Alessandro Martorana
Alessandro Martorana
Amyloid based hypothesis led to develop biomarkers oriented diagnosis of neurodegenerative dementias. Among them biomarkers for AD, the most diffuse form of dementia, are currently the unique available for scientific and diagnostic purposes...
Increase Signaling of Wnt/β-Catenin Pathway and Presence of Apoptosis in Cerebellum of Kindled Rats [0.03%]
kindled大鼠小脑Wnt/β-catenin信号上调及凋亡现象的研究
Carmen Rubio,Artemio Rosiles-Abonce,Cristina Trejo-Solis et al.
Carmen Rubio et al.
Background: Epilepsy is one of the most common neurological disorders in humans, and the role of the cerebellum in its physiopathology remains the subject of study. The Purkinje cells (PC), whose axons target the dentate ...
The Interplay between Cofilin and Phospho-Cofilin: Its Role in Maintaining Blood Brain Barrier Integrity [0.03%]
扭动蛋白与磷酸化扭动蛋白之间的相互作用对维持血脑屏障完整性的功能研究
Qasim Alhadidi,Muhammad Shahdaat Bin Sayeed,Zahoor A Shah
Qasim Alhadidi
The blood brain barrier (BBB) is a continuous, non-fenestrated vessel system that tightly regulates the movement of molecules, ions, and cells between the blood and the central nervous system. Endothelial cells are the major constituents of...
Brain Tumor Segmentation Using Deep Belief Networks and Pathological Knowledge [0.03%]
基于深度信念网络和病理知识的脑肿瘤分割
Tianming Zhan,Yi Chen,Xunning Hong et al.
Tianming Zhan et al.
In this paper, we propose an automatic brain tumor segmentation method based on Deep Belief Networks (DBNs) and pathological knowledge. The proposed method is targeted against gliomas (both low and high grade) obtained in multi-sequence mag...
Advanced Structure-activity Relationships Applied to Mentha spicata L. Subsp. spicata Essential Oil Compounds as AChE and NMDA Ligands, in Comparison with Donepezil, Galantamine and Memantine - New Approach in Brain Disorders Pharmacology [0.03%]
基于脑病药物研发的新型留兰香化学成分的高级构效关系及其与多奈哌齐、石南素和氨己烯酸的对比研究
Speranta Avram,Maria Mernea,Eyup Bagci et al.
Speranta Avram et al.
Background: Alzheimer's disease (AD) therapy is based on several natural and synthetic compounds that act as acetylcholinesterase (AChE) and N-methyl-D-aspartate receptor (NMDA) ligands that have limited efficiency in rel...
Stephen D Skaper,Laura Facci,Morena Zusso et al.
Stephen D Skaper et al.
Neuroplasticity is not only shaped by learning and memory but is also a mediator of responses to neuron attrition and injury (compensatory plasticity). As an ongoing process it reacts to neuronal cell activity and injury, death, and genesis...
Preventive and Protective Roles of Dietary Nrf2 Activators Against Central Nervous System Diseases [0.03%]
饮食型Nrf2激活剂预防中枢神经系统疾病的作用机制研究
Yang Sun,Tuo Yang,Rehana K Leak et al.
Yang Sun et al.
Central nervous system diseases are major health issues and are often associated with disability or death. Most central nervous system disorders are characterized by high levels of oxidative stress. Nuclear factor erythroid 2 related factor...
Axotomy Leads to Reduced Calcium Increase and Earlier Termination of CCL2 Release in Spinal Motoneurons with Upregulated Parvalbumin Followed by Decreased Neighboring Microglial Activation [0.03%]
轴突切断导致脊髓运动神经元中CCL2释放减少和持续时间缩短，伴有钙离子增加减弱和_parvalbumin上调，随后导致邻近的小胶质细胞活化降低
Melinda Paizs,Roland Patai,Jozsef I Engelhardt et al.
Melinda Paizs et al.
Background: Motoneurons with naturally elevated calcium binding protein content, such as parvalbumin, are more resistant against injury. Furthermore, increase of intracellular calcium, which plays a pivotal role in injury...
Exercise Induced Neuroplasticity to Enhance Therapeutic Outcomes of Cognitive Remediation in Schizophrenia: Analyzing the Role of Brai nderived Neurotrophic Factor [0.03%]
运动诱导的神经可塑性在精神分裂症认知康复治疗中的作用及脑源性神经营养因子的作用分析
Carlos Campos,Nuno B F Rocha,Eduardo Lattari et al.
Carlos Campos et al.
Background: Cognitive impairment is a major manifestation of schizophrenia and a crucial treatment target as these deficits are closely related to patients' functional outcomes. Cognitive remediation is the gold-standard ...
Coarse Classification to Region-Scalable Refining for White Matter Lesions Segmentation in Multi-Channel MRI [0.03%]
多模态MRI下脑白质病变粗分类与区域可变精修正分割
Renping Yu,Liang Xiao,Zhihui Wei
Renping Yu
Brain lesions, especially White Matter Lesions (WMLs) that mostly found on magnetic resonance images of elderly people, are not only associated with normal aging, but also with various geriatric disorders including cardiovascular diseases, ...