Pathogen infection-responsive nanoplatform targeting macrophage endoplasmic reticulum for treating life-threatening systemic infection [0.03%]
靶向巨噬细胞内质网的纳米平台用于治疗威胁生命的全身感染
Yan Zhao,Shuo Liu,Zhishang Shi et al.
Yan Zhao et al.
Systemic infections caused by life-threatening pathogens represent one of the main factors leading to clinical death. In this study, we developed a pathogen infection-responsive and macrophage endoplasmic reticulum-targeting nanoplatform to...
Highly sensitive, scalable, and rapid SARS-CoV-2 biosensor based on In2O3 nanoribbon transistors and phosphatase [0.03%]
基于磷atase和In2O3纳米带晶体管的高度灵敏、可扩展和快速的SARS-CoV-2生物传感器
Mingrui Chen,Dingzhou Cui,Zhiyuan Zhao et al.
Mingrui Chen et al.
Developing convenient and accurate SARS-CoV-2 antigen test and serology test is crucial in curbing the global COVID-19 pandemic. In this work, we report an improved indium oxide (In2O3) nanoribbon field-effect transistor (FET) biosensor pla...
Multiple detection of 15 triazine herbicides by gold nanoparticle based-paper sensor [0.03%]
基于金纳米粒子试纸传感器检测15种三嗪类除草剂
Lingling Guo,Xinxin Xu,Jing Zhao et al.
Lingling Guo et al.
Triazine herbicides have been widely used in agriculture, but their residues can harm the environment and human health. To help monitor these, we have developed an effective immunochromatographic strip test that can simultaneously detect 15...
Yuanxin Li,Jing Sun,Jingjing Li et al.
Yuanxin Li et al.
Functional proteins are the most versatile macromolecules. They can be obtained by extraction from natural sources or by genetic engineering technologies. The outstanding selectivity, specificity, binding activity, and biocompatibility endo...
Yongbiao Wan,Kun Chen,Feng Huang et al.
Yongbiao Wan et al.
The volume of securely encrypted data transmission increases continuously in modern society with all things connected. Towards this end, true random numbers generated from physical sources are highly required for guaranteeing security of en...
Emerging systemic delivery strategies of oncolytic viruses: A key step toward cancer immunotherapy [0.03%]
溶瘤病毒的系统递送新策略——迈向肿瘤免疫治疗的重要一步
Weiyue Ban,Jianhuan Guan,Hanwei Huang et al.
Weiyue Ban et al.
Oncolytic virotherapy (OVT) is a novel type of immunotherapy that induces anti-tumor responses through selective self-replication within cancer cells and oncolytic virus (OV)-mediated immunostimulation. Notably, talimogene laherparepvec (T-...
Shao-Hua Zhuo,Jun-Jun Wu,Lang Zhao et al.
Shao-Hua Zhuo et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with several antigenic variants, has grown into a global challenge, and the rapid establishment of an immune barrier is crucial to achieving long-term control of the virus. This ...
Indocyanine green assembled free oxygen-nanobubbles towards enhanced near-infrared induced photodynamic therapy [0.03%]
吲哚菁绿自由氧纳米泡诱导的近红外光动力治疗增强效应研究
Li Yang,Bin Huang,Shiqi Hu et al.
Li Yang et al.
Photodynamic therapy (PDT) has shown a promising capability for cancer treatment with minimal side effects. Indocyanine green (ICG), the only clinically approved near-infrared (NIR) fluorophore, has been used as a photosensitizer for PDT in...
Phytic acid-modified CeO2 as Ca2+ inhibitor for a security reversal of tumor drug resistance [0.03%]
改性的植酸铈纳米颗粒通过抑制钙离子安全逆转肿瘤耐药性
Zhimin Tian,Junlong Zhao,Shoujie Zhao et al.
Zhimin Tian et al.
Ca2+ plays critical roles in the development of diseases, whereas existing various Ca regulation methods have been greatly restricted in their clinical applications due to their high toxicity and inefficiency. To solve this issue, with the ...
Bioengineered pseudovirus nanoparticles displaying the HA1 antigens of influenza viruses for enhanced immunogenicity [0.03%]
呈现流感病毒HA1抗原的生物工程伪病毒纳米颗粒可增强免疫原性
Ming Xia,Md Rejaul Hoq,Pengwei Huang et al.
Ming Xia et al.
Even with implementation of current influenza vaccines, influenza still claims up to 500,000 lives worldwide annually, indicating a need for a better vaccine strategy. We have developed a technology to generate unique S60-HA1 pseudovirus na...