A theranostic agent for cancer therapy and imaging in the second near-infrared window [0.03%]
第二近红外窗口癌症诊疗试剂用于癌症治疗和成像
Zhuoran Ma,Hao Wan,Weizhi Wang et al.
Zhuoran Ma et al.
Theranostic nanoparticles are integrated systems useful for simultaneous diagnosis and imaging guided delivery of therapeutic drugs, with wide ranging potential applications in the clinic. Here we developed a theranostic nanoparticle (~ 24 ...
Advances in targeted nanotherapeutics: From bioconjugation to biomimicry [0.03%]
靶向纳米治疗学的进步：从生物连接到仿生学
Danielle M Valcourt,Jenna Harris,Rachel S Riley et al.
Danielle M Valcourt et al.
Since the emergence of cancer nanomedicine, researchers have had intense interest in developing nanoparticles (NPs) that can specifically target diseased sites while avoiding healthy tissue to mitigate the off-target effects seen with conve...
Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer [0.03%]
用于治疗三阴性乳腺癌的化疗药衍生纳米颗粒包封编码肿瘤抑制蛋白的mRNA
Chengxiang Zhang,Xinfu Zhang,Weiyu Zhao et al.
Chengxiang Zhang et al.
Triple-negative breast cancer (TNBC) is one type of the most aggressive breast cancers with poor prognosis. It is of great urgency to develop new therapeutics for treating TNBC. Based on current treatment guideline and genetic information o...
Xiao Luo,Weiyu Zhao,Bin Li et al.
Xiao Luo et al.
Nanoparticles have been widely explored for combined therapeutic and diagnostic applications. For example, lipid-based nanoparticles have been used to encapsulate multiple types of agents and achieve multi-functions. Herein, we enabled a co...
Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide [0.03%]
石墨烯量子点抢救暴露于人胰岛淀粉样多肽的胰岛β细胞中的蛋白异常调控
Ava Faridi,Yunxiang Sun,Monika Mortimer et al.
Ava Faridi et al.
The amyloid aggregation of peptides and proteins is a hallmark of neurological disorders and type 2 diabetes. Human islet amyloid polypeptide (IAPP), co-secreted with insulin by pancreatic β-cells, plays dual roles in both glycemic control...
Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs [0.03%]
减少纳米颗粒引起的支架结构炎症反应的细胞膜涂层
Zhiyuan Fan,Peter Y Li,Junjie Deng et al.
Zhiyuan Fan et al.
The controlled release of therapeutics from micro or nanoparticles has been well-studied. Incorporation of these particles inside biomaterial scaffolds is promising for tissue regeneration and immune modulation. However, these particles may...
Color-coded perfluorocarbon nanodroplets for multiplexed ultrasound and Photoacoustic imaging [0.03%]
彩色编码的全氟碳纳米液滴用于超声和光声成像中的多重信号检测
Daniela Y Santiesteban,Kristina A Hallam,Steven K Yarmoska et al.
Daniela Y Santiesteban et al.
Laser-activated perfluorocarbon nanodroplets are an emerging class of phase change, dual-contrast agents that can be utilized in ultrasound and photoacoustic imaging. Through the ability to differentiate subpopulations of nanodroplets via l...
Reproducible Large-Scale Synthesis of Surface Silanized Nanoparticles as an Enabling Nanoproteomics Platform: Enrichment of the Human Heart Phosphoproteome [0.03%]
一种用于纳米蛋白质组学平台的富集人心磷蛋白组的可重复的大规模合成表面硅化的纳米颗粒的方法
David S Roberts,Bifan Chen,Timothy N Tiambeng et al.
David S Roberts et al.
A reproducible synthetic strategy was developed for facile large-scale (200 mg) synthesis of surface silanized magnetite (Fe3O4) nanoparticles (NPs) for biological applications. After further coupling a phosphate-specific affinity ligand, t...
Nanoscale Chemical Imaging of Individual, Chemotherapeutic Cytarabine-loaded Liposomal Nanocarriers [0.03%]
单个载有化疗药物阿糖胞苷的脂质纳米载体的纳米级化学成像研究
Karin Wieland,Georg Ramer,Victor U Weiss et al.
Karin Wieland et al.
Dosage of chemotherapeutic drugs is a tradeoff between efficacy and side-effects. Liposomes are nanocarriers that increase therapy efficacy and minimize side-effects by delivering otherwise difficult to administer therapeutics with improved...
Photo-controlled release of paclitaxel and model drugs from RNA pyramids [0.03%]
光控RNA金字塔中包载的紫杉醇及模型药物释放
Congcong Xu,Hui Li,Kaiming Zhang et al.
Congcong Xu et al.
Stimuli-responsive release of drugs from a nanocarrier in spatial-, temporal-, and dosage-controlled fashions is of great interest in the pharmaceutical industry. Paclitaxel is one of the most effective and popular chemotherapeutic drugs ag...