LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A [0.03%]
长链非编码RNA NEAT1通过KIF11依赖性抑制CDKN2A来抑制肝细胞癌的衰老反应
Danlei Chen,Jinghao Wang,Yang Li et al.
Danlei Chen et al.
Background: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Therapeutic options for advanced HCC are limited, which is due to a lack of full understanding of pathogenesis. Cel...
Inflammatory proteins are associated with mortality in a middle-aged diverse cohort [0.03%]
炎症蛋白与中年人群死亡率的关系
Nicole Noren Hooten,Nicolle A Mode,Samuel Allotey et al.
Nicole Noren Hooten et al.
Background: Recent data indicate a decline in overall longevity in the United States. Even prior to the COVID-19 pandemic, an increase in midlife mortality rates had been reported. Life expectancy disparities have persist...
IGF2BP3 mediates the mRNA degradation of NF1 to promote triple-negative breast cancer progression via an m6A-dependent manner [0.03%]
IGF2BP3通过m6A依赖的方式介导NF1 mRNA降解以促进三阴性乳腺癌进展
Xu Zhang,Liang Shi,Han-Dong Sun et al.
Xu Zhang et al.
Background: N6-methyladenosine (m6A) is an abundant reversible modification in eukaryotic mRNAs. Emerging evidences indicate that m6A modification plays a vital role in tumourigenesis. As a crucial reader of m6A, IGF2BP3 ...
Rnd3 suppresses endothelial cell pyroptosis in atherosclerosis through regulation of ubiquitination of TRAF6 [0.03%]
Rnd3通过调节TRAF6泛素化抑制动脉粥样硬化中的内皮细胞焦亡
Yan Zhang,Zhengru Zhu,Yang Cao et al.
Yan Zhang et al.
Background: As the main pathological basis for various cardiovascular and cerebrovascular diseases, atherosclerosis has become one of the leading causes of death and disability worldwide. Emerging evidence has suggested t...
Targeted demethylation of the CDO1 promoter based on CRISPR system inhibits the malignant potential of breast cancer cells [0.03%]
基于CRISPR系统的乳腺癌细胞CDO1启动子去甲基化抑制恶性表型的研究
Jiaojiao Yang,Liyue Sun,Xiao-Yun Liu et al.
Jiaojiao Yang et al.
Background: Cysteine dioxygenase 1 (CDO1) is frequently methylated, and its expression is decreased in many human cancers including breast cancer (BC). However, the functional and mechanistic aspects of CDO1 inactivation ...
Uncovering therapeutic opportunities in the clinical development of antibody-drug conjugates [0.03%]
抗体药物偶联物临床开发中的治疗机会探索
Cristina Nieto-Jiménez,Adrián Sanvicente,Cristina Díaz-Tejeiro et al.
Cristina Nieto-Jiménez et al.
Introduction: Antibody-drug conjugates (ADCs) are a family of therapeutic agents that have demonstrated clinical activity in several indications. Material...
Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol-induced articular cartilage degeneration [0.03%]
Circular RNA circARPC1B通过稳定增强波形蛋白发挥功能从而防止高胆固醇诱导的关节软骨退行性变
Jiarui Li,Xiang Li,Shengji Zhou et al.
Jiarui Li et al.
Background: Osteoarthritis (OA) is a prevalent and debilitating condition, that is, directly associated with cholesterol metabolism. Nevertheless, the molecular mechanisms of OA remain largely unknown, and the role of cho...
Neoadjuvant immunotherapy for resectable esophagal squamous cell carcinoma: An ace up the sleeve [0.03%]
可切除食管鳞癌的新辅助免疫治疗：制胜王牌？
Qing Zhou,Jingnan Yuan,Kui Wu et al.
Qing Zhou et al.
Atrial fibrillation hemodynamic effects on lenticulostriate arteries identified at 7-Tesla cerebral magnetic resonance imaging [0.03%]
7特斯拉脑磁共振成像识别的心房颤动的血流动力学作用于豆纹动脉
Andrea Saglietto,Stefania Scarsoglio,Francesco Tripoli et al.
Andrea Saglietto et al.
Non-coding RNAs in cancer immunotherapy: Predictive biomarkers and targets [0.03%]
非编码RNA在癌症免疫治疗中的作用：预测性生物标志物和靶点
Murad Alahdal,Eyad Elkord
Murad Alahdal
Background: To date, standardising clinical predictive biomarkers for assessing the response to immunotherapy remains challenging due to variations in personal genetic signatures, tumour microenvironment complexities and ...