When Viruses Talk through Extracellular Vesicles: a New Perspective on Sars-Cov-2-Induced Neurodegeneration [0.03%]
病毒通过细胞外囊泡交流：关于SARS-CoV-2诱导神经退行性病变的新视角
Gunjan Bawne,Loet Coenen,Erik Nutma et al.
Gunjan Bawne et al.
SARS-CoV-2 infection is linked to persistent neurological symptoms Post-Acute Sequelae SARS-CoV-2 (neuro-PASC) and elevated risk of neurodegenerative disease, but molecular events connecting acute viral injury to long-term CNS dysfunction r...
Outer Membrane Vesicles Mediate the Secretion and Nuclear Trafficking of a Bacterial Nucleomodulin [0.03%]
外膜囊泡介导细菌核调节素的分泌及胞核运输
Jack K Emery,Variya Nemidkanam,Nina Colon et al.
Jack K Emery et al.
Nucleomodulins are a family of bacterial virulence proteins that traffic to the nucleus of host cells to disrupt nuclear processes and, in some cases, promote carcinogenesis. The mechanisms by which nucleomodulins are secreted and injected ...
Development of CAR Exosomes Targeting FAP for the Treatment of Intrauterine Adhesion [0.03%]
靶向FAP的CAR外泌体治疗宫腔粘连研究进展
Wenyan Fu,Kewen Qian,Hongru Ai et al.
Wenyan Fu et al.
Engineered extracellular vesicles (EVs) have emerged as promising cell-free platforms for immunomodulation and tissue repair. In this study, we generated EVs derived from chimeric antigen receptor (CAR) T cells targeting fibroblast activati...
Lipidome Analysis of Cancer Cells and Their Extracellular Vesicles Reveals Cancer-Type-Specific Lipid Signatures and Enables the Design of EV-Mimetic Liposomes [0.03%]
癌细胞及其细胞外囊泡的脂质组分析揭示了癌症特异性脂质特征并可设计EV类似物脂质体
Noélie Douanne,Yousra Benslimane,Rubén R López et al.
Noélie Douanne et al.
Lipid metabolism reprogramming is a hallmark of cancer, yet the global lipidome of cancer cells and their extracellular vesicles (EVs) remains poorly understood. Using mass spectrometry, we analyzed the lipid profiles of a panel of human ca...
Yersinia enterocolitica O:3 Outer Membrane Vesicles as a Platform for Complement Activation [0.03%]
耶尔森菌O:3型外膜囊泡活化补体的作用机制研究
Cédric Battaglino,Iryna Bodnaruk,Paula Czyszczoń et al.
Cédric Battaglino et al.
Lipopolysaccharide (LPS) is the major component of the outer membrane vesicles (OMVs) of Gram-negative bacteria. We hypothesized that OMVs-induced complement activation contributes to the development of systemic inflammatory response syndro...
Magnetic-Assisted Aptamer Selection and Isolation of Migrasomes for Application in Lung Adenocarcinoma Proteomic Analysis [0.03%]
磁盘辅助aptamer选择和分离迁移体在肺腺癌蛋白质组分析中的应用
Yixin Xu,Lin Jiao,Qiangying Yi et al.
Yixin Xu et al.
Migrasomes, newly discovered vesicular organelles, hold promise as diagnostic biomarkers and therapeutic targets in various diseases. However, the exploration of their clinical value remains hindered by the complexity of enriching and analy...
Transcatheter Intra-Arterial Delivery of a Platelet-Derived Extracellular Vesicle-Enriched Preparation for Attenuating Skeletal Muscle Ischaemia-Reperfusion Injury in a Rodent Forelimb Model [0.03%]
经导管宫内动脉递送血小板源性外泌体富集制剂减轻啮齿动物前肢模型肌肉缺血再灌注损伤
Omar A Selim,Aida Sarcon,Atta Behfar et al.
Omar A Selim et al.
Extracellular vesicles (EVs) are non-replicating, lipid membrane-bound nanoparticles released by most eukaryotic cells into the extracellular space. When derived from platelets, a subset of EVs can exhibit remarkable anti-inflammatory and a...
In-Solution Characterization of Extracellular Vesicles: A New Approach to Evaluating Antibody Binding and Surface Interactions [0.03%]
溶液中鉴定细胞外囊泡的新方法及评估抗体结合和表面相互作用的新方法
Maria-Anthi Kakavoulia,Peter Spies,Tanja J Kutzner et al.
Maria-Anthi Kakavoulia et al.
Extracellular vesicles (EVs) are emerging as diagnostic and therapeutic agents, yet their nanoscale size limits quantitative single-vesicle analysis of surface epitopes and molecular interactions. Flow-Induced Dispersion Analysis (FIDA) is ...
VAMP4/STX8 Mediate the Autophagic Secretion of Mitochondria and Promote TAMs Polarization in HNSCC [0.03%]
VAMP4/STX8介导的线粒体自噬分泌及对头颈鳞癌肿瘤相关巨噬细胞极化的促进作用
Jingcun Shi,Chun Liu,Xiaoning Wang et al.
Jingcun Shi et al.
Under hypoxic conditions, tumour cells engage in autophagic secretion of mitochondria to sustain energy balance and modulate the tumour microenvironment. However, the exact molecular mechanisms remain unclear. This study used a combination ...
Automated Cryo-EM and Supervised Machine Learning Enable Reproducible Characterization of Extracellular Vesicles and Co-Isolating Particles [0.03%]
自动化 cryo-EM 和监督机器学习能够使 extracellular vesicle 的特征描述具有可重复性和 co-isolating 粒子的特征描述
Agustin Enciso-Martinez,Frank G A Faas,Anja W M de Jong et al.
Agustin Enciso-Martinez et al.
Cryo-electron microscopy (cryo-EM) is the only technique capable of visualizing the lipid bilayer of extracellular vesicles (EVs), enabling their distinction from non-EV particles. However, the application of cryo-EM for EV sample character...