Cannabis; Epidemiological, Neurobiological and Psychopathological Issues: An Update [0.03%]
大麻；流行病学、神经生物学和心理病理学问题：最新研究进展
Maria Antonietta De Luca,Gaetano Di Chiara,Cristina Cadoni et al.
Maria Antonietta De Luca et al.
Background: Cannabis is the illicit drug with both the largest current levels of consumption and the highest reported lifetime prevalence levels in the world. Across different countries, the prevalence of cannabis use var...
IgA/IgM Responses to Gram-Negative Bacteria are not Associated with Perinatal Depression, but with Physio-somatic Symptoms and Activation of the Tryptophan Catabolite Pathway at the End of Term and Postnatal Anxiety [0.03%]
IgA/IgM对Gram阴性菌的反应与围产期抑郁无关，但与分娩前后躯体症状及激活吲哚胺2,3双加氧酶通路相关
Chutima Roomruangwong,Buranee Kanchanatawan,Sunee Sirivichayakul et al.
Chutima Roomruangwong et al.
Background: Evidence has implicated the translocation of commensal Gram-negative bacteria (Gram-B) due to leaky gut in the pathophysiology of depression and physio-somatic symptoms (e.g. fatigue, pain, irritable bowel syn...
Elevated C-reactive Protein Levels in Women with Bipolar Disorder may be Explained by a History of Childhood Trauma, Especially Sexual Abuse, Body Mass Index and Age [0.03%]
女性双相障碍患者C-反应蛋白升高的原因是童年虐待史（特别是性虐待）、体质指数和年龄所致
Juliana Brum Moraes,Michael Maes,Decio Sabbatini Barbosa et al.
Juliana Brum Moraes et al.
Objective and background: To evaluate whether increased levels of high-sensitivity C- reactive protein (hs-CRP) observed in individuals with bipolar disorder (BD) compared to healthy controls (HCs) could be influenced by ...
Immune System Modulators with Antidepressant Effects: Evidence from Animal Models [0.03%]
具有抗抑郁作用的免疫系统调节剂：来自动物模型的证据
Helena M Abelaira,Amanda L Maciel,Joao Quevedo et al.
Helena M Abelaira et al.
Background: Major depressive disorder (MDD) is associated with high mortality and morbidity rates, and currently, approximately 340 million people worldwide suffer from depression at some point in life. In view of the gro...
Therapeutic Role of Synaptic Vesicle Glycoprotein 2A (SV2A) in Modulating Epileptogenesis [0.03%]
突触囊泡糖蛋白2A(SV2A)在癫痫发病机制中的治疗作用
Yukihiro Ohno,Kentaro Tokudome
Yukihiro Ohno
Dysfunction of synaptic neurotransmitter release is closely involved in the pathogenesis of various central nervous system diseases. Synaptic vesicle glycoprotein 2A (SV2A) is a membrane protein specifically expressed in synaptic vesicles a...
Ultra-micronized Palmitoylethanolamide: An Efficacious Adjuvant Therapy for Parkinson's Disease [0.03%]
超微米棕榈酰乙醇胺：帕金森病的有效辅助治疗药物
Stefania Brotini,Carlo Schievano,Leonello Guidi
Stefania Brotini
Background: Parkinson's disease (PD) is the subject of intense efforts to develop strategies that slow down or stop disease progression and disability. Substantial evidence points to a prominent role for neuroinflammation...
Observational Study
CNS & neurological disorders drug targets. 2017;16(6):705-713. DOI:10.2174/1871527316666170321124949 2017
Andrea Herrera-Solis,Wendy Herrera-Morales,Luis Nunez-Jaramillo et al.
Andrea Herrera-Solis et al.
The role of dopamine in sleep-wake regulation is considered as a wakefulness-promoting agent. For the clinical treatment of excessive daytime sleepiness, drugs have been commonly used to increase dopamine release. However, sleep disorders o...
Utilizing Delta Opioid Receptors and Peptides for Cytoprotection: Implications in Stroke and Other Neurological Disorders [0.03%]
利用δ型阿片受体和多肽进行细胞保护：中风及其他神经疾病的启示
Marci G Crowley,M Grant Liska,Trenton Lippert et al.
Marci G Crowley et al.
The opioid system has been elucidated as a potential target for therapy in a variety of neurological disorders including stroke. Delta opioid receptors have been revealed to pose an especially compelling biological function for new neuropro...
Further Evaluation of Mechanisms Associated with the Antidepressantlike Signature of Scopolamine in Mice [0.03%]
评估Scopolamine的抗抑郁特性在小鼠中的相关机制进一步研究
Anna E Martin,Douglas A Schober,Alexander Nikolayev et al.
Anna E Martin et al.
Background: Conventional antidepressants lack efficacy for many patients (treatmentresistant depression or TRD) and generally take weeks to produce full therapeutic response in others. Emerging data has identified certain...
Filippo Caraci,Janet Sultana,Filippo Drago et al.
Filippo Caraci et al.
Background: The aging world population had led to an increase in the prevalence of Alzheimer's disease (AD). The drugs used to slow down the onset of AD, galantamine, donepezil, rivastigmine and memantine, are generally w...