Leveraging Quantitative Proteomics and Extracellular Vesicle Data to Uncover Druggable Receptor Kinases Across Cancers [0.03%]
利用定量蛋白质组学和细胞外囊泡数据揭示癌症中的可药物靶点受体激酶
Jina Kim,Su Yeon Yeon,Kyerim Choi et al.
Jina Kim et al.
Extracellular vesicles (EVs) play an important role in cancer progression and metastasis. The increasing clinical proteomics data provides an opportunity to uncover new biomarkers and therapeutic targets in cancer specific EVs. Here, we pre...
Proteomic Profiling of Human Extracellular Vesicles Reveals Diagnostic Biomarkers for Colon Adenocarcinoma [0.03%]
人类细胞外囊泡的蛋白质组学分析发现结肠腺癌诊断标志物
Yura Seo,Yoon Dae Han,Linda Bojmar et al.
Yura Seo et al.
Early detection of colon adenocarcinoma (COAD) remains suboptimal. Fecal tests fail to diagnose 30% of stage I cancer, and serum CEA lacks sensitivity (< 40%). Extracellular vesicles (EVs) circulate systemically and package tumor-related ca...
PREDICTOR: A Non-Enzymatic Catalytic Cascade Tool for in Situ Visualization of Small Extracellular Vesicle Surface glycoRNAs [0.03%]
预测器：一种用于现场可视化小型细胞外囊泡表面糖基RNA的非酶催化级联工具
Shuang Xie,Ben Niu,Ruijia Deng et al.
Shuang Xie et al.
Glycosylated RNAs (glycoRNAs) are membrane-displayed RNA-glycan conjugates, but quantitative in situ analysis of low-abundance glycoRNAs on small extracellular vesicles (sEVs) remains challenging. Here, we develop PREDICTOR (proximity-encod...
Nano-Flow Cytometry of Single Extracellular Vesicles Reveals Subpopulation Differences Across Cell Types and Pharmacological Perturbations [0.03%]
单个细胞外囊泡的纳米流式检测揭示不同细胞类型和药理学干扰下的亚群差异
Nathalie Nevo,Alix Zhou,Nicolas Ansart et al.
Nathalie Nevo et al.
Extracellular vesicles (EVs) are lipid bilayer-enclosed particles released by most cell types, which can transfer signals and cargoes between cells. EVs released by a single donor cell source are increasingly recognised as extremely heterog...
Systemic Inflammation Modulates Clearance and Drives Extra-Hepatic Distribution of Extracellular Vesicles [0.03%]
全身性炎症调节外泌体的清除并促使其发生肝外分布
Svetlana Pavlova,Doste R Mamand,André Görgens et al.
Svetlana Pavlova et al.
Extracellular vesicles (EVs) are promising vehicles for targeted therapeutic delivery, capable of encapsulating and transporting biomolecules to specific cells and tissues. Given that inflammation is central to many acute and chronic diseas...
Chemoradiotherapy-Integrated Tumor Cell-Derived Microparticles Mediate Tumor Eradication in Malignant Pleural Effusion [0.03%]
化疗联合放射治疗肿瘤细胞源性微颗粒介导恶性胸腔积液的根除作用
Minqi Zhou,Lingyi Kong,Weidong Zhong et al.
Minqi Zhou et al.
Malignant pleural effusion (MPE) portends poor prognosis in advanced cancer. Strategies that integrate potent tumor killing with immunosuppressive microenvironment reprogramming are crucial for the treatment of MPE. Studies show that irradi...
Cisplatin Promotes Immunosuppression in Ovarian Cancer by Enhancing miR-181a-5p-Enriched Extracellular Vesicles to Drive Regulatory T Cell Differentiation [0.03%]
顺铂通过增强富含miR-181a-5p的细胞外囊泡促进卵巢癌免疫抑制并驱动调节性T细胞分化
Liyan Zheng,Sijia Mu,Mingxue Liu et al.
Liyan Zheng et al.
Although cisplatin (CDDP) is widely employed in combination immunotherapy, no CDDP-based regimen has shown a survival benefit when treating the ovarian cancers. This is mainly because the impact of CDDP on immunotherapy is not fully underst...
Distinguishing Pseudotransduction and True Transduction Enables Characterization and Bioengineering of Extracellular Vesicle-Adeno-Associated Virus Vectors [0.03%]
伪转导和真转导的区别使得能够表征和工程化细胞外囊泡-腺相关病毒载体
Jonathan D Boucher,Devin M Stranford,Hailey I Edelstein et al.
Jonathan D Boucher et al.
Adeno-associated virus (AAV) gene therapies have achieved some clinical success, with multiple products reaching regulatory approval. Encapsulation of AAV vectors within engineered extracellular vesicles (EVs) is an emerging strategy which ...
An Engineered Nano-Vesicle Adjuvant Platform (ENAP) for Cytokine Delivery Enables a Novel Antigen-Coordinated Vaccine Against Helicobacter pylori [0.03%]
一种工程化的纳米囊泡佐剂平台（ENAP），用于细胞因子输送，以实现新的抗原协同疫苗来对抗幽门螺旋杆菌
Yinpan Shang,Xiran Zhang,Linwei Li et al.
Yinpan Shang et al.
Despite the considerable potential of Helicobacter pylori (H. pylori) vaccines, their clinical efficacy has been hampered by inadequate mucosal immunity and suboptimal Th1/Th17 polarization. To address this, we engineered a novel nano-adjuv...