Development of Anti-Inflammatory Extracellular Vesicles by Surface Expression of Syndecan-4 [0.03%]
通过细胞外囊泡表面表达 syndecan-4 开发抗炎型细胞外囊泡
Lijuan Yu,Markus Bergqvist,Kyong-Su Park et al.
Lijuan Yu et al.
The biological functions of extracellular vesicles (EVs) depend on their cellular source. Further, different subpopulations of EVs from the same cells carry different cargo, but differences in their biological functions are less understood....
Extracellular Vesicle-Mediated Nucleolin Transfer in Glioblastoma: A Targetable Axis Driving Blood-Tumour Barrier Formation [0.03%]
胶质母细胞瘤中外泌体介导的核仁蛋白转移：驱动血肿屏障形成的靶向轴
Hongzhen Chen,Junyi Zhao,Fang Qiu et al.
Hongzhen Chen et al.
Glioblastoma (GBM) remains a significant therapeutic challenge. While GBM-derived extracellular vesicles (EVs) are known to remodel the normal blood-brain barrier (BBB) into a blood-tumour barrier (BTB), the underlying mechanism is largely ...
Clostridioides difficile-Derived Extracellular Vesicles Induce Proinflammatory Responses in Macrophages [0.03%]
难辨梭菌来源的细胞外囊泡诱导巨噬细胞产生促炎症反应
Fangfang Fan,Yu Zeng,Qianli Zhao et al.
Fangfang Fan et al.
Clostridioides difficile (CD) is a leading cause of antibiotic-associated diarrhoea in both hospitalized and non-hospitalized patients. This study explores the role of extracellular vesicles (EVs) derived from Clostridioides difficile strai...
Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis [0.03%]
莱什曼菌外泌体抗利什曼病预防性疫苗平台作用研究
Ismail Cem Yilmaz,Ibrahim Tokmak,Muzaffer Yildirim et al.
Ismail Cem Yilmaz et al.
Leishmaniasis, caused by Leishmania spp., is one of the most neglected tropical diseases and poses a serious threat to public health, accounting for at least one million new cases each year. There is no available human vaccine. In this stud...
Hyaluronic Acid Decoration Facilitates CD44-Mediated Targeting and Alters Protein Corona Formation of Extracellular Vesicles [0.03%]
透明质酸修饰促进细胞外囊泡的CD44介导靶向并改变其蛋白冠形成
Heikki Kyykallio,Elena Scurti,Martina Hanzlíková et al.
Heikki Kyykallio et al.
Cell recognition and uptake of extracellular vesicles (EVs) is mediated by a variety of surface molecules. Growing interest has recently been drawn towards glycan structures on EVs. Hyaluronic acid (HA) is a negatively charged glycosaminogl...
Application of Intracellular Vesicles Surpass Extracellular Vesicles in Regenerative Repair of Inflammatory Bone Defects via the LAMA4-Mediated YAP/TAZ Signalling [0.03%]
细胞内囊泡通过LAMA4介导的YAP / TAZ信号传导在炎症性骨缺损再生修复中的应用优于细胞外囊泡
Haotian Liu,Yu Wu,Qunyi Wang et al.
Haotian Liu et al.
Periodontitis-induced inflammatory microenvironment compromises the function of periodontal ligament stem cells (PDLSCs) and significantly impedes the regeneration of periodontal tissues. Meanwhile, the clinical application of extracellular...
Small and Large Extracellular Vesicles in Circulation of Diffuse Large B-Cell Lymphoma Patients Originate From Different Cell Types of the Tumor Microenvironment [0.03%]
弥漫性大B细胞淋巴瘤患者血液循环中的小型和大型细胞外囊泡源自肿瘤微环境的不同细胞类型
Filippo Maltoni,Steven Wang,Mischa F B Steketee et al.
Filippo Maltoni et al.
Malignant and non-malignant cells within the tumor microenvironment (TME) actively secrete extracellular vesicles (EVs) that may mediate intercellular communication or enter the blood stream. Circulating EVs in Diffuse Large B-Cell Lymphoma...
Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut-Liver Bacterial Translocation and Pro-Tumorigenic Processes [0.03%]
肠道共生菌肺炎克雷伯氏菌的胞外囊泡能形塑有利于肠肝细菌移位和促肿瘤进程的肝脏微环境
Shogo Tsubaki,Sho Nashimoto,Rika Tanaka et al.
Shogo Tsubaki et al.
Bacterial extracellular vesicles (EVs) are emerging mediators of host-microbe communication; however, their role in human disease remains unclear. Here, we identify two bacterial small tRNAs (tsRNAs) enriched in gut commensal Klebsiella pne...
Multicentre Evaluation of an AI-Assisted Urine Test for Clinically Significant Prostate Cancer in Men Undergoing Initial Biopsy [0.03%]
多中心评估人工智能辅助尿检在初始活检男性患者中检测临床显著性前列腺癌的效果
Shaoqin Jiang,Chunguang Yang,Zhangcheng Huang et al.
Shaoqin Jiang et al.
The Extracellular Vesicles Gene-based Prostate Score (EGPS), powered by DeepSeek, is an artificial intelligence (AI) diagnostic tool that enhances the detection of clinically significant prostate cancer (csPCa) using urinary EV-derived gene...
Multicenter Study
Journal of extracellular vesicles. 2026 Apr;15(4):e70233. DOI:10.1002/jev2.70233 2026
Podocyte-Derived Extracellular Vesicles Induce Endothelial Dysfunction by Triggering ER Stress in Glomerular Disease [0.03%]
podocyte 衍生的细胞外囊泡通过触发内质网压力诱导肾小球疾病的内皮功能障碍
Zhao Liu,Xi Liu,Xin Wen et al.
Zhao Liu et al.
Podocyte injury and endothelial cell dysfunction are the hallmarks of glomerular disease. How these two events are connected remains largely unknown. This study aimed to delineate the role of extracellular vesicles (EVs) in mediating podocy...