Jackson Travis Del Bonis-O&#x;Donnell,Linda Chio,Gabriel F Dorlhiac et al.
Jackson Travis Del Bonis-O&#x;Donnell et al.
Microscopic imaging of the brain continues to reveal details of its structure, connectivity, and function. To further improve our understanding of the emergent properties and functions of neural circuits, new methods are necessary to direct...
Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins [0.03%]
用于无洗涤剂提取膜蛋白的含脂质双层纳米颗粒的结构分析
Mohammed Jamshad,Vinciane Grimard,Ilaria Idini et al.
Mohammed Jamshad et al.
In the past few years there has been a growth in the use of nano-particles for stabilizing lipid membranes with embedded proteins. These bionanoparticles provide a solution to the challenging problem of membrane protein isolation by maintai...
Qingqing Xiong,Gha Young Lee,Jianxun Ding et al.
Qingqing Xiong et al.
As an attractive alternative to plasmid DNA, messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapeutics for biomedical applications. Advances in addressing the inherent shortcomings of mRNA and in the develo...
DNA-Encoded Morphological Evolution of Bimetallic Pd@Au Core-shell Nanoparticles from a High-indexed Core [0.03%]
高指数晶面对芯的金@钯核壳纳米粒子的DNA编码形态进化
Nitya Sai Reddy Satyavolu,Nikou Pishevaresfahani,Li Huey Tan et al.
Nitya Sai Reddy Satyavolu et al.
DNA-mediated synthesis of nanoparticles with different morphologies has proven to be a powerful method to synthesize and access many exclusive shapes and surface properties. While previous studies employ seeds that contain relatively low-en...
Zhiqiang Luo,Dara E Weiss,Qingyun Liu et al.
Zhiqiang Luo et al.
Bio-integrated materials and devices can blur the interfaces between living and artificial systems. Microfluidics, bioelectronics and engineered nanostructures, with close interactions with biology at the cellular or tissue levels, have alr...
PEGylation of therapeutic oligonucletides: From linear to highly branched PEG architectures [0.03%]
从线性到高度分支的聚乙二醇化治疗性寡核苷酸架构
Xueguang Lu,Ke Zhang
Xueguang Lu
PEGylation, the attachment of poly(ethylene glycol) (PEG), has been adopted to improve the pharmacokinetic properties of oligonucleotide therapeutics for nearly 30 years. Prior efforts mainly focused on the investigation of linear or slight...
Carolina A Ferreira,Dalong Ni,Zachary T Rosenkrans et al.
Carolina A Ferreira et al.
Reactive oxygen and nitrogen species (RONS) are essential for normal physiological processes and play important roles in cell signaling, immunity, and tissue homeostasis. However, excess radical species are implicated in the development and...
General synthesis of silica-based yolk/shell hybrid nanomaterials and in vivo tumor vasculature targeting [0.03%]
基于硅的核壳型复合纳米材料的通用合成及其在体肿瘤血管靶向能力
Feng Chen,Shreya Goel,Sixiang Shi et al.
Feng Chen et al.
Multifunctional yolk/shell-structured hybrid nanomaterials have attracted increasing interest as theranostic nanoplatforms for cancer imaging and therapy. However, because of the lack of suitable surface engineering and tumor targeting stra...
Yang Lu,Ershuai Zhang,Jianhai Yang et al.
Yang Lu et al.
Micelles have been studied as drug delivery carriers for decades. Their use can potentially result in high drug accumulation at the target site through the enhanced permeability and retention effect. Nevertheless, the lack of stability of m...
Nanoscale inhibition of polymorphic and ambidextrous IAPP amyloid aggregation with small molecules [0.03%]
用于抑制多形体和双旋IAPP淀粉样蛋白聚集的的小分子及其纳米级表征研究
Aleksandr Kakinen,Jozef Adamcik,Bo Wang et al.
Aleksandr Kakinen et al.
Understanding how small molecules interface amyloid fibrils on the nanoscale is of importance for developing therapeutic treatment against amyloid-based diseases. Here we show, for the first time, that human islet amyloid polypeptide (IAPP)...