Bevacizumab in ovarian cancer: Clinical data and predictive and prognostic biomarkers [0.03%]
卵巢癌贝伐单抗的临床数据及其预测和预后生物标志物
Maria Rosaria Lamia,Erica Perri,Gustavo Baldassarre et al.
Maria Rosaria Lamia et al.
Angiogenesis, driven by the vascular endothelial growth factor (VEGF)/VEGFR signalling axis under hypoxic conditions, is one of the hallmarks of ovarian cancer (OC), contributing to tumour progression, metastatic dissemination and immune ev...
Phase II clinical trial of nirogacestat in patients with relapsed ovarian granulosa cell tumours [0.03%]
尼罗呱色替应用于复发性卵巢颗粒细胞肿瘤患者的II期临床试验
Rachel N Grisham,Elizabeth Hopp,Kathryn Pennington et al.
Rachel N Grisham et al.
Background: Adult ovarian granulosa cell tumours (GCT) are the most common subtype of ovarian sex cord-stromal tumours. Forkhead transcription factor FOXL2 is required for development and function of normal granulosa cell...
Targeted demethylation of the BRD7 promoter based on CRISPR/dCas9 system inhibits the malignant progression of nasopharyngeal carcinoma [0.03%]
基于CRISPR/dCas9系统的BRD7启动子去甲基化抑制鼻咽癌恶性进展
Jianxia Wei,Yumei Duan,Changning Xue et al.
Jianxia Wei et al.
Background: BRD7 has been confirmed to be lowly expressed in nasopharyngeal carcinoma (NPC) tissues and exerts tumour suppressive roles. However, the molecular mechanism of the downregulation of BRD7 expression and whethe...
Dual AAV gene therapy achieves recovery of hearing and auditory processing in a DFNB16 mouse model [0.03%]
双AAV基因治疗实现DFNB16小鼠模型听觉和听力恢复
Sepideh Iranfar,Sophie Bagur,Chloé Felgerolle et al.
Sepideh Iranfar et al.
Background: DFNB16, the second most common genetic cause of hearing loss, is caused by mutations of the STRC gene encoding stereocilin, a protein essential for the effective functioning of outer hair cells (OHCs) as cochl...
VAMP7-mediated autophagy regulates cervical cancer progression associated with persistent HPV16 infection [0.03%]
VAMP7介导的自噬调节持续性HPV16感染相关宫颈癌进展
Weijuan Xin,Junjie Zhang,Dan Wu et al.
Weijuan Xin et al.
Backgroud: Persistent infection with high-risk human papillomavirus type 16 (HPV16) is a principal etiological factor in cervical cancer. Nevertheless, the molecular events linking HPV16-associated lesion progression to m...
DNA methylation variability in pediatric aplastic anaemia contributes to T-cell differentiation [0.03%]
儿童再生障碍性贫血的DNA甲基化变异与T细胞分化有关
Junchen Lai,Fangli Chen,Yan Miao et al.
Junchen Lai et al.
Alterations of the immune microenvironment with age predicts patient prognosis of gastrointestinal tract tumours [0.03%]
免疫微环境的年龄相关改变可预测消化道肿瘤患者的预后
Fangzhen Li,Jingjing Chen,Junjie Wang et al.
Fangzhen Li et al.
Insulin resistance indicators in aortic disease: A large cohort study [0.03%]
主动脉疾病患者胰岛素抵抗指标的大样本队列研究
Zehua Shao,Zhongyuan Lu,Wanxin Duan et al.
Zehua Shao et al.
Background: The triglyceride-glucose index (TyG), a novel marker of insulin resistance, is recognised as a risk factor for multiple cardiovascular diseases. The link between its risk and aortic dissection and aortic aneur...
Single-molecule electrical protein fingerprinting in solid-state nanopores [0.03%]
固态纳米孔中的单分子电学蛋白质指纹识别技术
Neeraj Soni,Amit Meller
Neeraj Soni
Baseline multi-omics signatures could predict therapeutic response to neoadjuvant anti-PD-1 immunochemotherapy in non-small-cell lung cancer [0.03%]
基线多组学标志物能够预测新辅助抗PD-1免疫化疗在非小细胞肺癌中的治疗反应
Ailing Cao,Yaobin Lin,Shaoxing Guan et al.
Ailing Cao et al.
Background: Neoadjuvant anti-programmed cell death 1 (PD-1) immunochemotherapy has shown promising efficiency in the treatment of early-stage non-small-cell lung cancer (NSCLC), but it has not consistently yielded durable...