Generation of a Patient-Derived Inducible Pluripotent Stem Cell Model for Studying the YARS2-Related Genetic Disease [0.03%]
用于研究YARS2相关遗传病的诱导多能干细胞系的建立
Chenbo Zeng,Andrew Gray,Rebecca Ganetzky et al.
Chenbo Zeng et al.
The YARS2 variant, harboring the compound heterozygous pathogenic mutations F185L/E264del, was identified in the gene for mitochondrial tyrosyl-tRNA synthetase in a proband that suffered a neonatal phenotype. To facilitate studies to better...
A Preliminary Study on Evaluating Reparative Regeneration Potential of Human Amniotic Fluid Stem Cells Spheres in Stress Urinary Incontinence Rats [0.03%]
人羊水干细胞球对压力性尿失禁修复再生潜能的初步研究
Shing-Hwa Lu,Shiaw-Min Hwang,Navneet Kumar Dubey et al.
Shing-Hwa Lu et al.
Recent reports indicate that stem cell spheres might offer enhanced therapeutic benefits by promoting cell engraftment ability, stemness, angiogenesis, and chemotaxis. Hence, we investigated whether amniotic fluid stem cells (AFSC) spheres ...
Adipose-Derived Mesenchymal Stem Cells Improve Motor Function and Reduce Neuroinflammation and Mutant Ataxin-3 Protein Levels in SCA3 Mice [0.03%]
脂肪来源的间充质干细胞可改善SCA3小鼠的运动功能并减少神经炎症和突变ataxin-3蛋白水平
Kuan-Ming Lu,Wei-Kee Ong,ChingHuai Ko et al.
Kuan-Ming Lu et al.
The CAG expansion in the ataxin-3 (ATXN3) protein is the underlying cause of Spinocerebellar Ataxia Type 3 (SCA3), a polyglutamine disease. The aggregation of mutant ATXN3 protein is hypothesized to contribute to neuronal dysfunction, neuro...
Byungkuk Min,Juhyeon Nam,Minseo Choi et al.
Byungkuk Min et al.
Partial reprogramming with Yamanaka factors effectively reverses cellular aging but poses potential oncogenic risks, limiting clinical translation. To identify safer rejuvenation induction factors (RIFs), we integrated five aging datasets a...
Altered Properties of Bone Marrow-Derived Mesenchymal Stem Cells Exposed to Serum from Patients with Acute-On-Chronic Liver Failure [0.03%]
慢性急性肝功能衰竭患者血清暴露对骨髓间充质干细胞的影响
Wenxin Zhang,Shurong Liu,Zhiru Wang et al.
Wenxin Zhang et al.
Acute-on-chronic liver failure (ACLF) is a high-mortality syndrome characterized by acute decompensation of liver function. Oxidative stress exerts a pivotal regulatory role in ACLF. Mesenchymal stem cell (MSC)-based therapy is a promising ...
Retraction Notice to: Improvement of Human Sperm Vacuolization and DNA Fragmentation Co-Cultured with Adipose-Derived Mesenchymal Stem Cell Secretome: In Vitro Effect [0.03%]
撤稿通知：改善人源精子 vacuum和DNA片段与脂肪来源间充质干细胞分泌组共培养的体外效应
Robert Bader,José-Noel Ibrahim,Ali Mourad et al.
Robert Bader et al.
Targeting Oxidative Stress during the Post-Thawing Recovery Window Improves Cryopreservation Outcomes in Human Neural Organoids [0.03%]
冻融后 targeting 氧化应激可改善人神经器官体的 cryopreservation 结果
Yejin Kwon,Aeri Shin,Garam Kim et al.
Yejin Kwon et al.
Neural organoids serve as critical in vitro models for recapitulating the structural and functional complexities of the human nervous system. However, the transition toward high-throughput drug screening and industrial-scale applications is...
Multiscale Convergence of Signaling, Epigenetic, and Environmental Networks in Mammalian Palatogenesis and Cleft Palate Pathogenesis [0.03%]
哺乳动物腭发育和腭裂发生过程中信号通路、表观遗传及环境网络的多尺度汇聚模式研究进展
Hyung-Jin Won,Beomjong Song,Yujeong Song et al.
Hyung-Jin Won et al.
Palatogenesis is tightly regulated at cellular and molecular levels. Cranial neural crest cells (CNCCs), multipotent stem cells that generate most palatal mesenchyme, self-renew, decide fate, and differentiate under cues from their stem cel...
Sang Hyeon Woo,Sehyun Chae,Byung-Ho Rhie et al.
Sang Hyeon Woo et al.
Long-term culture of human pluripotent stem cells (hPSCs) can lead to spontaneous mutations, genomic abnormalities, and alterations in gene expression, thereby compromising their self-renewal and pluripotency. Thus, optimizing the long-term...
Stem Cell-Based Regeneration of Atrophied Vocal Folds after Recurrent Laryngeal Nerve Injury [0.03%]
喉返神经损伤后声带萎缩的干细胞再生疗法
Min Ji Lee,Se-Young Oh,Soo Yeon Jung et al.
Min Ji Lee et al.
This study evaluated the therapeutic potential of calcium hydroxylapatite (CaHA) and tonsil-derived mesenchymal stem cells (TMSCs) suspended in hyaluronic acid (HA) for regenerating atrophied vocal fold in a rabbit model of recurrent laryng...