Neurotrophin Receptor Signaling as a Therapeutic Target for Huntington's Disease [0.03%]
神经营养因子受体信号通路作为亨廷顿病的治疗靶点
Danielle A Simmons,Frank M Longo,Stephen M Massa
Danielle A Simmons
Effective non-genetic disease modifying treatments for Huntington's disease (HD) will necessarily target multiple diverse neurodegenerative processes triggered by mutant huntingtin. Neurotrophin receptors are well-positioned for this task a...
Heat Shock Proteins: Old and Novel Roles in Neurodegenerative Diseases in the Central Nervous System [0.03%]
热休克蛋白：中枢神经系统神经退行性疾病中的旧角色与新功能
Johannes M van Noort,Marianna Bugiani,Sandra Amor
Johannes M van Noort
Heat shock proteins (HSPs) are families of molecular chaperones that play important homeostatic functions in the central nervous system (CNS) by preventing protein misfolding, promoting degradation of improperly folded proteins, and protect...
Yudong Zhang,Deepak Ranjan Nayak,Ming Yang et al.
Yudong Zhang et al.
Aim: Sensorineural hearing loss is correlated to massive neurological or psychiatric disease. Materials: T1-weighted volumetric images ...
Xiaoxia Hou,Chuan He,Qingwen Jin et al.
Xiaoxia Hou et al.
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) results from NOTCH3 gene mutations, which lead to the degeneration of vascular smooth muscle cells (VSMCs). ...
Stationary Wavelet Transform and AdaBoost with SVM Based Pathological Brain Detection in MRI Scanning [0.03%]
基于MRI扫描的病理脑检测的平稳小波变换与AdaBoost支持向量机方法
Deepak Ranjan Nayak,Ratnakar Dash,Banshidhar Majhi
Deepak Ranjan Nayak
This paper presents an automatic classification system for segregating pathological brain from normal brains in magnetic resonance imaging scanning. The proposed system employs contrast limited adaptive histogram equalization scheme to enha...
The Differential Diagnosis of Multiple Sclerosis Using Convex Combination of Infinite Kernels [0.03%]
基于无限核凸组合的多发性硬化症鉴别诊断方法研究
Yeliz Karaca,Yu-Dong Zhang,Carlo Cattani et al.
Yeliz Karaca et al.
Our purpose is to develop a clinical decision support system to classify the patients' diagnostics based on features gathered from Magnetic Resonance Imaging (MRI) and Expanded Disability Status Scale (EDSS). We studied 120 patients and 19 ...
Current and Future Perspectives on the Major Depressive Disorder: Focus on the New Multimodal Antidepressant Vortioxetine [0.03%]
当前和未来抑郁症的治疗展望：新型多模式抗抑郁药物沃替西汀值得关注
Laura Orsolini,Carmine Tomasetti,Alessandro Valchera et al.
Laura Orsolini et al.
Background: Vortioxetine (VRX) is a multimodal antidepressant that acts as serotonin (5HT) transporter inhibitor as well as 5HT3A and 5HT7 receptors antagonist, 5HT1A and 5HT1B receptors partial agonist. It was recently a...
A Pathological Brain Detection System based on Extreme Learning Machine Optimized by Bat Algorithm [0.03%]
基于蝙蝠算法优化的极小学习机病理脑识别系统
Siyuan Lu,Xin Qiu,Jianping Shi et al.
Siyuan Lu et al.
Aim: It is beneficial to classify brain images as healthy or pathological automatically, because 3D brain images can generate so much information which is time consuming and tedious for manual analysis. Among various 3D b...
Differentiation of Glioblastoma and Lymphoma Using Feature Extraction and Support Vector Machine [0.03%]
基于特征提取和支持向量机的胶质瘤和淋巴瘤分类方法研究
Zhangjing Yang,Piaopiao Feng,Tian Wen et al.
Zhangjing Yang et al.
Differentiation of glioblastoma multiformes (GBMs) and lymphomas using multi-sequence magnetic resonance imaging (MRI) is an important task that is valuable for treatment planning. However, this task is a challenge because GBMs and lymphoma...
The Positive Synergism of CPT and MK-801 in Behavioral Tests and in Reduction of Environmental Stress and Redox Signaling Changes in Mice Cerebral Cortex [0.03%]
CPT和MK-801在行为学测试中的正向协同作用及其对小鼠大脑皮层环境应力和氧化还原信号变化的减少作用研究
Mariola Herbet,Aleksandra Szopa,Sylwia Wosko et al.
Mariola Herbet et al.
Background: Depressive disorders are associated with oxidative stress. Therefore, it is interesting if antidepressants can affect redox equilibrium and signaling. The first step of our study was to determine the influence...