Dissecting diffuse large B-cell lymphoma heterogeneity: New insights from a state-specific molecular characterisation [0.03%]
Robel Papotti,Filippo Vit,Tamara Bittolo et al.
Robel Papotti et al.
Background: Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease. Methods: In this study, we an...
Sreenidhi Mohanvelu,Poorvi Subramanian,Sheeja Aravindan et al.
Sreenidhi Mohanvelu et al.
Background: Promyelocytic leukaemia protein (PML), a key regulator of nuclear architecture and cellular homeostasis, is increasingly recognised for its tumour-suppressive functions. In neuroblastoma (NBL), a clinically he...
Interferon-induced transmembrane (IFITM) proteins at the tumour-immune interface: A four-axis framework for their context-dependent roles [0.03%]
Zhe Liu,Jie Meng,Zengyan Lai et al.
Zhe Liu et al.
Background: The interferon-induced transmembrane (IFITM) protein family, including IFITM1, IFITM2, IFITM3, and the less-characterized IFITM5 and IFITM10, has emerged as a recurrent yet mechanistically complex group of pla...
ETS1-EGR2 facilitates renal cell carcinoma progression by activating NOTCH signalling [0.03%]
ETS1-EGR2通过激活NOTCH信号促进肾细胞癌进展
Weifeng Ye,Sishun Gan,Qiang Xu et al.
Weifeng Ye et al.
Background: Renal cell carcinoma (RCC) is known as one of the three major malignant tumors of the urinary system, and clear-cell RCC (ccRCC) is the most frequent and aggressive pathological subtype and is correlated with ...
Germline predisposition and somatic mutational landscape in synchronous mucinous metaplasia and neoplasia of the female genital tract [0.03%]
女性生殖道黏液性 metaplasia 和 neoplasia 的遗传易感性及体细胞性染色体变异景观分析
Ying Yuan,Li Zhang,Jiongbo Liao et al.
Ying Yuan et al.
Background: Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT) with gastric-type differentiation is a rare disorder with genetic predisposition. Pathogenic STK11 variants explain only a m...
ROS-ATM-CBP axis-mediated PARP1 lactylation aggravates doxorubicin-induced cardiotoxicity [0.03%]
ROS-ATM-CBP轴介导的PARP1糖基化加重多柔比星致心脏毒性
Wenbin Wang,Yingxian Sun
Wenbin Wang
Doxorubicin (DOX) is a potent antineoplastic agent, but its clinical application is limited by the life-threatening cardiotoxic effects. Poly(ADP-ribose) polymerase 1 (PARP1) transfers ADP-ribose groups from donor NAD+ molecules onto target...
Space radiation impairs long-term endothelial integrity and may promote atherosclerosis in ApoE-deficient mice [0.03%]
太空辐射损害长期内皮完整性并可能会促进载脂蛋白E缺乏型小鼠动脉粥样硬化发展
Yang Xu,Sabrina Jarrah,Shihong Zhang et al.
Yang Xu et al.
Space radiation impairs long-term endothelial integrity and may promote atherosclerosis in ApoE-deficient mice [0.03%]
太空辐射损害长期内皮完整性并可能促进ApoE基因缺陷型小鼠动脉粥样硬化发展
Yang Xu,Sabrina Jarrah,Shihong Zhang et al.
Yang Xu et al.
Space radiation impairs long-term endothelial integrity and may promote atherosclerosis in ApoE-deficient mice [0.03%]
太空辐射损害长期内皮完整性能促进ApoE基因缺陷小鼠动脉粥样硬化的发展
Yang Xu,Sabrina Jarrah,Shihong Zhang et al.
Yang Xu et al.
Integrin α5β1 in pancreatic ductal adenocarcinoma: Tumour‒stroma crosstalk, hypoxia and therapeutic targeting [0.03%]
整合素α5β1在胰腺导管腺癌中的作用：肿瘤-基质相互作用、缺氧和治疗靶向
Chenzhe Ma,Yingying Wang,Yumin Li
Chenzhe Ma
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies and is characterised by aggressive biological behaviour, marked therapeutic resistance and a dense desmoplastic tumour microenviro...