TIMP2 promotes AKI-CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β-catenin signalling [0.03%]
TIMP2通过靶向Wnt/β-catenin信号促进AKI-CKD的过渡，诱导上皮细胞适应不良修复和衰老
Dongxue Xu,Haichuan Yu,Jingjing Pang et al.
Dongxue Xu et al.
Background: Acute kidney injury (AKI) frequently progresses to chronic kidney disease (CKD), but the underlying mechanisms of this transition remain unclear. While TIMP2 is a known biomarker for AKI, its direct pathogenic...
High-throughput single-cell DNA methylation and chromatin accessibility co-profiling with SpliCOOL-seq [0.03%]
基于SpliCOOL-seq的高通量单细胞DNA甲基化和染色质可及性联合测序技术
Qingmei Shen,Enze Deng,Ling Luo et al.
Qingmei Shen et al.
Background: DNA methylation and chromatin accessibility are pivotal epigenetic regulators of gene expression and cellular identity, with significant implications in tumorigenesis and progression. Current single-cell multi...
DNTTIP1 drives leukaemogenesis through MiDAC-mediated epigenetic silencing of BMF [0.03%]
DNTTIP1通过MiDAC介导的BMF表观遗传沉默促进白血病发生发展
Ruolin Xiu,Yuzhu Ma,Yueying Gao et al.
Ruolin Xiu et al.
Background: Acute leukaemia is a highly aggressive malignancy with significant unmet therapeutic needs, partly due to epigenetic dysregulation. Here, we uncover deoxynucleotidyl transferase terminal-interacting protein 1 ...
deltaHED predicts survival and immune evasion in PD-1 blockade therapy: A multi-cohort study across three cancer types [0.03%]
预测PD-1阻断疗法生存率和免疫逃逸的deltaHED：三种癌症类型的多队列研究
Jianying Xu,Xiaoli Wei,Jicheng Yao et al.
Jianying Xu et al.
The prognostic relevance of HLA class I (HLA-I)-mediated immunity in cancer immunotherapy remains unclear. We introduce deltaHED, a novel metric that quantifies evolutionary divergence between germline and tumour-acquired HLA-I alleles, int...
Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic-cell clearance to therapeutic targeting [0.03%]
肿瘤微环境中促凋亡细胞吞噬的代谢重构：从凋亡细胞清除到治疗靶向
Qianlu Yang,Jie Yan,Qianxi Yang
Qianlu Yang
Background: Efferocytosis is a critical physiological process in which phagocytes clear apoptotic cells to maintain tissue homeostasis. However, within the tumour microenvironment (TME), this process is systematically hij...
Quantum medicine: A quantum-mechanical framework for redox biology, disease and precision medicine [0.03%]
量子医学：还原生物学、疾病和精确医学的量子力学框架
Ji-Yong Sung,Jae-Ho Cheong
Ji-Yong Sung
Background: Key biological processes underlying health and disease-including electron transfer, redox regulation, and radical-mediated signaling-are fundamentally governed by quantum-mechanical principles. These processes...
Plasma cell-free DNA markers predict occult metastases in patients with resectable pancreatic ductal adenocarcinoma [0.03%]
血浆游离DNA标志物可预测可切除型胰腺导管腺癌患者的隐匿性转移病灶
Jacob E Till,Ofer Gal-Rosenberg,Sophia G Giliberto et al.
Jacob E Till et al.
Regulatory mechanism of O-linked N-acetylglucosamine protein modification on autophagy in cancer [0.03%]
O-连接的N-乙酰氨基葡萄糖蛋白质修饰调控自噬在肿瘤中的作用机制研究
Yizhan Li,Ling Gao,Shaoming Li et al.
Yizhan Li et al.
Background: O-linked N-acetylglucosamine protein modification (O-GlcNAcylation) is a dynamic, nutrient-sensitive post-translational modification frequently upregulated in cancers. Autophagy, a lysosome-dependent recycling...
Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance [0.03%]
合成致死性在癌症治疗中的作用：机制、模型及临床转化以克服治疗耐药性
Junyan Li,Liyuan Zhang,Yan Shang et al.
Junyan Li et al.
Background and rationale: Synthetic lethality (SL)-based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, ...
Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis [0.03%]
ENO1乳酰化靶向治疗改善脓毒症内皮细胞功能障碍
Xueru Xie,Tingyan Liu,Caiyan Zhang et al.
Xueru Xie et al.
Background: Elevated lactate is associated with vascular endothelial dysfunction, a factor that can contribute to organ failure in sepsis. However, the specific mechanisms involved have yet to be fully elucidated. Here, w...