Multi-omics analysis identifies PUS7 as an immune modulator driving NETs-mediated macrophage polarization in pancreatic cancer [0.03%]
多组学分析鉴定出PUS7作为调节NETs介导的巨噬细胞极化的免疫调节因子在胰腺癌中的作用
Jike Fang,Shiye Ruan,Yajie Wang et al.
Jike Fang et al.
Pseudouridine synthases (PUS) have been implicated in various cancers, yet their roles in pancreatic cancer immunity remain unclear. Through integrative multi-omics analyses combining genomics, transcriptomics, and clinical datasets, we eva...
Stimulator of interferon genes (STING)-activating nanomedicines: Translating innate immune modulation into effective therapy for triple-negative breast cancer [0.03%]
干扰素基因刺激剂（STING）激活型纳米药物：将先天免疫调节转化为有效的三阴性乳腺癌疗法
Harshita Singhai,Taha Alqahtani,Humood Al Shmrany et al.
Harshita Singhai et al.
Triple-negative breast cancer (TNBC), marked by profound immunosuppressive complexity, poses a critical challenge in therapy due to the absence of hormone receptors in its phenotype, making it unavailable for conventional therapies. The sti...
HBx hijacks the miR-19a-3p/BAMBI/TGF-β1 axis to impair the anti-tumour activity of CD4+ T cells in diffuse large B-cell lymphoma [0.03%]
HBx通过劫持miR-19a-3p/BAMBI/TGF-β1轴来损害弥漫性大B细胞淋巴瘤中CD4⁺T细胞的抗肿瘤活性
Xuecong Guo,Jianguo Li,Xiaofei Bai et al.
Xuecong Guo et al.
Background: Hepatitis B virus (HBV) is clinically associated with poor prognosis in diffuse large B-cell lymphoma (DLBCL), while cellular communication in the tumour microenvironment (TME) is recognized as a critical driv...
MUC4 mutations promote a thrombotic phenotype in patients with paroxysmal nocturnal haemoglobinuria by increasing the deposition of terminal complement [0.03%]
MUC4突变通过增加末端补体沉积促进阵发性睡眠性血红蛋白尿患者的血栓形成表型
Yingying Chen,Mengting Che,Chaomeng Wang et al.
Yingying Chen et al.
Background: Thrombosis is a common complication in paroxysmal nocturnal haemoglobinuria (PNH) patients, but primary prevention remains controversial. Identifying high-risk individuals could enable risk-stratified prophyla...
Targeting neutrophil-driven immunosuppression: A strategy to overcome immune checkpoint inhibitor resistance [0.03%]
靶向中性粒细胞介导的免疫抑制：克服免疫检查点抑制剂耐药性的策略
Ying Ning,Ke Lei,Xinyan Gao et al.
Ying Ning et al.
Immune checkpoint blockade (ICB) has revolutionized tumour therapy by relieving immunosuppression and restoring effector T cell cytotoxicity. However, its clinical utility is constrained by low response rates and acquired resistance. Tumour...
Feedback regulation between histone H3 lysine 18 lactylation and TROP2-mediated glycolysis drives metastatic progression of colorectal cancer [0.03%]
组蛋白H3赖氨酸18乳酸化与TROP2介导的糖酵解之间的反馈调节驱动结直肠癌转移进展
Weifeng Wang,Yuxiang Deng,Weihao Li et al.
Weifeng Wang et al.
Background: TROP2, a critical cell surface oncogenic signal transducer, is increasingly linked to refractory metastatic colorectal cancer (CRC) and other solid tumours. Robust lactate accumulation within metastatic niches...
Roll with the punches: Fibroblast growth factor 10 alleviates pyroptosis of alveolar epithelial cells in different immune niches [0.03%]
顺势而为：成纤维细胞生长因子10缓解不同免疫微环境中肺泡上皮细胞的焦亡
Tianchang Wei,Xiaoyan Chen,Jian Xu et al.
Tianchang Wei et al.
Background: Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by high mortality with no specific treatments. Fibroblast growth factor 10 (FGF10) is recognized for its tissue repair a...
Fallopian tube lavage sampling towards early detection of pre-invasive ovarian cancer [0.03%]
输卵管冲洗取样术在早期诊断癌前卵巢癌中的应用
Melanie Seaton,Sarah Harbach,Joanne Oke et al.
Melanie Seaton et al.
Melatonin-engineered MSCs-exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival [0.03%]
褪黑素工程MSC来源的外泌体递送USP4稳定ARNTL抑制钟摆式铁死亡以提高皮瓣存活率
Xiaoqiong Jiang,Yu Wang,Xuanlong Zhang et al.
Xiaoqiong Jiang et al.
Background: This study investigates the impact of sleep restriction (SR) on flap viability and its underlying mechanisms. It reveals that SR triggers clock rhythmic ferroptosis, which leads to impaired skin barrier functi...