Regulatory mechanism of O-linked N-acetylglucosamine protein modification on autophagy in cancer [0.03%]
O-连接的N-乙酰氨基葡萄糖蛋白质修饰调控自噬在肿瘤中的作用机制研究
Yizhan Li,Ling Gao,Shaoming Li et al.
Yizhan Li et al.
Background: O-linked N-acetylglucosamine protein modification (O-GlcNAcylation) is a dynamic, nutrient-sensitive post-translational modification frequently upregulated in cancers. Autophagy, a lysosome-dependent recycling...
Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance [0.03%]
合成致死性在癌症治疗中的作用：机制、模型及临床转化以克服治疗耐药性
Junyan Li,Liyuan Zhang,Yan Shang et al.
Junyan Li et al.
Background and rationale: Synthetic lethality (SL)-based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, ...
Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis [0.03%]
ENO1乳酰化靶向治疗改善脓毒症内皮细胞功能障碍
Xueru Xie,Tingyan Liu,Caiyan Zhang et al.
Xueru Xie et al.
Background: Elevated lactate is associated with vascular endothelial dysfunction, a factor that can contribute to organ failure in sepsis. However, the specific mechanisms involved have yet to be fully elucidated. Here, w...
Long non-coding RNA lncAPAT promotes atherosclerotic plaque instability by targeting ribosomal protein L22 [0.03%]
长非编码RNA lncAPAT通过靶向核糖体蛋白L22促进动脉粥样硬化斑块不稳定性
Rongxia Li,Qiyue Zhang,Yu Chen et al.
Rongxia Li et al.
Background: Long non-coding RNAs (lncRNAs) regulate macrophage inflammation and atherosclerotic plaque stability, but mechanisms need comprehensive investigations. ...
Decoding innate lymphoid cell heterogeneity and plasticity in colorectal cancer [0.03%]
解码结直肠癌固有淋巴样细胞异质性和可塑性
Shuomin Zhang,Qingfeng Fu,Zhengyang Xu et al.
Shuomin Zhang et al.
Background: In colorectal cancer (CRC), innate lymphoid cells (ILCs) play a vital role in preserving and modulating immune homeostasis within the intestinal environment. However, the origins and diverse functions of ILCs ...
Bevacizumab in ovarian cancer: Clinical data and predictive and prognostic biomarkers [0.03%]
卵巢癌贝伐单抗的临床数据及其预测和预后生物标志物
Maria Rosaria Lamia,Erica Perri,Gustavo Baldassarre et al.
Maria Rosaria Lamia et al.
Angiogenesis, driven by the vascular endothelial growth factor (VEGF)/VEGFR signalling axis under hypoxic conditions, is one of the hallmarks of ovarian cancer (OC), contributing to tumour progression, metastatic dissemination and immune ev...
Phase II clinical trial of nirogacestat in patients with relapsed ovarian granulosa cell tumours [0.03%]
尼罗呱色替应用于复发性卵巢颗粒细胞肿瘤患者的II期临床试验
Rachel N Grisham,Elizabeth Hopp,Kathryn Pennington et al.
Rachel N Grisham et al.
Background: Adult ovarian granulosa cell tumours (GCT) are the most common subtype of ovarian sex cord-stromal tumours. Forkhead transcription factor FOXL2 is required for development and function of normal granulosa cell...
Targeted demethylation of the BRD7 promoter based on CRISPR/dCas9 system inhibits the malignant progression of nasopharyngeal carcinoma [0.03%]
基于CRISPR/dCas9系统的BRD7启动子去甲基化抑制鼻咽癌恶性进展
Jianxia Wei,Yumei Duan,Changning Xue et al.
Jianxia Wei et al.
Background: BRD7 has been confirmed to be lowly expressed in nasopharyngeal carcinoma (NPC) tissues and exerts tumour suppressive roles. However, the molecular mechanism of the downregulation of BRD7 expression and whethe...
Dual AAV gene therapy achieves recovery of hearing and auditory processing in a DFNB16 mouse model [0.03%]
双AAV基因治疗实现DFNB16小鼠模型听觉和听力恢复
Sepideh Iranfar,Sophie Bagur,Chloé Felgerolle et al.
Sepideh Iranfar et al.
Background: DFNB16, the second most common genetic cause of hearing loss, is caused by mutations of the STRC gene encoding stereocilin, a protein essential for the effective functioning of outer hair cells (OHCs) as cochl...
VAMP7-mediated autophagy regulates cervical cancer progression associated with persistent HPV16 infection [0.03%]
VAMP7介导的自噬调节持续性HPV16感染相关宫颈癌进展
Weijuan Xin,Junjie Zhang,Dan Wu et al.
Weijuan Xin et al.
Backgroud: Persistent infection with high-risk human papillomavirus type 16 (HPV16) is a principal etiological factor in cervical cancer. Nevertheless, the molecular events linking HPV16-associated lesion progression to m...