Introduction of graphene oxide-supported multilayer-quantum dots nanofilm into multiplex lateral flow immunoassay: A rapid and ultrasensitive point-of-care testing technique for multiple respiratory viruses [0.03%]
石墨烯氧化物支持的多层量子点纳米膜在多重侧流免疫测定中的应用：一种针对多种呼吸道病毒的快速超灵敏POCT技术
Wenqi Wang,Xingsheng Yang,Zhen Rong et al.
Wenqi Wang et al.
A lateral flow immunoassay (LFA) biosensor that allows the sensitive and accurate identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other common respiratory viruses remains highly desired in the face of the ...
Modeling the gene delivery process of the needle array-based tissue nanotransfection [0.03%]
基于针阵列的组织纳米递送基因过程模型研究
Zhigang Li,Yi Xuan,Subhadip Ghatak et al.
Zhigang Li et al.
Hollow needle array-based tissue nanotransfection (TNT) presents an in vivo transfection approach that directly translocate exogeneous genes to target tissues by using electric pulses. In this work, the gene delivery process of TNT was simu...
Songzi Kou,Weitao Chen,Chenbo Sun et al.
Songzi Kou et al.
The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has wreaked havoc around the globe, with no end in sight. The rapid emergence of viral mutants, marked by rapid transmission and effective immu...
Intracellular and extracellular enzymatic responsive micelle for intelligent therapy of cancer [0.03%]
智能癌症治疗的细胞内和细胞外酶响应性米勒体系统
Dong Wan,Qinan Zhu,Jianxin Zhang et al.
Dong Wan et al.
Recently, the incidence of cancer keeps increasing, seriously endangers human health, and has evolved into the main culprit of human death. Conventional chemotherapeutic drugs, such as paclitaxel and doxorubicin (DOX), have some disadvantag...
Ratiometric fluorescent Si-FITC nanoprobe for immunoassay of SARS-CoV-2 nucleocapsid protein [0.03%]
用于SARS-CoV-2核衣壳蛋白免疫测定的比率荧光Si-FITC纳米探针
Guobin Mao,Silu Ye,Wen Yin et al.
Guobin Mao et al.
Coronavirus disease 2019 (COVID-19) highlights the importance of rapid and reliable diagnostic assays for the management of virus transmission. Here, we developed a one-pot hydrothermal method to prepare Si-FITC nanoparticles (NPs) for the ...
The Yin and Yang of the protein corona on the delivery journey of nanoparticles [0.03%]
纳米颗粒递送旅程中的蛋白质冠的阴阳属性
Yi-Feng Wang,Yaxin Zhou,JiaBei Sun et al.
Yi-Feng Wang et al.
Nanoparticles-based drug delivery systems have attracted significant attention in biomedical fields because they can deliver loaded cargoes to the target site in a controlled manner. However, tremendous challenges must still be overcome to ...
Bing Jiang,Zhanjun Guo,Minmin Liang
Bing Jiang
Single-atom nanozyme (SAzyme) is the hot topic of the current nanozyme research. Its intrinsic properties, such as high activity, stability, and low cost, present great substitutes to natural enzymes. Moreover, its fundamental characteristi...
Probing cell membrane integrity using a histone-targeting protein nanocage displaying precisely positioned fluorophores [0.03%]
利用精准定位荧光团的组蛋白靶向蛋白纳米笼探究细胞膜完整性
Ti Fang,Chaoqun Li,Ao Liang et al.
Ti Fang et al.
Cell membrane integrity is fundamental to the normal activities of cells and is involved in both acute and chronic pathologies. Here, we report a probe for analyzing cell membrane integrity developed from a 9 nm-sized protein nanocage named...
Metal-organic frameworks based surface-enhanced Raman spectroscopy technique for ultra-sensitive biomedical trace detection [0.03%]
基于金属有机骨架的表面增强拉曼技术用于超灵敏生物医学痕量检测
Yuna Zhang,Cuili Xue,Yuli Xu et al.
Yuna Zhang et al.
Metal-organic frameworks (MOFs) have attracted widespread interest due to their unique and unprecedented advantages in microstructures and properties. Besides, surface-enhanced Raman scattering (SERS) technology has also rapidly developed i...
Amoeba-inspired magnetic microgel assembly assisted by engineered dextran-binding protein for vaccination against life-threatening systemic infection [0.03%]
受变形虫启发的磁性微凝胶集合体通过工程化糊精结合蛋白辅助用于对抗危及生命的全身感染疫苗接种
Shuo Liu,Yan Zhao,Linpei Guo et al.
Shuo Liu et al.
Vaccination is critical for population protection from pathogenic infections. However, its efficiency is frequently compromised by a failure of antigen retention and presentation. Herein, we designed a dextran-binding protein DexBP, which i...