STOML2 Maintains Pluripotency and Cell Cycle Integrity in Human Pluripotent Stem Cells via PHB-ERK Signaling [0.03%]
STOML2通过PHB-ERK信号通路维持人多能干细胞的多能性和细胞周期完整性
Yena Song,Bomi Kim,Ahyeon Kim et al.
Yena Song et al.
Human pluripotent stem cells (hPSCs) can self-renew indefinitely and differentiate into all three germ layers. However, the primary regulators of hPSC cell cycle dynamics remain unclear. To identify novel regulators of hPSC proliferation, t...
Integrated Electrophysiological and Optical Analysis of Human iPSC-Derived Cardiomyocytes Using Transparent ITO Microelectrode Chip [0.03%]
透明ITO微电极芯片在人诱导多能干细胞源心脏细胞中的电生理和光学综合分析研究
Seul-Gi Lee,Shinhye Park,C-Yoon Kim et al.
Seul-Gi Lee et al.
Cardiotoxicity assessment is a crucial step in the drug development process. With growing interest in alternatives to animal testing, preclinical cardiotoxicity evaluation has become increasingly important. Human-induced pluripotent stem ce...
Evaluation of Pyrene Induced Cardiotoxicity Using Dual-Cardiotoxicity Evaluation Method [0.03%]
应用双重心脏毒性评价方法评价荧蒽诱导的心脏毒性
Hyewon Shin,C-Yoon Kim,Hyung Min Chung et al.
Hyewon Shin et al.
Pyrene (Pyr), a representative subtype of polycyclic aromatic hydrocarbons, is primarily generated during the incomplete combustion of organic matter. As an environmental pollutant, Pyr has been reported to exert adverse effects on various ...
Exosomes from Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells Protect Lung Epithelium and Attenuate Fibrosis [0.03%]
人胚胎干细胞来源的间充质干细胞外泌体对肺上皮具有保护作用并能减轻纤维化
Sangryul Cha,Jooyeon Lee,Jimin Jang et al.
Sangryul Cha et al.
Idiopathic pulmonary fibrosis (IPF) is characterized by maladaptive epithelial-mesenchymal crosstalk and progressive extracellular matrix accumulation, whereas currently available antifibrotic agents merely decelerate functional decline. Th...
hiPSC-Derived M1 Macrophages Exhibit Synergistic Therapeutic Effects with Paclitaxel in Ovarian Cancer [0.03%]
人诱导多能干细胞来源的M1巨噬细胞与紫杉醇在卵巢癌治疗中具有协同效应
Suji Jeong,Seho Cha,Haengseok Song et al.
Suji Jeong et al.
Ovarian cancer remains one of the most lethal gynecologic malignancies, with limited responsiveness to standard chemotherapy and poor long-term prognosis. Tumor-associated macrophages, particularly M2-polarized populations, play a crucial r...
Extracellular Vesicles in Liver Disease: Redefining Diagnostic and Therapeutic Strategies [0.03%]
肝病的细胞外囊泡：重新定义诊断和治疗策略
A-Reum Kim,Minseok Kang,Dong-Young Kim et al.
A-Reum Kim et al.
Extracellular vesicles (EVs) are crucial mediators of intercellular communication, which facilitate the transfer of bioactive molecules such as proteins, lipids, and nucleic acids. Their high biocompatibility and intrinsic targeting abiliti...
Chemically Derived Hepatic Progenitors Are Reprogrammed through Autophagy Suppression by A83-01 [0.03%]
通过自噬抑制A83-01化学诱导肝祖细胞重编程
Hayoon Kim,Seunghee Kim,Soraya Salas-Silva et al.
Hayoon Kim et al.
Human chemically derived hepatic progenitors (hCdHs) reprogrammed using three chemicals-HGF, A83-01, and CHIR99021 (collectively denoted as "HAC")-have been suggested as a novel therapeutic for patients with severe liver diseases in our pre...
Protective Effect of Brain Derived Neurotrophic Factor-Overexpressing Wharton's Jelly-Derived Mesenchymal Stromal Cells in Severe Intraventricular Hemorrhage in Newborn Rats [0.03%]
过表达脑源性神经营养因子的沃顿胶间充质干细胞对新生大鼠重度脑室内出血的保护作用
So Yeon Jung,Misun Yang,Young Eun Kim et al.
So Yeon Jung et al.
The brain-derived neurotrophic factor (BDNF) plays a crucial role in neuroprotection, and we have previously demonstrated BDNF-mediated neuroprotective effects in mesenchymal stromal cells (MSCs). The present study aimed to investigate whet...
Stem Cell R&D in Korea: Yesterday, Today, and Tomorrow - A Paradigm Shift from Therapeutics to Bio-Platforms [0.03%]
韩国的干细胞研发：过去、现在与未来——从治疗到生物平台的范式转变
Moo Woong Kim,Jeong Tae Do,Yun Sil Chang
Moo Woong Kim
Stem Cell-Derived Embryo Models: Potential Platforms for Investigating Early Development and Embryotoxicity [0.03%]
基于干细胞的胚胎模型：研究早期发育和胚胎毒性的潜在平台
Yeji Lee,Jeong Tae Do
Yeji Lee
Stem cell-derived embryo models (SCDEMs) create opportunities to investigate the morphological dynamics and underlying mechanisms of embryonic development, implantation, and post-implantation progression by recapitulating pre-and peri-impla...