Ananya Misra,Arya Solanki,Prachi Sahu et al.
Ananya Misra et al.
Migraine is the most prevalent neurological condition, which affects 1.16 million individuals globally, ranking first among adolescents and children and second in the case of adults aged under 60 years. Both genetic and environmental factor...
Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and Targeted Therapeutics [0.03%]
精准神经退行性疾病：分子机制、生物标志物和靶向治疗的整合
Guizhen Lyu,Dongbing Li
Guizhen Lyu
Neurodegenerative diseases (NDDs) such as Alzheimer's, Parkinson's and related tauopathies are converging pathologies driven by protein misfolding, maladaptive microglial responses, epigenetic dysregulation and metabolic failure. Here we sy...
A Systematic Review of Recent Advances in Drug Delivery to the Central Nervous System Through Prodrug Approach [0.03%]
前药方法用于中枢神经系统药物递送的近期进展综述
Sara Burhan Ahmed,Narmin Hamaamin Hussen,Aso Hameed Hasan et al.
Sara Burhan Ahmed et al.
Introduction: Central nervous system disease is one of the significant threats to human health worldwide, affecting both the physical and mental health of the patient. However, designing drugs for the central nervous syst...
Aashmi Choudhary,Maneesh Mohan,Ashi Mannan et al.
Aashmi Choudhary et al.
Neuroinflammation refers to the inflammation of the brain and spinal cord, which can lead to anxiety disorders. Studies show that pro-inflammatory cytokines like IL-6, TNF-α, and IL-β disrupt normal brain function and promote anxiety-like...
Recent Updates on Lipid Landscapes in Neonatal and Adult Neurological Disorders: Advancing Mass Spectrometry and Lipidomics for Disease Insight: A Systematic Review [0.03%]
新生儿和成人神经疾病中的脂质景观最新研究进展：推进质谱及脂质组学以洞察疾病：系统性综述
Santosh Kapil Kumar Gorti,Dilip Kumar Reddy,Hemanth Vikram Pr et al.
Santosh Kapil Kumar Gorti et al.
The brain's complexity arises from intricate neural circuitry and dynamic molecular interactions. While genomics and proteomics have expanded understanding of brain pathology, lipidomics- particularly through metabolite and membrane lipid p...
Protective Effects of Memantine Against Acute Stress-Induced Fear Memory and Synaptic Dysfunction via NMDA Receptor Antagonism [0.03%]
氨磺必利通过抗N-甲基-D天冬氨酸受体作用对抗急性应激源所致的恐惧记忆和突触损伤现象中的保护效应研究
Sumadhura Bommaraju,Mrunali D Dhokne,Patel Parthkumar Rakeshkumar et al.
Sumadhura Bommaraju et al.
Introduction: Post-traumatic stress disorder (PTSD) is a complex mental health condition that arises following exposure to severe psychological trauma. Dysregulation of excitatory transmission, especially involving N-meth...
Pharmacological Breakthroughs with Extracellular Vesicles-Based Nanomedicine: A Targeted Strategy to Cross the Blood-Brain Barrier in Alzheimer's Disease [0.03%]
基于外泌体的纳米药物在阿尔茨海默病中的药理学突破：跨越血脑屏障的靶向策略
Jasmeen Kaur,Dushyant,Smita Narwal et al.
Jasmeen Kaur et al.
Alzheimer's Disease (AD) is a disabling neurodegenerative illness characterized by Amyloid-beta (Aβ) plaque deposition, tau tangles, and neuroinflammation. These pathological characteristics lead to progressive cognitive decline, and drug ...
John Ihayi Ogbu,Thysia Mendes Rosa,Antônio Sérgio Nakao de Aguiar et al.
John Ihayi Ogbu et al.
Epilepsy remains a global challenge, with about one-third of affected patients being resistant to treatment. Seizures and motor abnormalities characterized by movement difficulties are common in epilepsy, highlighting the need for treatment...
Synergistic Roles of Neuropeptide S and Environmental Enrichment in Preclinical Huntington's Disease Depression Models [0.03%]
神经肽S和环境丰富度在临床前亨廷顿舞蹈病抑郁模型中的协同作用
Ganesh Rahangdale,Krishna R Gupta,Milind J Ume
Ganesh Rahangdale
Introduction: Huntington's disease (HD) is a progressive neurodegenerative disorder marked by motor, cognitive, and psychiatric impairments, with depression as a major comorbidity. Existing treatments for Huntington-relat...
Microbiota-Gut-Brain Axis: A Novel Paradigm in the Neurobiology of Anxiety [0.03%]
微生态-肠-脑轴在焦虑神经生物学中的新范式
Ayushi Goel,Saumya Das,Avijit Mazumder et al.
Ayushi Goel et al.
Introduction: The gut microbiome and the central nervous system are intricately connected through a bidirectional communication system that plays a vital role in maintaining gut homeostasis and overall health. Disruptions...