STK25 inhibits cancer-associated fibroblast activation to overcome cetuximab resistance in colorectal cancer [0.03%]
Yifan Hou,Jiangbo Chen,Hao Hao et al.
Yifan Hou et al.
Background: Cancer-associated fibroblasts (CAFs) within the tumour microenvironment play a pivotal role in colorectal cancer (CRC) progression and therapeutic resistance. Serine/threonine protein kinase 25 (STK25) exerts ...
Single-nucleus RNA sequencing reveals ferroptosis as a potential contributor to the pathogenesis of focal cortical dysplasia [0.03%]
Qingyang Zeng,Fengjun Zhu,Dezhi Cao et al.
Qingyang Zeng et al.
Objective: Focal cortical dysplasia (FCD) is a leading cause of drug-resistant epilepsy, whereas its molecular and cellular mechanisms remain poorly understood. This study aimed to characterize the cellular heterogeneity ...
RNA binding protein ZFP36L1 promotes ferroptosis in chronic rhinosinusitis by destabilizing CAMK2A mRNA and impairing mitochondrial quality control [0.03%]
Jiayi Xiong,Shihan Zhang,Chunhua Li et al.
Jiayi Xiong et al.
Background: RNA-binding proteins (RBPs) and ferroptosis have been demonstrated to play important roles in the progression of chronic rhinosinusitis (CRS). However, the regulatory mechanisms underlying the interaction betw...
Macrophage Cluster of Differentiation 163 promotes post-infarction cardiac repair and preserves left ventricular function via osteopontin [0.03%]
Jingyu Chen,Linjian Chen,Wei Huang et al.
Jingyu Chen et al.
Background: Cardiac macrophages (cMacs) have been implicated in myocardial repair following myocardial infarction (MI), yet their therapeutic potential in ischaemic cardiomyopathy (ICM) remains limited by an incomplete un...
M6A demethylase ALKBH5 mediated Igfbp4 mRNA m6A modification drives fibroblast activation and pathological upper airway fibrosis [0.03%]
ALKBH5介导的Igfbp4 mRNA去甲基化调控成纤维细胞活化和上气道病理纤维化的机制研究
Jing Wang,Ziwei Liao,Mengrou Xu et al.
Jing Wang et al.
Background: Laryngotracheal stenosis (LTS) is a fibroproliferative disease of the upper airway characterised by dysregulated extracellular matrix deposition and fibroblast activation. AlkB Homologue 5 (ALKBH5) has emerged...
Single-cell RNA sequencing and high-dimensional flow cytometry reveal distinct peripheral immune landscapes of type 1 autoimmune pancreatitis and pancreatic ductal adenocarcinoma [0.03%]
单细胞RNA测序和高维流式细胞检测揭示I型自身免疫性胰腺炎和导管细胞癌的外周免疫特点不同
Chenxiao Liu,Tianyi Che,Airu Liu et al.
Chenxiao Liu et al.
Background: Autoimmune pancreatitis (AIP) is a chronic pancreatic inflammatory disease that is often difficult to differentiate from pancreatic cancer. Some AIP patients may even progress into pancreatic ductal adenocarci...
Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis [0.03%]
利用细胞外囊泡生物学进行肾纤维化新型检测和治疗研究
Chin-Ya Sophie Chiang,Andrew J Kassianos,Helen Grania Healy et al.
Chin-Ya Sophie Chiang et al.
Kidney fibrosis is mechanistically characterised by tissue injury followed by development of a fibrogenic niche. The fibrogenic niche involves chronic inflammation, vascular rarefaction, glomerulosclerosis, tubular atrophy, interstitial acc...
Modelling precise responses to anti-seizure medication using brain organoids carrying SCN2A-GoF and SCN2A-LoF mutations [0.03%]
利用携带SCN2A-GoF和SCN2A-LoF突变的脑类器官模拟对抗癫痫药物的精确反应
Yuling Yang,Yi Yan,Yang Cai et al.
Yuling Yang et al.
The landscape of responses to neoadjuvant immunotherapy in resectable Kirsten rat sarcoma viral oncogene homolog-mutant lung adenocarcinoma: Clinical heterogeneity and correlative immunologic analysis [0.03%]
可切除KRAS突变型肺腺癌新辅助免疫治疗的临床异质性和相关免疫学分析：反应图谱
Sikai Wu,Jiheng Niu,Xiaowei Chen et al.
Sikai Wu et al.
Background: Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutant lung adenocarcinoma (LUAD) typically demonstrates limited response to neoadjuvant immunotherapy (NIT). Elucidating the immune determinants that differen...
CD81 promotes proliferation and predicts survival in lung squamous cell carcinoma [0.03%]
CD81促进肺鳞状细胞癌增殖并可作为预后标志物
Ryu Kanzaki,Steven Reid,Paulina Bolivar et al.
Ryu Kanzaki et al.