Endothelial-to-mesenchymal Transition at the Blood-brain Barrier: Molecular Mechanisms and Pathological Roles Across Brain Diseases [0.03%]
血脑屏障内皮细胞向间充质细胞转化：分子机制及在中枢神经系统疾病中的作用
Nur Iffah Ishak,Rosfaiizah Siran,Wan Nor I&#x;zzah Wan Mohamad Zain et al.
Nur Iffah Ishak et al.
Endothelial-to-Mesenchymal Transition (EndMT) is a significant contributor to Blood- Brain Barrier (BBB) dysfunction in various brain diseases. The majority of current therapies, aimed at reducing BBB dysfunction, focus on preventing inflam...
Exosomes in Neurodegenerative Disorders: Isolation Strategies, Therapeutic Potential, and Clinical Trials [0.03%]
外泌体在神经退行性疾病中的研究：隔离策略、治疗潜力及临床试验
Sourin Bhukta,Narahari N Palei,Vishakha Jaiswal et al.
Sourin Bhukta et al.
Exosomes represent a promising class of naturally produced nanoparticles that exist at the nanoscale and carry a negative surface charge under physiological conditions. These tiny membranebound vesicles are released by cells throughout the ...
Zolpidem vs. Emerging Hypnotics: Neuropsychiatric Effects and Ethical Considerations [0.03%]
唑吡坦与新兴催眠药物：神经精神效应及伦理考量
Tawqeer Shafi,Zora Singh,Puja Gulati et al.
Tawqeer Shafi et al.
Introduction: Zolpidem is a widely used non-benzodiazepine hypnotic that is used as a treatment for insomnia due to its rapid onset and perceived safety. Nevertheless, rising clinical reports and post-marketing surveillan...
miR-206-mediated Regulation in Depression: From Pathophysiological Mechanisms to Intranasal AntagomiR-206 Therapy [0.03%]
抑郁症中miR-206介导的调节：从病理生理机制到经鼻抗agomiR-206治疗
Yu-Chi Zhuang,Wei Guan
Yu-Chi Zhuang
Depression is a globally prevalent mental disorder characterized by persistent low mood and cognitive deficits, with high incidence and recurrence rates, causing a heavy burden on individual health and public health systems worldwide. Micro...
Syntaxin-4 at the Crossroads of Synaptic Plasticity and Neurodegeneration: From Molecular Mechanisms to Biomarker and Therapeutic Potential [0.03%]
_syntaxin-4在突触可塑性与神经变性交叉点上的作用：从分子机制到生物标志物和治疗潜力_
Yue Li,YunSong Wei,JingBo Zhao et al.
Yue Li et al.
Syntaxin-4 (Stx4), a member of the Qa-SNARE protein family, is a pivotal regulator of membrane trafficking. Stx4 is predominantly localized at the postsynaptic membrane of neurons and in glial cells, where it is essential for synaptic plast...
Characteristics of Dysphagia Secondary to Ultrasound-guided Botulinum Injections for Cervical Dystonia [0.03%]
颈部肌张力障碍超声引导下肉毒杆菌注射后继发吞咽困难的临床特征分析
Mikhal E Cohen,Yarden Cohen,Alfred Khazen et al.
Mikhal E Cohen et al.
Introduction: Treatment with Botulinum Toxin (BT) is safe and effective. Nonetheless, dysphagia is perhaps the most common side effect of BT injections for Cervical Dystonia (CD). We aimed to characterize the population a...
Gut Microbiota in Neuroinflammation, Neurodegenerative Disorders, and Neuropsychiatric Disorders: A Comprehensive Narrative Review [0.03%]
肠道微生物组在神经炎症、神经退行性疾病和神经精神疾病中的作用：全面叙述性综述
Smita Singh,Sumita Singh,Vishal Khandelwal et al.
Smita Singh et al.
Neurodegenerative and neuropsychiatric illnesses are characterized by neuroinflammation, which is driven by microglial activation, cytokine production, and breakdown of the blood-brain barrier (BBB). It is currently known that the gut micro...
Role of Cholesterol Metabolism in the Link Between Diabetes and Alzheimer's Disease [0.03%]
胆固醇代谢在糖尿病和阿尔茨海默病关联中的作用
Pratishtha Sharma,Rohinee Dodiya,Dipa K Israni et al.
Pratishtha Sharma et al.
Introduction: Type 2 Diabetes Mellitus (T2DM) and Alzheimer's Disease (AD) share complex metabolic disturbances, with cholesterol dysregulation emerging as a central mechanistic link. Although brain cholesterol metabolism...
Linking Neurodegeneration and Age-related Macular Degeneration: Unified Pathways and Intervention Strategies [0.03%]
神经退行性病变和年龄相关性黄斑变性之间的联系：统一的发病机制及干预策略
Shubhangi Mukherjee,Suman Kumar Ray,Sukhes Mukherjee
Shubhangi Mukherjee
Age-related macular degeneration (AMD) is caused by the degeneration of photoreceptors and retinal pigment epithelium (RPE) along with drusen deposition and is the leading cause of vision loss in older adults. Both these structures within t...
Modulating the Microbiota-gut-brain Axis: A Promising Strategy for Alzheimer's Disease Prevention and Management [0.03%]
调控微生物群-肠道-大脑轴：预防和管理阿尔茨海默病的一种有前景的策略
Ritu Kainth,Ajay Singh Kushwah
Ritu Kainth
Alzheimer's disease (AD) is a progressive neurodegenerative disorder evident by cognitive decline and neuropathological hallmarks such as amyloid-β (Aβ) plaques and tau protein hyperphosphorylation. Recent evidence links gut microbiota dy...