Ninjurin1 in cardiovascular and vascular biology: From molecular mechanisms to therapeutic opportunities [0.03%]
Ninjurin1在心血管和血管生物学中的作用：从分子机制到治疗机会
Muhammad Mamunur Rashid Mahib
Muhammad Mamunur Rashid Mahib
Background: Ninjurin1 (NINJ1) is a transmembrane protein originally identified as a nerve injury-induced adhesion molecule. Recent discoveries have revealed its essential role in plasma membrane rupture (PMR) during lytic...
The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling [0.03%]
ACSL家族在癌症中的多面作用：代谢重编程、铁死亡调节和肿瘤免疫微环境重塑
Haocai Li,Weijian Wang,Juncheng Zhan et al.
Haocai Li et al.
Background: Metabolic reprogramming is a key cancer hallmark, with dysregulated fatty acid metabolism critical for tumorigenesis and progression. The acyl-CoA synthetase long-chain (ACSL) family (ACSL1-ACSL6) catalyzes AT...
ALKBH3 suppresses ischemia/reperfusion-induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation [0.03%]
通过m1A去甲基化调节ZBED6 / STAT1 / AIM2轴抑制ALKBH3缺血/再灌注诱导的PANoptosis
Hongtao Diao,Chunlei Wang,Yuting Xiong et al.
Hongtao Diao et al.
Background: Myocardial ischemia/reperfusion (I/R) injury induces an intense inflammatory response and involves multiple cell death pathways. PANoptosis, an integrated cell death process involving pyroptosis, apoptosis and...
Multi-omic profiling defines three distinct molecular subtypes of urothelial carcinoma with implications for precision therapy [0.03%]
多组学谱分析定义了尿路上皮癌三种分子亚型及其对精确诊疗的意义
Nils C H van Creij,Piotr Tymoszuk,Florian Handle et al.
Nils C H van Creij et al.
Background: Urothelial carcinoma (UC) is a biologically heterogeneous disease, and current molecular classifications have limited integration into clinical decision-making. To further pursue precision oncology efforts in ...
Lactate-induced metabolic reprogramming of TAMs impairs antigen presentation capacity via C/EBPα-CD74 axis in oral squamous cell carcinoma [0.03%]
乳酸通过C/EBPα-CD74轴诱导肿瘤相关巨噬细胞代谢重编程从而抑制口腔鳞状细胞癌中抗原呈递能力
Mengyao Wang,Mengqi Wang,Zizhen Gong et al.
Mengyao Wang et al.
Background: Throughout oral squamous cell carcinoma (OSCC) progression, tumor-associated macrophages (TAMs) lose their antigen-presenting capacity and anti-tumor function. The mechanisms that cause this dysfunction are no...
CMA-mediated USP9X degradation promotes SHH medulloblastoma progression by facilitating SUFU ubiquitination [0.03%]
由CMA介导的USP9X降解通过促进SUFU泛素化来促进SHH型髓母细胞瘤进展
Binbin Gao,Qin Zhu,Lun Kuang et al.
Binbin Gao et al.
Background: Medulloblastoma (MB) represents the most prevalent malignant paediatric brain tumour, characterised by the sonic Hedgehog molecular subtype (SHH-MB), which is driven by aberrant activation of the SHH signallin...
Macrophage-derived galectin-3 contributes to pyroptosis, apoptosis and necroptosis through TLR4/MyD88/NF-κB/NLRP3 during atherosclerosis [0.03%]
巨噬细胞来源的半乳糖凝集素-3通过TLR4/MyD88/NF-κB/NLRP3诱导动脉粥样硬化中的pyroptosis，凋亡和necroptosis
Zihui Yuan,Haitao Li,Bing Xing Ruan et al.
Zihui Yuan et al.
Background: Pyroptosis, apoptosis and necroptosis (PANoptosis) simultaneously occur and are extensively cross-linked in infectious and inflammatory diseases. However, the co-existence and regulation of macrophage pyroptos...
Clonal haematopoiesis in chronic lymphocytic leukaemia: Biology, inflammaging and clinical implications in the era of targeted therapy [0.03%]
慢性淋巴细胞性白血病中的克隆性血液生成：靶向治疗时代的生物学、炎症老化及临床意义
Enrica Antonia Martino,Santino Caserta,Mamdouh Skafi et al.
Enrica Antonia Martino et al.
Background: Clonal haematopoiesis (CH) is an age-related condition increasingly recognised for its relevance in haematologic malignancies. In chronic lymphocytic leukaemia (CLL), its prevalence and clinical implications a...
Unveiling miR-451a and miR-142-3p as prognostic markers in non-small cell lung cancer via small extracellular vesicle liquid biopsy [0.03%]
通过小型细胞外囊泡液体活检在非小细胞肺癌中揭示范miR-451a和miR-142-3p作为预后标志物的作用
Miranda Burdiel,Ana Arauzo-Cabrera,Julia Jiménez et al.
Miranda Burdiel et al.
Single-cell multi-omics analysis of the tumour microenvironment for colorectal cancer liver metastasis [0.03%]
结直肠癌肝转移肿瘤微环境的单细胞多组学分析
Jiao Guan,Mingwei Guo,Min Hu et al.
Jiao Guan et al.