Integrative single-cell analysis uncovers distinct tumour microenvironment ecotypes and immune evasion across skin cancers [0.03%]
整合单细胞分析揭示了皮肤癌中不同的肿瘤微环境生态型和免疫逃逸现象
Lingjuan Huang,Huihui Hou,Xiyuan Zhang et al.
Lingjuan Huang et al.
Background: Skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), cutaneous melanoma (CM) and acral melanoma (AM), exhibit profound heterogeneity in clinical behaviour and therapeutic response...
Single-cell and spatial transcriptomics uncover neoadjuvant chemotherapy-resistant malignant cells with inhibitory signalling on B cells in gastric cancer [0.03%]
单细胞和空间转录组揭示胃癌新辅助化疗抵抗性恶性肿瘤细胞对B细胞的抑制信号
Pei-Yi Han,Xiang-Xi Ye,Xiao Yang et al.
Pei-Yi Han et al.
T-cell exhaustion from a multiomics perspective: Differentiation mechanisms and regulatory networks in the journey from progenitor-Exhausted T cells to terminally exhausted T cells [0.03%]
多组学视角下的T细胞耗竭：从前体耗竭T细胞到终末期耗竭T细胞的分化机制和调控网络
Tong Zhu,Xiaoyu Teng,Qinlian Jiao et al.
Tong Zhu et al.
A central hurdle limiting the success of T-cell-based immunotherapies is the progressive dysfunction of T cells, known as exhaustion. Overcoming this exhausted state is therefore a pivotal objective in translational oncology and immunology....
How generative AI reconfigure clinician-AI and clinician-patient relationships [0.03%]
生成式AI如何重新配置临床医生与AI及临床医生与患者之间的关系
Tianyi Shen,Xinru Wang,Yajuan Zhang et al.
Tianyi Shen et al.
Bioswitches: Towards programmable, on-demand control of therapeutic proteins [0.03%]
生物开关：针对治疗性蛋白质实现可编程的按需控制
Benedict Wolf,Jan Mathony,Dominik Niopek
Benedict Wolf
Lei Wang,Qian Dong,Fuchu He et al.
Lei Wang et al.
Lysozyme (LYZ) is a naturally occurring antimicrobial protein first discovered in the 1920s. As a key component of innate immunity, its antimicrobial effects and immunomodulatory functions in bacterial defence have been extensively characte...
Adipocyte fatty acid-binding protein as a cerebrospinal fluid-accessible biomarker and druggable target in subarachnoid haemorrhage: Linking fatty acid dysregulation to microglial neuroinflammation [0.03%]
脂肪细胞脂肪酸结合蛋白作为蛛网膜下腔出血的脑脊液可检测生物标志物和潜在药物靶点：连接脂肪酸失调与小胶质细胞神经炎症
Xingwu Liu,Shenquan Guo,Xin Feng et al.
Xingwu Liu et al.
Background: Subarachnoid haemorrhage (SAH), a devastating subtype of stroke, is predominantly caused by the rupture of intracranial aneurysms. Emerging evidence indicates that the risk of intracranial aneurysm rupture cor...
Comprehensive tumour-immune profiling reveals TREM2+ tumour-associated macrophages facilitating lymph node metastasis in head and neck squamous cell carcinoma [0.03%]
全面的肿瘤免疫谱分析揭示TREM2+肿瘤相关巨噬细胞在头颈鳞状细胞癌淋巴结转移中的作用
Zhuokai Wu,Chixing Cheng,Zhaoxin Li et al.
Zhuokai Wu et al.
Background: Lymph node (LN) metastasis is a well-established independent prognostic factor in head and neck squamous cell carcinoma (HNSCC). Formation of suppressive tumour immune microenvironment (TIME) is a major contri...
TIMP2 promotes AKI-CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β-catenin signalling [0.03%]
TIMP2通过靶向Wnt/β-catenin信号促进AKI-CKD的过渡，诱导上皮细胞适应不良修复和衰老
Dongxue Xu,Haichuan Yu,Jingjing Pang et al.
Dongxue Xu et al.
Background: Acute kidney injury (AKI) frequently progresses to chronic kidney disease (CKD), but the underlying mechanisms of this transition remain unclear. While TIMP2 is a known biomarker for AKI, its direct pathogenic...
High-throughput single-cell DNA methylation and chromatin accessibility co-profiling with SpliCOOL-seq [0.03%]
基于SpliCOOL-seq的高通量单细胞DNA甲基化和染色质可及性联合测序技术
Qingmei Shen,Enze Deng,Ling Luo et al.
Qingmei Shen et al.
Background: DNA methylation and chromatin accessibility are pivotal epigenetic regulators of gene expression and cellular identity, with significant implications in tumorigenesis and progression. Current single-cell multi...