Focused Ultrasound-activated Extracellular Vesicles-nanoparticle Hybrids for Targeted Brain Drug Delivery: Engineering Strategies and Translational Outlook [0.03%]
聚焦超声激活的细胞外囊泡-纳米粒子杂化物用于靶向脑药物递送：工程策略与转化前景
Yash Kalra,Shikha Baghel Chauhan,Indu Singh et al.
Yash Kalra et al.
A revolutionary method for targeted neurotherapeutics is focused ultrasound (FUS)-mediated blood-brain barrier (BBB) regulation. In order to enable controlled and targeted intracerebral drug delivery, recent developments in hybrid extracell...
Multi-Target Mechanisms of Ginsenosides in Spinal Cord Injury: A Systematic Review of Preclinical Evidence [0.03%]
人参皂苷在脊髓损伤中的多靶点机制：临床前证据的系统评价
Yimin Yang,Jianxing Guo,Guowei Ye et al.
Yimin Yang et al.
Spinal cord injury (SCI) leads to severe sensory, motor, and autonomic dysfunction with limited treatment options. Ginsenosides, the primary bioactive compounds derived from Panax ginseng, have demonstrated neuroprotective potential in SCI....
AI-Driven Biomarker Discovery in Motor-Related Neurodegenerative Diseases [0.03%]
人工智能在运动功能相关神经退行性疾病生物标志物发现中的应用
N Pavithra,Rukaiah Fatma Begum,S Thanga Ashwini et al.
N Pavithra et al.
Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), and spinocerebellar ataxias (SCAs) are examples of neurodegenerative disorders (NDDs) that share overlapping neuropathological processes and largely a...
Targeting Blood-Brain Barrier Damage with Nanotechnology in the Fight Against Neurodegenerative Diseases [0.03%]
利用纳米技术针对血脑屏障损伤以对抗神经退行性疾病
V Rajeshwar,C Ronald Darwin,K Ilango et al.
V Rajeshwar et al.
The global health burden is attributed to neurodegenerative diseases, of which Alzheimer's disease and Parkinson's disease represent the major NDs. Changes in the blood-brain barrier system are considered an important mechanism in the patho...
Decreased Anti-inflammatory IL-2 and IL-10 and Increased Mononuclear Cell Tissue Factor Correlate with Stroke Severity: Do Anti-inflammatory Cytokines Modulate Thrombosis? [0.03%]
抗炎细胞因子IL-2和IL-10降低以及单核细胞组织因子增高与脑卒中严重程度相关：抗炎细胞因子是否调节血栓形成？
Kiana Mohammadian,Tahereh Kalantari,Rasoul Ebrahimi et al.
Kiana Mohammadian et al.
Introduction: Inflammatory and coagulation pathways are crucial in the pathogenesis and clinical progression of ischemic stroke. The objective of this study was to evaluate serum concentrations of interleukin-2 (IL-2) and...
NEAT1 as a Diagnostic Biomarker and Therapeutic Target for Alzheimer's Disease: A Comprehensive Review [0.03%]
NEAT1作为阿尔茨海默病诊断生物标志物和治疗靶点的全面综述
Mohammad Yasin Zamanian,Olga F Belaia,Zhanna R Gardanova
Mohammad Yasin Zamanian
Alzheimer's disease (AD) is marked by progressive cognitive decline and memory loss. Emerging evidence underscores the role of long non-coding RNAs (lncRNAs), particularly nuclearenriched abundant transcript 1 (NEAT1), in AD pathogenesis. N...
Solid Lipid Nanoparticle Mediated Intranasal Drug Delivery for Brain Targeting: A Comprehensive Review [0.03%]
鼻内给药固脂纳米粒介导的大脑靶向递送：综述文章
Vaishali Kaushal,Abdul Hafeez,Shazia Afzal Usmani et al.
Vaishali Kaushal et al.
The blood-brain barrier (BBB) restricts the passage of drugs into the brain, preventing drug transport to the central nervous system and minimizing the therapeutic effectiveness of several drugs used for brain diseases. The intranasal route...
Biotechnological Perspectives on GSK-3β and Hyperprolactinemia: Implications for the Progression of Alzheimer's Disease [0.03%]
GSK-3β和高催乳素血症的生物技术视角：阿尔茨海默病进展的影响
Sudharshanan Jothi Venkatesan,Meghana Devraj,Mallesh Gowda Virupakshappa et al.
Sudharshanan Jothi Venkatesan et al.
Alzheimer's Disease (AD) is a progressive neurodegenerative condition, which is typified by the extracellular presence of amyloid-B (A2) in the form of plaques, intracellular neurofibrillary tangles, which are made up of hyperphosphorylated...
The Role of the cGAS-STING Pathway in Central Nervous System Diseases [0.03%]
cGAS-STING信号通路在中枢神经系统疾病中的作用
Xiangning He,Xunlu Yin,Qian Chen et al.
Xiangning He et al.
In recent years, the cGAS-STING signaling pathway has emerged as a highly regarded mechanism for intracellular DNA recognition and innate immune activation. This pathway activates downstream interferon and inflammatory factor expression by ...
Targeting Vascular Dementia: Pharmacological Mechanisms and Therapeutic Strategies [0.03%]
血管性痴呆的药理机制及治疗策略研究
Saloni Sharma,Devkant Sharma,Anjali Sharma
Saloni Sharma
Introduction: Vascular dementia is a leading cause of cognitive deterioration worldwide, caused by a complex interplay of pathological mechanisms such as disrupted cerebral blood flow, oxidative stress, neuroinflammation,...