Physical exercise mitigates chronic psychological stress-induced vascular inflammation via the BDNF-Kif4-TARM1 axis [0.03%]
运动通过脑源性神经营养因子-动力相关蛋白4-靶向相互作用脂质代谢调节剂轴缓解慢性心理压力引起的血管炎症反应
Xianghui Zheng,Yunqi Li,Peiyao Wang et al.
Xianghui Zheng et al.
Background: Chronic psychological stress drives neuroimmune crosstalk and accelerates atherosclerosis progression. Physical exercise confers broad health benefits and is associated with reduced inflammation. However, the ...
Re-analysis of single-cell transcriptomics reveals a critical role of TNS1 gene in driving contractile VSMC transdifferentiation into macrophage-like SMC and atherosclerotic plaque instability [0.03%]
单细胞转录组学再分析揭示TNS1基因在驱动血管平滑肌细胞向巨噬细胞样平滑肌细胞转化和动脉粥样硬化斑块不稳定性中的关键作用
Shuang Yang,Rui Fu,Xiaoxiao Ren et al.
Shuang Yang et al.
Background: Vascular smooth muscle cell (VSMC) phenotype switching plays a significant role in the pathogenesis of atherosclerosis (AS). However, the subtypes of VSMC transdifferentiation and their impact on AS progressio...
Spatial and single-cell RNA sequencing reveals the immune microenvironment of human ascending thoracic aortic aneurysms [0.03%]
空间和单细胞RNA测序揭示人类升主动脉瘤免疫微环境
Ke Zhen,Zhiyong Du,Pengcheng Wang et al.
Ke Zhen et al.
Background: Ascending thoracic aortic aneurysm (ATAA) is a fatal vascular disease characterized by immune dysregulation. However, the cellular composition, spatial localization, and functional diversity of immune cells in...
Novel insights into extracellular vesicles: An update on biomolecules, immunomodulation and clinical strategies in skin melanoma [0.03%]
关于皮肤黑色素瘤中外泌体新见解：生物分子、免疫调节和临床策略的最新研究进展
Junshu Li,Wencheng Zhou,Ying Cen et al.
Junshu Li et al.
Extracellular vesicles (EVs) have become key mediators of intercellular communication in melanoma cells and significantly affect disease progression by delivering bioactive molecules. EVs are loaded with a wide variety of biomolecule carrie...
A droplet that releases stress: Drop-printing for conformal bioelectronics at neural and soft-tissue interfaces [0.03%]
一种释放应力的液滴：用于神经和软组织界面的生物电子器件的液滴打印技术
Qin Xu,Jiang Li,Xingyu Yang et al.
Qin Xu et al.
Rezvilutamide plus docetaxel in chemotherapy-naive metastatic castration-resistant prostate cancer patients after progression on abiraterone: A multi-centre, open-label, phase II trial [0.03%]
瑞普利木单抗联合多西他赛治疗阿比特龙进展后化疗初治的转移性去势抵抗性前列腺癌患者：一项多中心、开放标签II期试验
Zhenhua Liu,Bo Chen,Tao Dai et al.
Zhenhua Liu et al.
Background: A multi-centre, 2-part, phase II study assessed adding rezvilutamide (a novel androgen receptor antagonist) to docetaxel in abiraterone-refractory, metastatic castration-resistant prostate cancer (mCRPC) patie...
Targeting SLC5A2 suppresses colorectal tumour development by enhancing NK cell activity through extracellular vesicle-dependent MICA/B signalling [0.03%]
靶向SLC5A2通过细胞外囊泡依赖的MICA/B信号增强NK细胞活性从而抑制结直肠肿瘤发生
Jun Xiao,Jianghua Wu,Fengliu Deng et al.
Jun Xiao et al.
Tumour metabolic modulation represents a promising adjuvant therapeutic strategy for cancers, including colorectal cancer (CRC). Dapagliflozin, a clinically approved sodium‒glucose cotransporter 2 (SLC5A2/SGLT2) inhibitor, has attracted co...
Eva Breyer,Federico Baltar
Eva Breyer
Tissue-derived extracellular vesicle profiling identifies GLUT1 enabling ultrasensitive circulating quantification and early detection of non-small cell lung cancer [0.03%]
组织来源的外泌体鉴定出GLUT1使非小细胞肺癌的超灵敏量化和早期检测成为可能
Heng Huang,Taketo Kato,Yuichi Abe et al.
Heng Huang et al.
PVT1-104aa derived from the 8q24 gene desert promotes colorectal cancer tumorigenesis [0.03%]
源自8q24基因沙漠的PVT1-104aa促进结直肠癌的发生发展
Maoguang Ma,Mingdian Wang,Yufei Yang et al.
Maoguang Ma et al.
Background: Current therapeutic outcomes for advanced colorectal cancer (CRC) remain suboptimal, and chemotherapy-based regimens continue to be the mainstay of treatment. Circular RNAs (circRNAs) can serve as templates fo...