Integrated Approaches in Drug Repositioning Highlight Ouabain and Helenalin as Potential Drug Candidates for Pulmonary Fibrosis [0.03%]
药物再定位的综合方法揭示了毒毛旋花子苷和 Helenalin 可能是肺纤维化药物候选药物
Zeyad Al-Abdulraheem,Hanna-Kaarina Juppi,Jack Morikka et al.
Zeyad Al-Abdulraheem et al.
New approaches to drug discovery are urgently needed, especially for diseases with complex molecular mechanisms where current treatments show limited efficacy. We present a data-driven workflow for drug repositioning that integrates high-th...
Association between Urinary-Extracellular-Vesicle-Enriched Proteome Dynamics and Oncological Outcomes Following Concurrent Chemoradiation in Locally Advanced Cervical Cancer [0.03%]
同步放化疗后局部晚期宫颈癌患者尿液胞外囊泡富集蛋白组变化及其临床意义
Chutimon Promthong,Raphatphorn Navakanitworakul,Kanokwan Obaun et al.
Chutimon Promthong et al.
Although concurrent chemoradiation (CCRT) is the standard of care for locally advanced cervical cancer, oncological outcomes remain suboptimal. Noninvasive monitoring of treatment responses could improve therapeutic management. This study i...
A Physics-Inspired Approach to Improve Oligonucleotide Design and Gene Synthesis [0.03%]
一种受物理原理启发的寡核苷酸设计及基因合成改进方法
David Luna-Cerralbo,Ana Serrano,Fadi Hamdan et al.
David Luna-Cerralbo et al.
Polymerase cycling assembly (PCA) allows gene synthesis from the assembly of overlapping oligonucleotides. For optimal yield, the sets of overlapping fragments should present uniform hybridization temperatures and minimal spurious dimer for...
A Co-attention Mechanism of Jointly Capturing Sequence and Structure Features for Signal Peptide Prediction [0.03%]
一种联合捕获序列和结构特征的协同注意力机制的信号肽预测方法
Zhixuan Piao,Yuan Liu,Xiaoyong Pan et al.
Zhixuan Piao et al.
Signal peptides are short amino acid sequences at the N-terminus of proteins that serve as subcellular localization signals, directing proteins to specific compartments such as mitochondria, chloroplasts, or the secretory pathway. Although ...
Digital Twin Monitoring System for Chronic Disease Patients: A Simulation-Based Proof of Concept [0.03%]
基于模拟的慢性病患者数字孪生监控系统概念验证研究
Bushra Abbas,Saif Ur Rehman Malik,Munam Ali Shah et al.
Bushra Abbas et al.
The applications of digital twin (DT) technology in healthcare have shown potential to transform patient care. This paper presents a simulation-based proof-of-concept patient digital twin (PDT) for monitoring chronic diseases, namely, hyper...
A Scalable MNase-seq Framework for Reproducible Nucleosome Profiling across Pluripotent Stem Cell and Cardiomyocyte Models [0.03%]
一种可扩展的MNase-seq框架，用于多能干细胞和心肌细胞模型的核小体轮廓图的可重复研究
Chris Thekkedam,David T Humphreys,Marina Naval-Sanchez et al.
Chris Thekkedam et al.
Micrococcal nuclease (MNase) digestion is widely used to profile chromatin accessibility and nucleosome footprinting. However, its application is often limited by sensitivity to reaction conditions, high cell input requirements, and the lac...
Exploring the Binding Specificity of Siglec-Derived Peptides to Human Primary Amine Oxidase Using an Integrative Approach to Ligand Epitope Mapping [0.03%]
采用整合方法对来自Siglec衍生肽的人类主要胺氧化酶配体表位图进行结合特异性研究
Marion Alix,Mikael Londen,Gabriela Guédez et al.
Marion Alix et al.
Human primary amine oxidase (AOC3) is a membrane-anchored protein expressed on the luminal surface of the vascular endothelium at sites of inflammation. It binds via protein-protein interactions to the CE-loops of the C22 domain in Siglec-9...
Deconstructing the Interoperability Stack: A Comparative Technical Analysis of HL7 v2, CDA, and the FHIR Resource Framework [0.03%]
HL7 v2、CDA 和 FHIR 资源框架的互操作性分解：技术比较分析
Vibha Tiwari,Shreecha Jha,Rebakah Geddam et al.
Vibha Tiwari et al.
This structured scoping review aims to provide a technical comparison of the development of interoperability standards in healthcare, from the early electronic health record systems, HL7 v2, HL7 v3/Clinical Document Architecture, to Fast He...
Computational Modeling of Pro-inflammatory Cytokine-Enhanced Blood Coagulation [0.03%]
促炎症细胞因子增强的血液凝固的计算模型
Geli Li,Chen Zhao,Galit H Frydman et al.
Geli Li et al.
The interplay between inflammation and coagulation is a central driver of thrombotic risk across various diseases. While mathematical models of blood coagulation are well established, there remains a critical gap in quantitative frameworks ...
Fractal and Machine Learning Analyses of MALDI-TOF Mass Spectrometry Data in Glioblastoma [0.03%]
基底细胞癌MALDI-TOF质谱数据的分形和机器学习分析
Lucas C Lazari,Ghasem Azemi,Carlo Russo et al.
Lucas C Lazari et al.
Data preprocessing is a critical step in the analysis of matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) spectra for machine learning applications, typically involving steps such as spectra trimmi...