In Situ Engineered "Cascade-Amplified" Drug-Loaded Vesicles for Enhanced Cancer Stem Cell Therapy [0.03%]
用于增强癌症干细胞治疗的原位工程化“级联放大”载药囊泡
Tiantian Zhang,YuanYuan Wei,Zimai Liu et al.
Tiantian Zhang et al.
Cancer stem cells (CSCs) characterized by the capacity of self-renewal and drug resistance, are a major cause of tumour recurrence and metastasis. However, CSCs are mainly localized in the deep and hypoxic regions of the tumour microenviron...
Diagnostic and Therapeutic Roles of Extracellular Vesicles in Chronic Kidney Disease: A Systematic Review [0.03%]
外泌体在慢性肾脏病诊断和治疗中的作用：系统性综述
Tunahan Ergunay,Alessia Brossa,Benedetta Bussolati
Tunahan Ergunay
Extracellular vesicles (EVs) are increasingly investigated across a wide range of diseases as potential biomarkers and therapeutic tools. To date, EVs have been isolated from diverse sources, including urine, blood, saliva, tissue, and cell...
Systemic Propagation of STING Signalling via Generation of Large Extracellular Vesicles [0.03%]
通过产生大型细胞外囊泡进行STING信号的系统传播
Jiae Lee,Annabel Vernon,Hyung Joon Park et al.
Jiae Lee et al.
Large extracellular vesicles (EVs) derived from tumour cells play important roles in tumour formation and progression. However, it remains unclear why malignant cells produce these EVs and how they act in vivo. We employ a well-characterize...
The Small Molecule H89 Facilitates Mesenchymal Stem Cell-derived Extracellular Vesicle Release and Optimizes Therapeutic Efficacy in Liver Regeneration [0.03%]
小分子H89促进间充质干细胞源性外泌体释放及肝再生治疗效应研究
Yu Fu,Yi Ma,Jiajun Zhang et al.
Yu Fu et al.
The role of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hUCMSC-EVs) in liver regeneration is promising, yet their clinical translation is hampered by insufficient production. Current strategies targeting their...
Host Factor Induced Bacterial Extracellular Vesicles Promote Horizontal Gene Transfer in Vibrio cholerae [0.03%]
霍乱弧菌感应宿主因子诱导的细菌胞外囊泡促进基因水平转移
Dominik Fleischhacker,Yi-Chi Chen,Noa Sanchez Gordo et al.
Dominik Fleischhacker et al.
Like other Gram-negative bacteria, Vibrio cholerae, releases bacterial extracellular vesicles (BEVs), which have documented roles along the facultative human-pathogen's lifecycle. Most studies have focused on BEVs released its outermost sur...
Quality Evaluation Considerations for Stem Cell-Derived Extracellular Vesicles-Based Therapeutic Products in China [0.03%]
我国诱导多能干细胞来源外泌体质量评价的考虑因素
Tao Na,Kehua Zhang,Libo Zhao et al.
Tao Na et al.
Stem cell therapy is currently undergoing clinical research in China for conditions that are resistant to or incurable by traditional pharmaceutical interventions. Stem cell-derived extracellular vesicles (EVs) exhibit therapeutic effects s...
GCC2 in Small Extracellular Vesicles as a Diagnostic and Prognostic Biomarker of Early-Stage Lung Adenocarcinoma [0.03%]
早诊肺腺癌的新型小细胞外囊泡标记物GCC2
Byeong Hyeon Choi,Hyonggin An,Sukki Cho et al.
Byeong Hyeon Choi et al.
Emerging evidence suggests that GRIP and coiled-coil domain-containing two enriched small extracellular vesicles (sEV-GCC2) may serve as diagnostic biomarkers of early-stage lung adenocarcinomas. However, the roles of these molecules remain...
Multicenter Study
Journal of extracellular vesicles. 2026 May;15(5):e70264. DOI:10.1002/jev2.70264 2026
No Dye Fits All: Illuminating the Challenges of Fluorescent Extracellular Vesicle Labeling [0.03%]
没有一种染料适用所有人：荧光细胞外囊泡标记的挑战
Petra Vrdoljak,Alessandro Idrovo-Gavilanes,Thu Huyen Nguyen et al.
Petra Vrdoljak et al.
The widespread use of fluorescent dyes for extracellular vesicle (EV) labeling has substantially improved our ability to trace EVs in vitro, ex vivo, and in vivo. However, interpretability of these experiments remains limited by methodologi...
RVG-Modified BMSCs-Derived Small Extracellular Vesicles Loaded With miR-21 Alleviate Neuronal Injury Resulted From Excessive Autophagy via Targeting PTEN/Akt/mTOR Pathway After Cerebral Ischaemia [0.03%]
载有miR-21的RVG修饰的BMSC来源的小细胞外囊泡通过靶向PTEN/Akt/mTOR途径减轻脑缺血后过度自噬引起的神经元损伤
Yiyang Li,Jiacheng Hu,Jinfen Chen et al.
Yiyang Li et al.
Ischaemic stroke (IS) leads to tragic disability and high adult mortality, while there are limited therapeutic measures for it. Small extracellular vesicles (sEVs) derived from bone marrow mesenchymal stem cells (BMSCs) have been suggested ...
The Eubacterium Rectale Derived Extracellular Vesicles Alleviate Cancer Cachexia Induced Lipolysis by Inhibiting Macrophage Polarization [0.03%]
肠球菌来源的外泌体通过抑制巨噬细胞极化缓解癌症恶病质引起的脂解作用
Jiaqi Wang,Gulisudumu Maitiabula,Sirui Liu et al.
Jiaqi Wang et al.
Cancer cachexia (CC) is a complex pathological condition associated with cancer progression and poor prognosis, particularly in gastrointestinal cancers, and is closely linked to the gut microbiota. Lipolysis in CC may play a key role in dr...