Long-term trends in metabolic profiles across Chinese birth cohorts: A real-world big data analysis [0.03%]
中国出生队列的长期代谢谱特征变化趋势——基于真实世界大数据的分析
Ying Xiong,Xincen Duan,Jing Zhu et al.
Ying Xiong et al.
Background: The global burden of metabolic diseases is increasingly severe, with a continuous rise in prevalence among younger populations. There is an urgent need to explore the long-term trends of metabolic risk factors...
Lysine lactylation-mediated post-translational modification: Molecular mechanisms and therapeutic target exploration in tumour drug resistance [0.03%]
赖氨酸乳酰化介导的翻译后修饰：肿瘤耐药中的分子机制及治疗靶标探索
Juan Li,Yan Shang,Haojie Wu et al.
Juan Li et al.
Background: Tumour drug resistance remains a major hurdle in cancer treatment, with post-translational modifications (PTMs) playing a pivotal role in this process. Lysine lactylation (Kla), a newly identified PTM, is tigh...
PPP2R3C serves as a negative regulator associated with reduced T cell hyperactivation and renal protection in lupus [0.03%]
PPP2R3C作为负调节因子通过抑制T细胞过度活化发挥狼疮肾保护作用
Xuan Fang,Yi Qin,Jinhui Tao et al.
Xuan Fang et al.
Background: CD4+ T cell hyperactivation is a pivotal driver of systemic autoimmunity in systemic lupus erythematosus (SLE), yet the molecular regulators that set its activation threshold remain poorly defined. ...
Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics [0.03%]
乳酸代谢和乳酰化在女性生殖疾病中的作用：从代谢重组到生物标志物及转化治疗
Jiajun Qiao,Yue Xiao,Yi Cheng et al.
Jiajun Qiao et al.
Background: Lactate is increasingly recognized not only as a metabolic end product of glycolysis but also as a signaling metabolite that links metabolic reprogramming to epigenetic and transcriptional regulation through p...
DCLK1-dependent NF-κB activation mediates p-STAT3-induced osteoarthritis progression [0.03%]
DCLK1依赖的NF-κB激活介导p-STAT3诱导的骨关节炎进展
Pengfei Li,Chipiu Wong,Yuqiang Wang et al.
Pengfei Li et al.
Background: Osteoarthritis (OA) is a widespread degenerative joint disorder marked by irreversible cartilage destruction. While signal transducer and activator of transcription 3 (STAT3) is recognised as a pivotal regulat...
miR-941 in extracellular vesicles confers anlotinib resistance via Keap1/Nrf2 axis and represents a therapeutic target in non-small cell lung cancer [0.03%]
细胞外囊泡中的miR-941通过Keap1/Nrf2轴介导阿帕替尼耐药并可在非小细胞肺癌中作为治疗靶点
Aimi Huang,Xiaoqi Li,Erpeng Wu et al.
Aimi Huang et al.
Background: Anlotinib is a multitargeted tyrosine kinase inhibitor for the treatment of advanced non-small cell lung cancer (NSCLC), though its therapeutic efficacy is constrained by acquired resistance. Although elevated...
Inducible CRISPR/Cas systems in precision oncology: Current applications and future perspectives [0.03%]
基于CRISPR/Cas系统的精准肿瘤学：当前应用与未来前景
Ziliang Ding,Yukun Wei,Yong Han et al.
Ziliang Ding et al.
Background: Inducible CRISPR/Cas systems enable spatiotemporal control of genome editing in response to chemical, optical, biological, or physical stimuli. By restricting genome-editing activity to defined conditions, the...
Super-enhancer-driven KIAA1522 upregulation suppresses ferroptosis in hepatocellular carcinoma [0.03%]
肝细胞癌中超级增强子驱动的KIAA1522上调抑制铁死亡现象
Xinyang Li,Siyuan Hu,Haolin Shi et al.
Xinyang Li et al.
Background: Aberrantly activated super-enhancers (SEs) drive hepatocellular carcinoma (HCC) malignancy. However, the sustained oncogenic mechanisms mediated by SE-driven genes remain elusive. ...
NAT10-mediated N4-acetylcytidine modification drives RNA splicing of PML to alleviate adipose-derived stem cell senescence and promote diabetic wound healing [0.03%]
NAT10介导的N4-乙酰基胞苷修饰驱动PML mRNA剪接，抑制糖尿病创面脂肪源间充质干细胞衰老以促进伤口愈合
Wuhan Wei,Chanyuan Jiang,Dong Zhu et al.
Wuhan Wei et al.
Background: Cellular senescence of adipose-derived stem cells (ADSCs) compromises their therapeutic potential in diabetic wound healing. Alternative splicing produces functionally different variants and serves as a critic...
Refining inflammatory profiles linked to cardiometabolic outcomes in people with HIV using recursive feature addition modelling [0.03%]
使用递归特征添加模型 refinement 与 HIV 携带者心血管代谢结果相关的炎症谱型
Rachel MacCann,Dana Alalwan,Gurvin Saini et al.
Rachel MacCann et al.