Tirofiban-Nimodipine Combination Therapy for Early Neurological Deterioration in Small Artery Occlusion Stroke: A Retrospective Cohort Study [0.03%]
替罗非班尼莫地平联合治疗小动脉闭塞型卒中早期神经功能恶化的疗效分析：回顾性队列研究
Changhong Tan,Jiali Yang,Qian Yang et al.
Changhong Tan et al.
Introduction: Early neurological deterioration (END) affects approximately 30% of patients with small artery occlusion (SAO) stroke. The combination of tirofiban and nimodipine may simultaneously address microthrombosis a...
Targeted Nanotechnology Approaches to Bypass the Blood-brain Barrier in Neurodegenerative Disorders [0.03%]
靶向纳米技术在神经退行性障碍中绕过血脑屏障的研究进展
Jayasurya Ramesh,B Jayanthi,Vasanth Kumar Mohan et al.
Jayasurya Ramesh et al.
Neurodegenerative diseases like Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic Lateral Sclerosis (ALS), and Huntington's disease (HD) are a growing health burden across the world because of the progressive loss of brain cel...
Future of Preclinical Depression Research: A Perspective of Behavioral Models with Validity and Translational Potential Description [0.03%]
抑郁症前临床研究的未来：具有有效性和转化潜力的行为模型透视
Arzoo Pannu,Uma Agarwal
Arzoo Pannu
Depression is a complicated mental disorder that has a high rate of occurrence all over the world and still ranks as the main reason for the occurrence of both disability and death. Although a lot has been discovered, the neurobiological me...
Rational Design of (Oxadiazol-2-yl) Thiazolidin-4-one Derivatives for Parkinson's Disease: Insights from MD Simulations and Quantum Studies [0.03%]
基于MD模拟和量子化学计算的帕金森病(Oxadiazol-2-基)噻唑烷衍生设计研究
Asif Shaik,Krishna Shevate,Anik Sen et al.
Asif Shaik et al.
Introduction: Parkinson's disease (PD) is a progressive neurodegenerative disorder primarily characterized by the loss of dopaminergic neurons in the substantia nigra. Sirtuin 3 (SIRT3), a mitochondrial NAD⁺-dependent de...
The Gut-Brain Connection: Exploring the Connection Between the Gastrointestinal System and Parkinson's Disease [0.03%]
肠道-大脑连接：探究胃肠道系统与帕金森病之间的联系
Ge YuXuan,Muhammad Khalid Iqbal,Bakhtawar Khan et al.
Ge YuXuan et al.
Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by motor and non-motor symptoms. Recent studies indicate that the gut-brain axis contributes to both the initiation and progression of PD, a disorder that primar...
Tetrandrine Attenuates Cerebral Ischemia/Reperfusion Injury by Regulating Th17/Treg Balance and Mediating PI3K/Akt Pathway in Mice, Based on Network Pharmacology Analysis [0.03%]
基于网络药理学分析的 Tetrandrine通过调节Th17/Treg平衡并介导PI3K/Akt途径来缓解小鼠脑缺血/再灌注损伤
Huanyu Gou,Feng Li,Zishan Huang et al.
Huanyu Gou et al.
Introduction: Stroke has found to be the second leading cause of death in China. Research indicates that the immune imbalance of Th17/Treg is an important pathophysiological alteration and the cause of poor prognosis afte...
Zebrafish (Danio rerio) as a Model for Neurodegenerative Disease Research: Mechanisms, Biomarkers, and Translational Promise [0.03%]
斑马鱼在神经退行性疾病研究中的作用：机制、生物标志物和转化前景
Nikhat Khan,Gaurav Doshi
Nikhat Khan
Zebrafish (Danio rerio) have gained prominence as a versatile vertebrate model for studying neurodegenerative disorders due to their genetic similarity to humans, rapid development, transparency, and suitability for high-throughput drug scr...
Therapeutic Innovations in Parkinson's and Alzheimer's Disease: Molecular Mechanisms and Emerging Strategies [0.03%]
帕金森和阿尔茨海默病的治疗创新：分子机制与新兴策略
S Kasthuri,S Padmavathi,M Jeevitha et al.
S Kasthuri et al.
Parkinson's Disease (PD) and Alzheimer's Disease (AD) are still significant neurodegenerative disorders that have few disease-modifying therapies. In this review, recent advances are assessed based on the strength of evidence for major mole...
Bibliometric Analysis of Neutrophil Extracellular Traps in Stroke: Research Trends and Hotspots [0.03%]
中性粒细胞胞外陷阱在脑卒中领域文献计量分析：研究进展与热点方向
Kexin Zhong,Biao Tang
Kexin Zhong
Stroke is the second leading cause of death in the world, requiring innovation in therapeutic methods. Neutrophil Extracellular Traps (NETs), networks released by neutrophils, are associated with stroke. This study explores the trends and h...
Mendelian Randomization Reveals Potential Drug Targets for Multiple Sclerosis Targeting Ferroptosis [0.03%]
孟德尔随机化揭示了针对多发性硬化症的靶向铁死亡的潜在药物靶点
Tao Wu,Yuze Cao,Lihua Wang et al.
Tao Wu et al.
Introduction: Multiple sclerosis (MS) is a multifactorial autoimmune condition, and existing medications offer limited efficacy, especially regarding the control of disease progression. Our previous research has suggested...