Neda Mohaghegh,Narges Zargar Balajam,Bahareh Hosseinpour et al.
Neda Mohaghegh et al.
Obesity has emerged as a global epidemic, posing severe challenges to public health and contributing to various complications, including metabolic disorders, cardiovascular disease, and type 2 diabetes. This review provides a comprehensive ...
Single-dose cathepsin L CRISPR nanotherapy mitigates PASC-like lung damage in hamsters [0.03%]
单剂量猫科动物组织蛋白酶L CRISPR纳米疗法可减轻恒河猴类长期新冠肺损伤
Zhifen Cui,Tianxiang Liu,Rebecca Bacon et al.
Zhifen Cui et al.
Respiratory post-acute sequelae of COVID-19 (PASC) persists in many SARS-CoV-2 survivors, yet no therapies specifically address its long-term pulmonary damage. We demonstrate that a single-dose CRISPR-CasRx nanotherapy targeting the host en...
Incidental vs. Engineered Nanoparticles in Alzheimer's and Parkinson's Disease: Pathological Pathways and Therapeutic Interventions [0.03%]
阿尔茨海默病和帕金森病中的偶发性纳米颗粒与工程化纳米颗粒：病理途径及治疗干预措施
Hanyu Li,Ning Wang,Xiaobo Mao
Hanyu Li
Nanoparticles (NPs) play dual roles in neurodegeneration. Incidental NPs, generated unintentionally from environmental and industrial sources, are linked to oxidative stress, neuroinflammation, and disruption of the blood-brain barrier in A...
Advances in nanotechnology-enabled adjuvants for peptide-based cancer vaccines [0.03%]
纳米技术助力的肽基癌症疫苗佐剂研究进展
Mengwen Li,Wenpan Li,Zhi Li et al.
Mengwen Li et al.
Peptide-based vaccines only contain peptide epitopes and exclude unnecessary biological materials, which greatly reduces the risk of causing an undesired immune response and further improves the safety profile, garnering considerable intere...
Viral and nonviral nanocarriers for in vivo CRISPR-based gene editing [0.03%]
体内CRISPR基因编辑的病毒和非病毒纳米递送系统
Zhongyuan Guo,Audrey T Zhu,Ronnie H Fang et al.
Zhongyuan Guo et al.
The continued development of clustered regularly interspaced short palindromic repeats (CRISPR) technology has the potential to greatly impact clinical medicine, particularly for disease diagnosis and treatment. Despite high demand for the ...
mRNA medicine: Recent progresses in chemical modification, design, and engineering [0.03%]
mRNA药物研究进展：化学修饰、设计及工程改造
Xiaowen Hou,Jinjun Shi,Yuling Xiao
Xiaowen Hou
Messenger RNA (mRNA) is a type of RNA that carries genetic information from DNA to the ribosome, where it is translated into proteins. mRNA has emerged as a powerful platform for development of new types of medicine, especially after the cl...
LPA1 antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities [0.03%]
LPA1拮抗剂衍生的LNP递送A20 mRNA并促进抗纤维化作用
Jingyue Yan,Diana D Kang,Chang Wang et al.
Jingyue Yan et al.
Activated fibroblasts are major mediators of pulmonary fibrosis. Fibroblasts are generally found in the connective tissue but upon activation can generate excess extracellular matrix (ECM) in the lung interstitial section. Therefore, fibrob...
Materials Advancements for the Safety and Patency of Implantable Cardiovascular Devices [0.03%]
用于植入式心血管装置安全性和通畅性的材料进展
Zulmari Silva Pedraza,Bo Liu,Xudong Wang
Zulmari Silva Pedraza
Implantable cardiovascular devices have revolutionized the management of cardiovascular diseases, significantly enhancing patients' quality of life. With the increasing demand of cardiac implantable electronic devices, the imperative for no...
Facile synthesis of intra-nanogap enhanced Raman tags with different shapes [0.03%]
简易合成具有不同形状的局域增强拉曼标记物
Sanjun Fan,Brian T Scarpitti,Zhewen Luo et al.
Sanjun Fan et al.
Hot spot engineering in plasmonic nanostructures plays a significant role in surface enhanced Raman scattering for bioanalysis and cell imaging. However, creating stable, reproducible, and strong SERS signals remains challenging due to the ...
Zhuhao Wu,Hongwei Cai,Chunhui Tian et al.
Zhuhao Wu et al.
Extracellular vesicles are nano- to microscale, membrane-bound particles released by cells into extracellular space, and act as carriers of biomarkers and therapeutics, holding promising potential in translational medicine. However, the cha...