Molecular Profiling of Extracellular Vesicles Isolated from Boar Reproductive Fluids [0.03%]
公猪生殖液体外囊泡的分子特征分析
Veronika Kraus,Barbora Doleckova,Michaela Frolikova et al.
Veronika Kraus et al.
Extracellular vesicles (EVs) are small membrane-bound structures that facilitate intercellular communication in the reproductive system, modulating gamete maturation, capacitation, immunomodulation and fertilization. Despite pigs' high rele...
Silencing the Signal: The Metastasis Suppressor NDRG1 Disrupts Small Extracellular Vesicle-Mediated Crosstalk in Pancreatic Cancer [0.03%]
沉默信号：转移抑制因子NDRG1干扰胰腺癌来源的小细胞外囊泡介导的通讯
Jiawei Chang,Shafi Alenizi,Heloisa Zaccaron Milioli et al.
Jiawei Chang et al.
Pancreatic cancer (PaC) remains one of the deadliest cancers, with 5-year survival rates of 13%. A major driver of its aggressiveness is the tumour microenvironment (TME), which fuels tumour growth, metastasis, and therapeutic resistance th...
Integrating Nuclear Magnetic Resonance into Bioprocess Control of Clinical-Grade Extracellular Vesicle Manufacturing [0.03%]
核磁共振在临床级细胞外囊泡生产生物过程控制中的应用整合
Santiago Roura,Núria Amigó,Joaquim Vives
Santiago Roura
The rapid advance in the research and development of extracellular vesicle (EV)-based therapeutics has stimulated a paradigm shift in the field of regenerative medicine. However, translating EV-based therapies into the clinic requires robus...
Eliminating PD-L1 on Dendritic Cell Extracellular Vesicles for Immunotherapy Potentiates Immune-Mediated Tumour Rejection in Mice [0.03%]
消除树突状细胞外泌体上的PD-L1可增强小鼠免疫疗法介导的肿瘤排斥反应
Loes Teeuwen,Loïc Steiner,Chantal Reinhardt et al.
Loes Teeuwen et al.
Extracellular vesicles (EVs) are emerging as promising vehicles for cancer immunotherapy, yet the molecular determinants of their immunogenicity remain poorly defined. While PD-L1 expression on cancer-derived EVs has been shown to suppress ...
Regulatory Challenges and Opportunities for Cell-Derived Extracellular Vesicles in Pharmaceutical Development: A European and Global Perspective [0.03%]
从欧洲和全球视角看细胞来源的外泌体在药物开发中的监管挑战与机遇
Tania Limongi,Paola Milla,Barbara Stella et al.
Tania Limongi et al.
Cell-derived extracellular vesicles (EVs) attract growing interest as biologically active, acellular platforms for therapeutic and diagnostic use in regenerative medicine, immunomodulation, and drug delivery. While EV-based products advance...
Label-Free Clustering Analysis Platform Drives Cascaded Workflow for Scalable Production of Therapeutic Extracellular Vesicles [0.03%]
无标签聚类分析平台驱动的治疗性细胞外囊泡级联生产工艺流程
Jing Zhou,Ping Chen,Xin Chen et al.
Jing Zhou et al.
Extracellular vesicles (EVs) have emerged as highly promising natural nanomedicines and nanocarriers, holding transformative potential for the treatment of various diseases. However, the lack of rapid and comprehensive characterization tech...
Development of Potency Assays for Therapeutic EVs: The Art of Congruence [0.03%]
治疗性外泌体效力测定的发展：一致性之艺
Mario Gimona,Marca H M Wauben,Sun Young Lee et al.
Mario Gimona et al.
Extracellular Vesicles Released by Picornavirus-Infected Cells Modify Antiviral Immune Cell Responses [0.03%]
肠道病毒释放的细胞外囊泡可调节免疫细胞的抗病毒反应
Xinyi Pei,Janine T A T Stienstra,Margarida Viola et al.
Xinyi Pei et al.
Naked viruses of the family Picornaviridae commonly spread via lysis of infected cells. Recent studies indicate that, prior to cell lysis, naked viruses are packaged and released inside extracellular vesicles (EVs). This has been considered...
Endothelial Integrin-Linked Kinase (ILK) Deficiency Promotes Endothelial Activation and Cardiovascular Dysfunction via Receptor Interacting Protein Kinase-1 (RIPK1) Enriched-Extracellular Vesicle Signalling [0.03%]
内皮整合素连接激酶(ILK)缺陷通过受体交互蛋白激酶-1(RIPK1)富集的细胞外囊泡信号转导促进内皮激活和心血管功能障碍
Alberto Cook-Calvete,María Delgado-Marín,Sara Jorquera Ortega et al.
Alberto Cook-Calvete et al.
Integrin-linked kinase (ILK) maintains endothelial homeostasis by supporting endothelial nitric oxide synthase activity and restraining vascular inflammation. Although endothelial ILK loss is linked to vascular and cardiac disease, the mech...