Metal-organic frameworks based surface-enhanced Raman spectroscopy technique for ultra-sensitive biomedical trace detection [0.03%]
基于金属有机骨架的表面增强拉曼技术用于超灵敏生物医学痕量检测
Yuna Zhang,Cuili Xue,Yuli Xu et al.
Yuna Zhang et al.
Metal-organic frameworks (MOFs) have attracted widespread interest due to their unique and unprecedented advantages in microstructures and properties. Besides, surface-enhanced Raman scattering (SERS) technology has also rapidly developed i...
Amoeba-inspired magnetic microgel assembly assisted by engineered dextran-binding protein for vaccination against life-threatening systemic infection [0.03%]
受变形虫启发的磁性微凝胶集合体通过工程化糊精结合蛋白辅助用于对抗危及生命的全身感染疫苗接种
Shuo Liu,Yan Zhao,Linpei Guo et al.
Shuo Liu et al.
Vaccination is critical for population protection from pathogenic infections. However, its efficiency is frequently compromised by a failure of antigen retention and presentation. Herein, we designed a dextran-binding protein DexBP, which i...
CD137 agonist potentiates the abscopal efficacy of nanoparticle-based photothermal therapy for melanoma [0.03%]
基于纳米粒子的光热治疗介导的CD137激动剂抗黑色素瘤异位效应的研究
Preethi Bala Balakrishnan,Debbie K Ledezma,Juliana Cano-Mejia et al.
Preethi Bala Balakrishnan et al.
Despite the promise of immunotherapy such as the immune checkpoint inhibitors (ICIs) anti-PD-1 and anti-CTLA-4 for advanced melanoma, only 26%-52% of patients respond, and many experience grade III/IV immune-related adverse events. Motivate...
Preparation, applications, and challenges of functional DNA nanomaterials [0.03%]
功能化DNA纳米材料的制备、应用及挑战
Lei Zhang,Mengge Chu,Cailing Ji et al.
Lei Zhang et al.
As a carrier of genetic information, DNA is a versatile module for fabricating nanostructures and nanodevices. Functional molecules could be integrated into DNA by precise base complementary pairing, greatly expanding the functions of DNA n...
Ratiometric fluorescence immunoassay of SARS-CoV-2 nucleocapsid protein via Si-FITC nanoprobe-based inner filter effect [0.03%]
基于Si-FITC纳米探针内滤效应的SARS-CoV-2核衣壳蛋白比值型荧光免疫分析法
Guobin Mao,Yang Yang,Shijie Cao et al.
Guobin Mao et al.
The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has necessitated rapid, easy-to-use, and accurate diagnostic methods to monitor the virus infection. Herein, a ratiometric fluorescence enzyme-...
Single small molecule-assembled nanoparticles mediate efficient oral drug delivery [0.03%]
单一小分子组装的纳米颗粒有效介导口服药物输送
Xin Yang,Chao Ma,Zeming Chen et al.
Xin Yang et al.
Oral drug delivery, which requires surviving the harsh environment in the gastrointestinal (GI) tract and penetrating the intestinal epithelium, has not been achieved using simple formulation nanoparticles (NPs). Medicinal natural products ...
Super-assembly of integrated gold magnetic assay with loop-mediated isothermal amplification for point-of-care testing [0.03%]
基于发夹结构的磁性金纳米颗粒信号放大技术及其在结核分枝杆菌检测中的应用
Jianping Liang,Jie Zeng,Xiaojuan Huang et al.
Jianping Liang et al.
With the increasing global threat of various diseases and infections, it is essential to develop a fast, low-cost, and easy-to-use point-of-care testing (POCT) system for inspections at all levels of medical institutions and self-examinatio...
Cardiomyocyte-targeted anti-inflammatory nanotherapeutics against myocardial ischemia reperfusion (IR) injury [0.03%]
心肌缺血再灌注损伤的抗炎纳米治疗药物开发及应用研究项目
Min Lan,Mengying Hou,Jing Yan et al.
Min Lan et al.
Myocardial ischemia reperfusion (IR) injury is closely related to the overwhelming inflammation in the myocardium. Herein, cardiomyocyte-targeted nanotherapeutics were developed for the reactive oxygen species (ROS)-ultrasensitive co-delive...
Hydroxyapatite nanoparticles drive the potency of Toll-like receptor 9 agonist for amplified innate and adaptive immune response [0.03%]
羟基磷灰石纳米颗粒可增强 toll 样受体 9 激动剂的效力以放大先天性和适应性免疫反应
Qin Zeng,Ruiqi Wang,Yuchen Hua et al.
Qin Zeng et al.
The potency of Toll-like receptor 9 (TLR9) agonist to drive innate immune response was limited due to immune suppression or tolerance during TLR9 signaling activation in immune cells. Herein we addressed this problem by introducing hydroxya...
A biepitope, adjuvant-free, self-assembled influenza nanovaccine provides cross-protection against H3N2 and H1N1 viruses in mice [0.03%]
一种新型流感纳米疫苗具有抗H3N2和H1N1病毒的交叉保护作用
Yongbo Qiao,YaXin Zhang,Jie Chen et al.
Yongbo Qiao et al.
Currently, the incorporation of multiple epitopes into vaccines is more desirable than the incorporation of a single antigen for universal influenza vaccine development. However, epitopes induce poor immune responses. Although the use of ad...