Demonstration of Biological and Immunological Equivalence of a Generic Glatiramer Acetate [0.03%]
醋酸格拉替雷仿制药的生物及免疫等效性验证试验报告摘要
Josephine D Alessandro,Kevin Garofalo,Ganlin Zhao et al.
Josephine D Alessandro et al.
Background: In April 2015, the US Food and Drug Administration approved the first generic glatiramer acetate, Glatopa® (M356), as fully substitutable for Copaxone® 20 mg/mL for relapsing forms of multiple sclerosis (MS)...
Suicide Prevention in Schizophrenia: Do Long-Acting Injectable Antipsychotics (LAIs) have a Role? [0.03%]
长效抗精神病药物(LAIs)在精神分裂症自杀预防中的作用？
Maurizio Pompili,Laura Orsolini,Dorian A Lamis et al.
Maurizio Pompili et al.
Suicide risk is a major cause of death among patients with schizophrenia. Death by suicide has been reported in approximately 5% of schizophrenia patients although this figure appears to be an underestimate of the problem. A number of risk ...
Parkinson's Disease is Accompanied by Intertwined Alterations in Iron Metabolism and Activated Immune-inflammatory and Oxidative Stress Pathways [0.03%]
帕金森病铁代谢、免疫炎症和氧化应激途径的变化互相交织
Carine Coneglian de Farias,Michael Maes,Kamila Landucci Bonifacio et al.
Carine Coneglian de Farias et al.
Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by a complex interplay between peripheral and central inflammatory and oxidative stress pathways. ...
The Endocannabinoid System Modulating Levels of Consciousness, Emotions and Likely Dream Contents [0.03%]
内源大麻素系统调节意识水平、情绪及可能做梦的内容
Eric Murillo-Rodriguez,Jose Carlos Pastrana-Trejo,Mireille Salas-Crisóstomo et al.
Eric Murillo-Rodriguez et al.
Background & objective: Cannabinoids are derivatives that are either compounds occurring naturally in the plant, Cannabis sativa or synthetic analogs of these molecules. The first and most widely investigated of the canna...
Granulocyte Colony-Stimulating Factor Attenuates Blood-Brain Barrier Damage and Improves Cognitive Function in Spontaneously Hypertensive Rats [0.03%]
粒细胞集落刺激因子减轻自发性高血压大鼠血脑屏障损害及改善认知功能
Xin Wei,Yan Xu,Yanling Jin et al.
Xin Wei et al.
Background: Cerebral small vessel diseases (CSVDs) always coincide with endothelial dysfunction and blood-brain barrier (BBB) damage. However, the detailed mechanisms of CSVD are still unclear and the therapeutic efficacy...
GABAA Receptors as Targets for the Management of Pain-related Disorders: Historical Perspective and Update [0.03%]
镇痛相关疾病的GABA受体靶点：历史视角与最新研究进展
Bradford D Fischer
Bradford D Fischer
Background: Chronic pain is treated most commonly with opioid analgesics, anti-inflammatory steroids and nonsteroidal anti-inflammatory drugs. Method: ...
Inhibition of Butyrylcholinesterase with Fluorobenzylcymserine, An Experimental Alzheimer's Drug Candidate: Validation of Enzoinformatics Results by Classical and Innovative Enzyme Kinetic Analyses [0.03%]
通过经典和创新的酶动力学分析验证乙胩基胆碱酯酶与 fluorobenzylcyserase（一种实验性的阿尔茨海默症药物）结合的抑制作用：基于酶信息学结果的验证
Mohammad A Kamal,Shazi Shakil,Muhammad S Nawaz et al.
Mohammad A Kamal et al.
Background: Selective butyrylcholinesterase (BuChE)-inhibition, increases acetylcholine (ACh) levels. In rodents, this inhibition is known to boost cognition. Also, this occurs without the typical unwanted adverse effects...
The TLR9 Antagonist iCpG-ODN at Different Dosages Inhibits Cerebral Ischemia/Reperfusion Injury in Mice [0.03%]
不同剂量的TLR9拮抗剂iCpG-ODN抑制小鼠脑缺血再灌注损伤
Ying Zhou,Jingrui Pan,Qingxia Peng et al.
Ying Zhou et al.
Background: Inflammatory responses are important mechanisms that are involved in cerebral ischemia/reperfusion(I/R) injury. Whether toll-like receptor 9(TLR9), which belongs to the innate immune system, takes part in the ...
Livia Dezsi,Laszlo Vecsei
Livia Dezsi
Background: Parkinson's disease (PD) is a neurodegenerative disorder with a prevalence increasing with age. Oxidative stress and glutamate toxicity are involved in its pathomechanism. There are still many unmet needs of P...
The Effect of Pyrroloquinoline Quinone on Apoptosis and Autophagy in Traumatic Brain Injury [0.03%]
吡咯喹啉醌对创伤性脑损伤后细胞凋亡及自噬的影响
Pengju Zhang,Yongqi Ye,Yuhang Qian et al.
Pengju Zhang et al.
Background: Pyrroloquinoline quinone is an anionic, water-soluble compound with antioxidant characteristic. The role of pyrroloquinoline quinone in pharmacology and nutrition has attracted wide attention of researchers. A...