Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer's disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay [0.03%]
基于比色和表面增强拉曼散射双读出试纸条的阿尔茨海默病血浆磷酸化Tau超灵敏及现场检测法
Liding Zhang,Ying Su,Xiaohan Liang et al.
Liding Zhang et al.
Phosphorylation of tau at Ser (396, 404) (p-tau396,404) is one of the earliest phosphorylation events, and plasma p-tau396,404 level appears to be a potentially promising biomarker of Alzheimer's disease (AD). The low abundance and easy deg...
Melatonin and probiotics ameliorate nanoplastics-induced hematopoietic injury by modulating the gut microbiota-metabolism [0.03%]
褪黑素和益生菌通过调节肠道微生物群-代谢来缓解纳米塑料引起的造血损伤
Lei Zhang,Jiaru Jing,Lin Han et al.
Lei Zhang et al.
Plastic pollution has become a non-negligible global pollution problem. Nanoplastics (NP) can reach the bone marrow with blood circulation and develop hematotoxicity, but potential mechanisms and prevention strategies are lacking. Here, we ...
Optical control of neuronal activities with photoswitchable nanovesicles [0.03%]
采用光控可逆纳米囊泡光学控制神经元活动
Hejian Xiong,Kevin A Alberto,Jonghae Youn et al.
Hejian Xiong et al.
Precise modulation of neuronal activity by neuroactive molecules is essential for understanding brain circuits and behavior. However, tools for highly controllable molecular release are lacking. Here, we developed a photoswitchable nanovesi...
Self-assembled multiepitope nanovaccine based on NoV P particles induces effective and lasting protection against H3N2 influenza virus [0.03%]
基于诺如病毒P颗粒的自组装多抗原纳米疫苗诱导有效且持久的H3N2流感病毒保护力
Jiaojiao Nie,Qingyu Wang,Shenghui Jin et al.
Jiaojiao Nie et al.
Current seasonal influenza vaccines confer only limited coverage of virus strains due to the frequent genetic and antigenic variability of influenza virus (IV). Epitope vaccines that accurately target conserved domains provide a promising a...
Miniaturized retractable thin-film sensor for wearable multifunctional respiratory monitoring [0.03%]
用于可穿戴多功能呼吸监测的微型可伸缩薄片状传感器
Chengyu Li,Zijie Xu,Shuxing Xu et al.
Chengyu Li et al.
As extremely important physiological indicators, respiratory signals can often reflect or predict the depth and urgency of various diseases. However, designing a wearable respiratory monitoring system with convenience, excellent durability,...
Use of stimulatory responsive soft nanoparticles for intracellular drug delivery [0.03%]
刺激响应性软纳米颗粒在细胞内药物传输中的应用
Krystal A Hughes,Bishal Misra,Maryam Maghareh et al.
Krystal A Hughes et al.
Drug delivery has made tremendous advances in the last decade. Targeted therapies are increasingly common, with intracellular delivery highly impactful and sought after. Intracellular drug delivery systems have limitations due to imprecise ...
pH-triggered cancer-targeting polymers: From extracellular accumulation to intracellular release [0.03%]
pH触发的抗癌靶向聚合物：从细胞外积累到细胞内释放
Rizwan Ullah Khan,Jinning Shao,Jia-Yu Liao et al.
Rizwan Ullah Khan et al.
Stimuli-responsive polymers are promising to achieve targeted delivery, improved stability during circulation, and controlled release of therapeutic and diagnostic agents. Among them, pH-responsive polymeric nanocarriers have attracted sign...
Mengran Guo,Xing Duan,Xingchen Peng et al.
Mengran Guo et al.
Nasopharyngeal carcinoma (NPC) is a serious and highly invasive epithelial malignancy that is closely associated with Epstein-Barr virus (EBV). Due to the lack of therapeutic vaccines for NPC, we selected EBV latent membrane protein 2 (LMP2...
Xiaoyi Ma,Bingbing Liu,Limin Fan et al.
Xiaoyi Ma et al.
Exosomes are extracellular vesicles which carry specific molecular information from donor cells and act as an intercellular communication vehicle, which have emerged as a novel cell-free strategy for the treatment of many diseases including...
Magnetocontrollable droplet mobility on liquid crystal-infused porous surfaces [0.03%]
注入液晶的多孔表面磁控滴液移动性
Yang Xu,Yuxing Yao,Weichen Deng et al.
Yang Xu et al.
Magnetocontrollable droplet mobility on surfaces of both solids and simple fluids have been widely used in a wide range of applications. However, little is understood about the effect of the magnetic field on the wettability and mobility of...