease: Redefining Diagnostic and Therapeutic Strategies [0.03%]
肝病的细胞外囊泡：重新定义诊断和治疗策略
A-Reum Kim,Minseok Kang,Dong-Young Kim et al.
A-Reum Kim et al.
Extracellular vesicles (EVs) are crucial mediators of intercellular communication, which facilitate the transfer of bioactive molecules such as proteins, lipids, and nucleic acids. Their high biocompatibility and intrinsic targeting abiliti...