In vivo tumor ultrasound-switchable fluorescence imaging via intravenous injections of size-controlled thermosensitive nanoparticles [0.03%]
基于体内温度响应的智能纳米探针肿瘤声控荧光成像研究
Liqin Ren,Yang Liu,Tingfeng Yao et al.
Liqin Ren et al.
Near-infrared fluorescence imaging has emerged as a noninvasive, inexpensive, and ionizing-radiation-free monitoring tool for assessing tumor growth and treatment efficacy. In particular, ultrasound switchable fluorescence (USF) imaging has...
Valentina Masciotti,Luca Piantanida,Denys Naumenko et al.
Valentina Masciotti et al.
DNA origami is a promising technology for its reproducibility, flexibility, scalability and biocompatibility. Among the several potential applications, DNA origami has been proposed as a tool for drug delivery and as a contrast agent, since...
CRISPR/Cas systems for the detection of nucleic acid and non-nucleic acid targets [0.03%]
用于核酸检测及非核酸靶标的CRISPR/Cas系统
Weiran Su,Junru Li,Chen Ji et al.
Weiran Su et al.
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems are becoming powerful tools for disease biomarkers detection. Due to the specific recognition, cis-cleavage and nonspecific trans-cleavage ca...
Hanxu Chen,Zhiqiang Luo,Xiang Lin et al.
Hanxu Chen et al.
As a promising new micro-physiological system, organ-on-a-chip has been widely utilized for in vitro pharmaceutical study and tissues engineering based on the three-dimensional constructions of tissues/organs and delicate replication of in ...
Engineered protein and Jakinib nanoplatform with extraordinary rheumatoid arthritis treatment [0.03%]
用于治疗关节炎的工程化蛋白及Jak抑制剂纳米递送平台研究
Yuanxin Li,Bo Li,Gang Wang et al.
Yuanxin Li et al.
Rheumatoid arthritis (RA) is a relatively common inflammatory disease that affects the synovial tissue, eventually results in joints destruction and even long-term disability. Although Janus kinase inhibitors (Jakinibs) show a rapid efficac...
CsPbBr3-DMSO merged perovskite micro-bricks for efficient X-ray detection [0.03%]
用于高效X射线检测的CsPbBr3-DMSP混合钙钛矿微砖结构
Tongyu Shi,Wenjun Liu,Jiongtao Zhu et al.
Tongyu Shi et al.
Inorganic perovskite wafers with good stability and adjustable sizes are promising in X-ray detection but the high synthetic temperature is a hindrance. Herein, dimethyl sulfoxide (DMSO) is used to prepare the CsPbBr3 micro-bricks powder at...
Nanotopographic micro-nano forces finely tune the conformation of macrophage mechanosensitive membrane protein integrin β2 to manipulate inflammatory responses [0.03%]
纳米拓扑微纳力精细调节巨噬细胞机械敏感膜蛋白整合素β2构象以调控炎症反应
Yuanlong Guo,Yong Ao,Chen Ye et al.
Yuanlong Guo et al.
Finely tuning mechanosensitive membrane proteins holds great potential in precisely controlling inflammatory responses. In addition to macroscopic force, mechanosensitive membrane proteins are reported to be sensitive to micro-nano forces. ...
Organic thin-film transistors and related devices in life and health monitoring [0.03%]
有机薄膜晶体管及其在生命健康监测中的应用研究进展
Chenfang Sun,Tie Wang
Chenfang Sun
The early determination of disease-related biomarkers can significantly improve the survival rate of patients. Thus, a series of explorations for new diagnosis technologies, such as optical and electrochemical methods, have been devoted to ...
Aerosolized immunotherapeutic nanoparticle inhalation potentiates PD-L1 blockade for locally advanced lung cancer [0.03%]
雾化免疫治疗纳米颗粒吸入可增强PD-L1阻断用于局部晚期肺癌的作用
Yang Liu,William N Crowe,Lulu Wang et al.
Yang Liu et al.
Despite therapeutic advancements, the prognosis of locally advanced non-small cell lung cancer (LANSCLC), which has invaded multiple lobes or the other lung and intrapulmonary lymph nodes, remains poor. The emergence of immunotherapy with i...
Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials [0.03%]
挤压细胞纳米囊泡和外泌体在分子货物和再生潜能方面的比较
Xianyun Wang,Shiqi Hu,Dashuai Zhu et al.
Xianyun Wang et al.
Extracellular vesicles (EVs) generated from mesenchymal stem cells (MSCs) play an essential role in modulating cell-cell communication and tissue regeneration. The clinical translation of EVs is constrained by the poor yield of EVs. Extrusi...