Mechanism of Gzma-mediated GEF-H1 activation in intestinal epithelial cells leading to intestinal barrier dysfunction in sepsis [0.03%]
GzmB介导的GEF-H1活化促进脓毒症小肠上皮细胞屏障损伤的作用机制研究
Zexing Lin,Haiyang Jiang,Chujun Ni et al.
Zexing Lin et al.
Background: Sepsis-induced intestinal injury is a severe complication associated with dysfunction affecting multiple organ systems and a significantly elevated risk of death. Intestinal barrier dysfunction plays a central...
Targeting KIF23 inhibits cell proliferation and primary chemoresistance in cervical cancer by inactivating the MYH9/MCM2/PCNA pathway [0.03%]
靶向KIF23通过抑制MYH9/MCM2/PCNA途径来抑制宫颈癌的细胞增殖和初始化学抗性
Ying Zhu,Qian Wang,Yilin Zhang et al.
Ying Zhu et al.
Background: Kinesin family member 23 (KIF23) is recognised as an important tumour promoter involved in the pathogenesis of various cancers. However, its role and underlying molecular mechanisms in regulating cervical canc...
Integrated multi-regional multiomic profiling of breast phyllodes tumours reveals peritumoural immune activation and stromal remodelling [0.03%]
乳腺叶状肿瘤的综合多区域多组学特征揭示了瘤周免疫激活和间质重塑
Tian-Qi Gu,Lei Wang,Xiang-Rong Wu et al.
Tian-Qi Gu et al.
Background: Breast malignant phyllodes tumours are rare fibroepithelial neoplasms arising from periductal stromal cells, characterized by rapid progression and a high recurrence rate. The poor prognosis largely stems from...
ZFP36L1 promotes non-small cell lung cancer progression under hypoxia by modulating CXCL9:SPP1 polarity: A single-cell transcriptomic study [0.03%]
缺氧下ZFP36L1通过调节CXCL9:SPP1极性促进非小细胞肺癌进展：单细胞转录组学研究
Lijie Wang,Biao Chen,Jinxian He et al.
Lijie Wang et al.
Background: Non-small cell lung cancer (NSCLC) is the predominant lung cancer subtype with high mortality rate. Drug resistance and immune evasion limit its therapeutic outcomes. Specific mechanism of the oncogenic ZFP36L...
Establishment of a canine urothelial carcinoma-derived organoid biobank: A platform for comparative and translational research [0.03%]
建立犬膀胱肿瘤类器官生物库：比较和转化研究的平台
Christopher Zdyrski,Aleksandra Pawlak,Hannah F Nicholson et al.
Christopher Zdyrski et al.
A novel MMP13 frameshift variant causes short stature via enhanced MMP13-HSPA5 interaction and activated endoplasmic reticulum stress [0.03%]
一个新的MMP13框移突变通过增强的MMP13-HSPA5相互作用和激活的内质网应激导致生长迟缓
Huifei Lu,Xin Feng,Suping Dai et al.
Huifei Lu et al.
Background: Short stature (SS) is a common growth disorder with multiple aetiologies. Variants in the MMP13 gene can result in varying degrees of SS, typically accompanied by pronounced skeletal abnormalities. This study ...
Tumour-targeted fluorescence-guided surgery in gastrointestinal cancer: A systematic review of preclinical and clinical research [0.03%]
胃肠癌肿瘤靶向荧光引导手术的系统性综述：从临床前研究到临床研究
Aaya Darai,Evie H M Graus,Femke J A van der Stroom et al.
Aaya Darai et al.
Background: Gastrointestinal cancers remain a leading cause of cancer-related morbidity and mortality worldwide, with surgery being central to curative treatment. Tumour-targeted fluorescence-guided surgery (tFGS) has eme...
Liquid biopsy biomarkers for early detection of gastrointestinal cancers: Current landscape and emerging technologies [0.03%]
胃肠癌症早期检测的液体活检标志物：现状与新兴技术
Muhammad Anees,Christopher Sherry,Hyun Y Park et al.
Muhammad Anees et al.
Early detection of gastrointestinal (GI) cancers remains a critical unmet clinical need, as most patients are diagnosed at advanced stages when prognosis is poor. Liquid biopsy has emerged as a transformative approach for minimally invasive...
Esketamine hydrochloride in the management of moderate-to-severe depressive symptoms in patients undergoing multiple wound repair surgeries: A multi-centre randomized, double-blind, placebo-controlled trial [0.03%]
氯 esketamine 在多处伤口修复手术患者的中重度抑郁症状管理中的应用：一项多中心随机、双盲、安慰剂对照试验
Xiaomeng Yu,Tianqi Shen,Ting Zhang et al.
Xiaomeng Yu et al.
Introduction: Patients undergoing multiple wound repair surgeries often develop moderate-to-severe anxiety and depression. However, there is a lack of effective rapid emotional intervention strategies during the periopera...
Randomized Controlled Trial
Clinical and translational medicine. 2026 Mar;16(3):e70641. DOI:10.1002/ctm2.70641 2026
A novel integrated miRNA-donor age signature enables detection of cardiac allograft vasculopathy [0.03%]
一种新型整合的miRNA-供体年龄特征可用于检测心脏移植物血管病
Irene González-Torrent,Carlota Benedicto,Marta Delgado-Arija et al.
Irene González-Torrent et al.