BlendSplice: A Frequency-Blended Generative Framework for In Silico Synthesis of Biologically Realistic Splice Site Sequences [0.03%]
一种频率融合的生成框架，用于合成生物学上真实的剪接位点序列
Espoir Kabanga,Seonil Jee,Arnout Van Messem et al.
Espoir Kabanga et al.
Generative models for biological sequences face challenges in balancing sequence realism with diversity. We investigated whether posttraining frequency blending, combining model-learned distributions with empirical nucleotide priors, can im...
GSCI: A Generative and Sparse Compressed Sensing Imputation Framework for Single-Cell RNA-Sequencing Dropout Recovery [0.03%]
基于生成的单细胞RNA序列滴落恢复的稀疏压缩感知框架(GSCI)
Yan Tian,Meng Li,Bo Han et al.
Yan Tian et al.
Single-cell RNA-sequencing data are inherently sparse and high-dimensional, with dropout events introducing a large number of missing values that hinder downstream analyses. To address the dual challenges of data imputation and dimensionali...
End-to-End Pipeline Integrating Local Small Language Models and Machine Learning for Data Extraction and Stroke Outcome Prediction in Emergency Department [0.03%]
集成局部小型语言模型和机器学习的端到端管道在急诊科进行数据提取和卒中结果预测
Junsu Kim,Ji Hoon Kim,Arom Choi
Junsu Kim
Background: A substantial proportion of clinical data is stored in unstructured text, limiting its utility for evidence generation. Small language models (SLMs) can extract information but face hallucination risks and privacy concerns. Loca...
GenRiskPro: A Comprehensive Whole-Genome Sequencing Analysis Platform for Clinical and Wellness Applications [0.03%]
GenRiskPro：一个临床和健康应用的全面的全基因组测序分析平台
Xiya Song,Xinmeng Liao,Emre Green et al.
Xiya Song et al.
Despite rapid advances in whole-genome sequencing (WGS), translating genomic findings into individualized insights remains challenging. We present GenRiskPro, a clinical decision-support and research platform, which automates WGS variant ca...
The Potential of Digital Twins in Stroke Care: A Systematic Review of Current Applications and Future Perspectives [0.03%]
数字孪生在卒中护理中的潜力：当前应用和未来展望的系统评价
Jawed Nawabi,Semil Eminovic,Dmitriy Desser et al.
Jawed Nawabi et al.
Background: Digital twin technology holds promise for personalized stroke care, but current applications remain fragmented. This systematic review investigates how digital twins are currently utilized in the stroke care continuum. Methods: ...
The Interaction between the Tyrosine Kinase Receptor EphA2 and RNF5: Structural Insights from an In Silico Approach [0.03%]
酪氨酸激酶受体EphA2与RNF5的相互作用：来自计算机模拟方法的结构见解
Marian Vincenzi,Flavia Anna Mercurio,Pasqualina Liana Scognamiglio et al.
Marian Vincenzi et al.
EphA2 is a tyrosine kinase receptor from the Eph (erythropoietin-producing hepatocellular) family that is involved in several processes associated with regular cellular functions, as well as in different pathological conditions including ca...
NCES: A Cell-Specific Network-Augmented Essentiality Framework for Cancer Therapeutic Target Discovery [0.03%]
一种用于癌症治疗靶点发现的基于细胞特异性网络增强必要性分析框架（NCES）
Jinmyung Jung,Sunyong Yoo
Jinmyung Jung
Identifying effective therapeutic targets remains a central challenge in cancer research. CRISPR-Cas9 knockout screens have provided valuable insights into gene essentiality; however, using essentiality at the level of individual genes ofte...
Analyzing DNA Replication Fork Stability and Collapse Using Chromatin Fiber Analysis and the R-ODD-BLOBS Program [0.03%]
利用染色质纤维分析和R-ODD-BLOBS程序分析DNA复制叉的稳定性和崩溃现象
Kerenza Cheng,Kazeera Aliar,Roozbeh Manshaei et al.
Kerenza Cheng et al.
We describe the anatomy of replication forks by detecting proteins associated with DNA replication (Cdc45 and RPA), DNA damage (H2A.X), and DNA repair (Rad51) relative to tracts of synthesized, 5'-bromodeoxyuridine (BrdU)-labeled DNA on chr...
Xu Wang,Baiqing Li,Di Wu et al.
Xu Wang et al.
Exosomes play a crucial role in intercellular communication and disease diagnostics, yet their affinity enrichment remains challenging due to the heterogeneous expression of surface markers. To address this, we engineered a recombinant fusi...
p53 Orchestrates the Immunogenic-Tolerogenic Pyroptosis Switch in Non-Small Cell Lung Cancer: A Systems Biology Approach [0.03%]
系统生物学方法揭示p53在非小细胞肺癌中调控免疫原性-耐受性焦亡转换
Shantanu Gupta,Daner A Silveira,Rodrigo Juliani Siqueira Dalmolin et al.
Shantanu Gupta et al.
Resistance to immunogenic cell death drives therapy failure in non-small cell lung cancer (NSCLC). While the tumor suppressor p53 can activate both canonical (NLRP3-caspase-1-GSDMD) and secondary (caspase-9/3-GSDME) pyroptosis, 2 lytic prog...