Neuroinflammation, Autophagy, and Neurodegeneration: Mechanisms and Therapeutic Insights [0.03%]
神经炎症、自噬和神经退行性病变：机制和治疗见解
Pukar Khanal,Abhishek Balmik
Pukar Khanal
Neuroinflammation and autophagy dysregulation are critical in the pathogenesis of neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's disease. Neuroinflammation occurs after a sustained immune response, which transiti...
Acute Effects of High-Intensity Interval Training (HIIT) on Heart Rate Variability and Psychoaffective Responses Among Bipolar Patients and their Control Peers: A Randomized Crossover Trial [0.03%]
高强度间歇训练（HIIT）对双相患者及其对照组的心率变异性及心理情感反应的急性影响：一项随机交叉试验
Alberto Souza Sá Filho,Marcelo Magalhães Sales,Pedro Augusto Inacio et al.
Alberto Souza Sá Filho et al.
Introduction: to evaluate the acute effects of continuous moderate-intensity aerobic exercise and high-intensity interval training (HIIT) on heart rate variability (HRV) and psychoaffective responses in patients with bipo...
Reconnoitering the Potential of the Pharmacogenomics Approach in the Management of Alzheimer's Disease: A Review [0.03%]
阿尔茨海默病管理中药物基因组学方法潜力探究：综述文章
Dipak S Thorat,Md Jamir Uddin,Rashid Ismael Hag Ibrahim et al.
Dipak S Thorat et al.
Alzheimer's disease (AD) is a neurological disorder that affects adults worldwide. AD is also an essential geriatric disorder because of its significant emotional and economic impact on individuals, their loved ones, and society. Traditiona...
Breaking Barriers: Advanced Pharmacological Mediators for Neuropsychiatric Disorders [0.03%]
突破障碍：神经精神疾病高级药理介导器
Tapas Kumar Mohapatra,Atul R Bendale,Tara Shankar Basuri et al.
Tapas Kumar Mohapatra et al.
Neuropsychiatric disorders include bipolar disorder, schizophrenia, and major depression. They present significant challenges to clinical management due to their complex pathophysiology and diverse symptomatology. Despite advancements in ps...
Immune Cell Infiltration and Key Gene Identification in Alzheimer's Disease and Sleep Deprivation [0.03%]
阿尔茨海默病和睡眠剥夺相关的免疫细胞浸润及关键基因识别
Liang Yanchao,Li Yuchen,Xiang Huan et al.
Liang Yanchao et al.
Introduction: Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by Amyloid-β plaques and neurofibrillary tangles. Disrupted circadian rhythms are common in AD and may worsen cognitive decline an...
Cyclodextrins-Phospholipids Complex Loaded Nanofibers for Improved Oral Bioavailability and Brain Targeting for Management of Stress and Anxiety [0.03%]
用于改善口服生物利用度和脑靶向以管理和焦虑的 Cyclodextrin-磷脂复合纳米纤维
Iqra Zai,Nazeer Hasan,Mohd Aqil et al.
Iqra Zai et al.
Depression and anxiety have emerged as significant public health concerns worldwide, with conventional pharmacotherapy often limited by poor solubility, low bioavailability, and suboptimal brain targeting of therapeutic agents. To address t...
Targeting Dopaminergic Pathways: Current and Emerging Dopamine Inhibitors in Neurological and Psychiatric Disorders [0.03%]
多巴胺通路的靶向作用：神经和精神障碍中当前及新兴的多巴胺抑制剂
Gulsah Yildiz Deniz
Gulsah Yildiz Deniz
Dopaminergic signaling plays a central role in regulating motor control, reward processing, and emotional balance. Dysregulation of dopamine pathways is implicated in multiple neuropsychiatric disorders. This review primarily focuses on cur...
Synergistic Neuroimmune Modulation by Cannabidiol and Probiotics for Therapeutic Advancement in CNS Disorders: A Systematic Review [0.03%]
大麻二酚和益生菌在中枢神经系统疾病治疗中的协同神经免疫调节作用：系统评价
Shikha Baghel Chauhan,Dhruv Pratap SIngh Jaitawat,Chirag Jain et al.
Shikha Baghel Chauhan et al.
Introduction: The gut-brain axis (GBA) is a complex, bidirectional communication network connecting the gastrointestinal tract and central nervous system. Cannabidiol (CBD) and probiotics have shown promising neuroprotect...
Neuroprotective Impact of Magnesium Sulfate on Mortality in Sepsis-Associated Encephalopathy: A Propensity-Matched Analysis of Medical Information Mart for Intensive Care IV Database [0.03%]
硫酸镁对脓毒症相关性脑病患者院内死亡的保护作用：来自医学信息集束化治疗IV数据库的事后倾向匹配分析
Wenchao Mao,Changqin Chen,Xinle Lai et al.
Wenchao Mao et al.
Introduction: This study aimed to evaluate the association between magnesium sulfate and mortality in patients with Sepsis-Associated Encephalopathy (SAE), given the lack of established therapies and emerging evidence of ...
Strategic Neurodelivery of Psychedelic Compounds: Bridging Molecular Pharmacology with Therapeutic Innovation in CNS Disorders [0.03%]
战略性神经传递迷幻化合物：在中枢神经系统疾病治疗创新中连接分子药理学桥梁
Shikha Baghel Chauhan,Naziya Akhtar,Chirag Jain et al.
Shikha Baghel Chauhan et al.
Psychedelic compounds such as psilocybin, Lysergic Acid Diethylamide (LSD), N,Ndimethyltryptamine (DMT), and 3,4-methylenedioxymethamphetamine (MDMA) are emerging as novel therapeutics for neuropsychiatric disorders, including depression, P...