Metabolic Tagging of Tumour Extracellular Vesicles for Targeted Modulation of Dendritic Cells [0.03%]
代谢标记肿瘤细胞外囊泡以靶向调节树突状细胞
Rimsha Bhatta,Wenhao Xu,Ruike Dai et al.
Rimsha Bhatta et al.
Extracellular vesicles (EVs) have emerged as a promising alternative to cell-based therapies due to their benign safety profiles and favourable pharmacokinetic properties. Tumour EVs, in particular, have shown promise to function as a thera...
Impact of Isolation Techniques on the Content of Small Extracellular Vesicles [0.03%]
分离技术对小型细胞外囊泡含量的影响
Yue Su,Kekoolani S Visan,Sarah Voss et al.
Yue Su et al.
An important topic of discussion amongst the extracellular vesicle (EV) research field is which genetic materials are considered true constituents of EV cargo. What were once regarded as non-EV components have now evolved to be potentially ...
CD133 Shapes Extracellular Vesicle Cargo and Angiogenic Function in Basal-Like Triple-Negative Breast Cancer [0.03%]
CD133塑造基底样三阴性乳腺癌的外泌体内容物和促血管生成功能
Mireia Gomez-Duro,Ptissam Bergam,Sara Sanchez-Redondo et al.
Mireia Gomez-Duro et al.
Extracellular vesicles (EVs) are central mediators of tumour-stroma communication, yet the mechanisms governing their biogenesis and functional cargo remain poorly understood. Here, we identify CD133 (Prominin-1), selectively expressed in b...
Extracellular Vesicles as Enabling Biomarkers for New Approach Methodologies to Support the US Food and Drug Administration Modernization Act 3.0 [0.03%]
外泌体作为支持美国食品和药物管理局现代化法案3.0的新方法的使能生物标志物
Andrew Rowland,Carl Kirkpatrick,A David Rodrigues et al.
Andrew Rowland et al.
The FDA Modernization Act 3.0 represents a pivotal shift in biomedical research by formally removing the requirement for animal testing and enabling regulatory acceptance of New Approach Methodologies (NAMs). This transition creates an urge...
DAMP Laden Extracellular Vesicles From the Airways of Patients With Severe SARS-CoV-2 Respiratory Infection Compromise Inflammation and Cellular Metabolism [0.03%]
来自严重SARS-CoV-2呼吸道感染患者的气道液化渗出细胞外囊泡会损害炎症和细胞代谢
April Rees,Oliver Richards,Molly E Raikes et al.
April Rees et al.
Highly inflammatory mononuclear phagocytes (MNPs) cause tissue damage across the respiratory tract and other organs in response to infections such as SARS-CoV-2. Extracellular vesicles (EVs) can metabolically and phenotypically reprogram ta...
Targeted Delivery of GLUT1 Inhibitor via Macrophage Nanovesicles for Pulmonary Arterial Hypertension Therapy [0.03%]
靶向递送GLUT1抑制剂的巨噬纳米囊泡用于肺动脉高压治疗
Yanzi Guo,Shan Lu,Wenting Wang et al.
Yanzi Guo et al.
Pulmonary arterial hypertension (PAH) is a lethal disease characterized by inflammation-driven vascular remodelling, with a lack of precise intervention strategies targeting pro-inflammatory M1 macrophages' glycolytic metabolic reprogrammin...
DNA Copy Number Profiling in Extracellular Vesicles as Clinical Biomarkers of High-Grade Serous Ovarian Carcinoma [0.03%]
用于高分级浆液性卵巢癌的临床生物标志物的细胞外囊泡中的DNA拷贝数谱分析
Ryosuke Uekusa,Akira Yokoi,Mayu Ukai et al.
Ryosuke Uekusa et al.
Extracellular vesicles (EVs), including exosomes, circulate in body fluids and carry pathological genomic information. High-grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer, characterized predominantly by ...
Current Perspective on Human Milk Derived Vesicles and Their Potential Therapeutic Use: A Scoping Review [0.03%]
人类乳汁衍生囊泡及其潜在治疗应用的综述研究视角
Patricia Hrasnova,Cristian-Tudor Matea,Petra Gombos et al.
Patricia Hrasnova et al.
Human milk-derived extracellular vesicles (HMEVs) recently gained significant attention due to their role in mother-child communication and biomedical application potential. We here provide a systematic scoping review together with interact...
Role of Collection Media on the Biological Activity of Extracellular Vesicles From hTERT-Immortalised Mesenchymal Stromal Cells [0.03%]
收集介质对hTERT永生化间充质基质细胞来源的外泌体生物学活性的影响
Alessia Brancolini,Madhusudhan Reddy Bobbili,Matthias Wieser et al.
Alessia Brancolini et al.
Extracellular Vesicles (EVs) from Mesenchymal Stromal Cells (MSCs) are promising cell-free therapeutics due to their ability to modulate immune responses, promote tissue repair and replicate many benefits of their parental cells. However, d...
Bacterial Extracellular Vesicles: New Hype or Hope to Explain Reproductive Host-Microbiota Interactions [0.03%]
细菌外泌体：阐明生殖宿主-微生态相互作用的新噱头还是希望？
Hannah Wein,Paula Iglesias-Moreno,Apostol Apostolov et al.
Hannah Wein et al.
Rapid advances in microbiome research are transforming our understanding of human health and disease, with growing focus on the female reproductive tract as a critical but understudied niche. Evidence for a local microbiome largely derives ...