Balázs Zoltán Zsidó,Erzsébet Mernyák,Zoltán Kopasz et al.
Balázs Zoltán Zsidó et al.
The rise of rapidly mutating viruses poses growing challenges for drug developers in the fight against antiviral resistance. Viral ion channels generally have low mutation rates and are therefore considered emerging targets for a sustainabl...
Structural and Computational Insights into the Attenuated Innate Immune Recognition of the SARS-CoV-2 N15 Lineage, an Early-Pandemic Variant [0.03%]
SARS-CoV-2 N15谱系结构和计算见解：一种大流行早期变异体的固有免疫识别减弱
Hee Chun Chung,Yoontae Jin,Sung Jae Kim et al.
Hee Chun Chung et al.
Functional diversification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages influences fitness and evasion, yet early-pandemic determinants remain incompletely characterized. In this study, we investigated the molecu...
SARS-CoV-2 NSP8-Derived Peptide Effectively Suppresses the Activity of Helicase NSP13 [0.03%]
SARS-CoV-2 NSP8衍生肽有效抑制解旋酶NSP13活性
Shina Pashova,Peicho Petkov,Rositsa Hristova et al.
Shina Pashova et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 13 (NSP13) is a multifunctional helicase that plays a central role in viral RNA replication and suppression of host innate immunity. Beyond its essential fun...
Theta-Defensin Proteins: Conformational Variability and Environmental Effects [0.03%]
θ-定旋蛋白：构象变异性及环境影响效应研究
Nicolas Vatiliotis,Finn van Loon,Doğa Selin Damar et al.
Nicolas Vatiliotis et al.
Theta-defensins are a unique class of cyclic antimicrobial peptides known for their exceptional structural stability and broad-spectrum antimicrobial activity. Despite their therapeutic potential in mammals, the effects of solvent environme...
From Raw Hospital Records to an AI-Ready Surveillance Dataset: A FAIR-Compliant Data Pipeline for Healthcare-Associated Infection Research in a Chinese District Hospital [0.03%]
从医院原始记录到AI就绪的监测数据集：中国地区医院医疗相关感染研究中符合FAIR标准的数据管道
Dan Han,Xin Shu,Yang Hu et al.
Dan Han et al.
The proliferation of hospital surveillance data in China has not been matched by publicly available, machine-readable datasets suitable for artificial intelligence (AI) research. We describe the design, implementation, and validation of a r...
Classifying Diabetic and Healthy β-Cells in Type 2 Diabetes Using Machine Learning on Single-Cell RNA Sequencing Data [0.03%]
基于单细胞RNA测序数据的机器学习在2型糖尿病中辨别β细胞健康与病变
Daniel F O Onah,María De La Luz Lomboy Toledo
Daniel F O Onah
Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production or function. Two main forms are recognized: type 1 diabetes, which involves the autoimmune destruction of insulin-pro...
Epigenomics-Guided Multi-Omics Integration Uncovers a Lipid-Metabolic Signature with Translational Utility in Bladder Cancer [0.03%]
表观基因组引导的多组学整合发现膀胱癌中具有转化应用价值的脂质代谢标志物
Yu-De Wang,Yo-Liang Lai,Chia-Hsin Liu et al.
Yu-De Wang et al.
Background: Bladder cancer (BLCA) exhibits marked heterogeneity, and current classifiers provide limited guidance for prognosis or treatment. Because epigenetic reprogramming and metabolic rewiring jointly shape BLCA biology, we sought to i...
In Silico Modeling of Nanoparticle Transport across the Blood-Brain Barrier: A Systematic Review [0.03%]
血脑屏障纳米药物传输的体外模拟：系统性综述研究
Qianqian Xia,S H B Herath Mudiyanselage,Sébastien Lafond et al.
Qianqian Xia et al.
Reliable prediction of nanoparticle (NP) transport across the blood-brain barrier (BBB) is essential for designing effective central nervous system-targeted drug delivery systems. The BBB protects the brain but severely restricts the entry ...
Phosphorylation of a Tumor-Derived ASXL2 Epitope Remodels the HLA-Bound Peptide Conformational Ensemble and Interaction Network of the Peptide-HLA Complex [0.03%]
肿瘤衍生的ASXL2磷酸化位点通过重塑肽-HLA复合物的构象和相互作用网络来改变结合肽构象簇状态
Jiahui Zhang,Lin Lv,Bairun Chen et al.
Jiahui Zhang et al.
The expansion of cancer immunotherapy has made it increasingly important to identify tumor-specific human leukocyte antigen (HLA) class I epitopes and to define the molecular determinants of peptide-HLA binding and stability. Posttranslatio...
Structural Modeling of Protein-DNA Interactions Underlying Genome Copy Number Variation in Nanoviruses [0.03%]
纳米病毒基因组拷贝数变异的蛋白质- DNA互作结构模型研究
Aamir Lal,Myeonghwan Kwak,Muhammad Amir Qureshi et al.
Aamir Lal et al.
Multipartite nanoviruses possess multiple segmented genomes that accumulate at unequal levels during infection, giving rise to dynamic genome formulas. Although the replication of all segments relies on a common replication-associated prote...