Prediction of DNA N4-Methylcytosine Sites Based on a Position-Aligned Multi-branch Fusion Network [0.03%]
基于位置对齐多分支融合网络的DNA N4-甲基胞嘧啶位点预测方法
Hangyi Wang,Jian Li,Yaoping Ruan et al.
Hangyi Wang et al.
While DNA N4-methylcytosine (4mC) plays regulatory roles in various organisms, its endogenous presence in mammalian genomes remains debated. Accurate identification of putative 4mC sites in eukaryotic genomes is impeded by scarce validated ...
GxP-Ready Single-Cell RNA-seq and Spatial Transcriptomics End-to-End Pipeline for Clinical Research [0.03%]
符合GxP的单细胞RNA测序和空间转录组学端到端管线用于临床研究
Amaya Zaratiegui,Timothy Burfield,Helle Rus Povlsen et al.
Amaya Zaratiegui et al.
Single-cell/nucleus RNA-sequencing and Spatial Transcriptomics are powerful tools for investigating cellular heterogeneity and tissue architecture that have deepened our disease understanding. Their broader adoption in clinical and regulate...
MiracleNet: A Biologically Interpretable Machine Learning Model for Resected Non-small-cell Lung Cancer [0.03%]
基于切除的非小细胞肺癌的生物可解释机器学习模型 MiracleNet
Rashika Jakhmola,David A Selby,Mert Cihan et al.
Rashika Jakhmola et al.
Lung cancer remains one of the leading causes of cancer-related mortality worldwide. Accurate prediction of relapse is notoriously difficult, posing substantial challenges to patient care and necessitating advanced tools to improve prognost...
Optimizing Histatin 5: Effects of K13 and K17 Substitutions on Proteolytic Stability and Antifungal Activity [0.03%]
优化组蛋白H5：K13和K17替代对蛋白酶稳定性和抗真菌活性的影响
Wright K Makambi,Victoria L Chiu,Lydia Kasper et al.
Wright K Makambi et al.
Human saliva contains a 24-amino acid peptide called histatin 5 (Hst5), which has activity against the fungal pathogen Candida albicans. Degradation of Hst5 by secreted aspartyl proteases (Saps) produced by C. albicans and by salivary prote...
Calibrated Weighted Rank Aggregation for Virtual Screening Independently Rediscovers Privileged Vitamin D Receptor Ligand Scaffolds [0.03%]
基于虚拟筛选的加权排名汇总法可独立发现维生素D受体配体骨架中的特权结构
Abylay Salimzhanov,Askar Boranbayev,Ferdinand Molnár et al.
Abylay Salimzhanov et al.
Computational drug discovery relies on virtual screening to prioritize a small number of compounds for experimental testing, yet combining heterogeneous in silico scoring methods into a single robust ranking remains challenging. We present ...
SLECA: A Single-Cell Atlas of Systemic Lupus Erythematosus Enabling Rare-Cell Discovery Using Graph Transformer [0.03%]
SLECA：利用图变换器进行罕见细胞发现的系统性红斑狼疮单细胞地图集
Maoteng Duan,Yao Shi,Hao Tian et al.
Maoteng Duan et al.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem involvement and marked interpatient heterogeneity. This heterogeneity has hindered precise characterization of the immune dysregulatory mechanisms underlyin...
caRBP-Pred: Leveraging Protein Language Models for the Prediction of Chromatin-Associated RNA-Binding Proteins [0.03%]
caRBP-Pred：利用蛋白质语言模型预测染色质相关RNA结合蛋白
Qiang Sun,Feng Yang,Hao Sun et al.
Qiang Sun et al.
RNA-binding proteins (RBPs) play pivotal roles in cellular processes ranging from RNA metabolism to 3-dimensional genome organization. A distinct subset, chromatin-associated RBPs (caRBPs), binds directly to chromatin to function as transcr...
D81 Mutants Reveal Hidden EF-Tu Diversity while Natural Sequences Preserve Aspartate [0.03%]
D81突变体揭示了隐藏的EF-Tu多样性，而天然序列则保留天冬氨酸
Jordan L Johnson,Yuhong Wang
Jordan L Johnson
Conformational dynamics are central to the function of many proteins, including the translational guanosine triphosphatase EF-Tu. AlphaFold2-based approaches such as AF-Cluster use sequence ensembles to sample alternative conformations, but...
Machine-Learning-Based Prediction of Clinical Outcomes in Gliomas Using Glycomic Features [0.03%]
基于机器学习的胶质瘤临床预后糖组学特征预测
Xin Ma,Derek Allison,Jessica K A Macedo et al.
Xin Ma et al.
Background: Gliomas are primary malignant brain tumors. Among them, grade IV astrocytomas represent the most aggressive form with limited treatment options and a poor prognosis. There is a critical need for reliable prognostic biomarkers to...
Experimental and Mechanistic Validation of PARP1pred for Identifying Potent Leads [0.03%]
PARP1pred的实验和机制验证：鉴定有效先导物的能力
Sermsiri Chitphuk,Wasana Stitchantrakul,Rakkreat Wikiniyadhanee et al.
Sermsiri Chitphuk et al.
Poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) is a pivotal target for treating homologous recombination-deficient cancers through the mechanism of synthetic lethality. While machine learning has accelerated the identification of n...